其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Benzopinacol CAS Registry Number: 464-72-2 苯频哪醇

CAS Name: 1,1,2,2-Tetraphenyl-1,2-ethanediol
Additional Names: benzpinacone; tetraphenylethylene glycol
Percent Composition: C 85.22%, H 6.05%, O 8.73%
Literature References: Prepd by photochemical reduction of benzophenone: Bachmann, Org. Synth. coll. vol. II, 71 (1943); L. F. Fieser, Organic Experiments (D. C. Heath Co., Boston, 1964) p 203. By the action of phenylmagnesium bromide on benzil: Acree, Ber. 37, 2761 (1904).

Octafluorocyclobutane CAS Registry Number: 115-25-3 八氟环丁烷

Additional Names: Perfluorocyclobutane
Trademarks: Freon C318 (DuPont)
Percent Composition: C 24.02%, F 75.98%
Literature References: Prepd by pyrolysis of chlorodifluoromethane: Downing et al., US 2384821 (1945 to Kinetic Chem.); US 2551573; US 2615926 (1951; 1952 to du Pont). Thermodynamic studies: Furukawa et al., J. Res. Natl. Bur. Stand. 52, 11 (1954); Duus, Ind. Eng. Chem. 47, 1445 (1955).

Succinimide CAS Registry Number: 123-56-8 丁二酰亚胺

CAS Name: 2,5-Pyrrolidinedione
Additional Names: butanimide; 2,5-diketopyrrolidine; 3,4-dihydropyrrole-2,5-dione; dihydro-3-pyrroline-2,5-dione; 2,5-dioxopyrrolidine
Trademarks: Orotric (SAT...
Literature References: Prepd by rapid distillation of ammonium succinate: Clarke, Behr, Org. Synth. coll. vol. II (1943) p 562; Fehling, Ann. 49, 198 (1844); Bunge, Ann. Suppl. 7, 118 (1870); Menschutkin, Ann. 162, 166 (1872). Prepn by heating succinic acid with ammonia: Fehling, loc. cit.; Franchimont, Friedmann, Rec. Trav. Chim. 25, 79 (1906); with urea: Ma, Sah, C.A. 28, 6108 (1934); see also Tafel, Stern, Ber. 33, 2232 (1900); Koller, Ber. 37, 1598 (1904). Prevention of oxalic lithiasis in rats: J. M. Melon et al., Therapie 26, 991 (1971).

Woodward's Reagent K CAS Registry Number: 4156-16-5 2-乙基-5-苯基异恶唑-3'-磺酸盐

CAS Name: 2-Ethyl-5-(3-sulfophenyl)isoxazolium inner salt
Additional Names: N-ethyl-5-phenylisoxazolium-3'-sulfonate
Percent Composition: C 52.16%, H 4.38%, N 5.53%, O 25.27%, S 12.66%
Literature References: Prepd by reacting 5-phenylisoxazole with chlorosulfonic acid, followed by alkylation with triethyloxonium fluoroborate, and acid hydrolysis: Woodward et al., J. Am. Chem. Soc. 83, 1010 (1961).

Hydroxychloroquine CAS Registry Number: 118-42-3 硫酸羟氯喹

CAS Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol
Additional Names: 7-chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]quinoline; 7-chloro-4-[4-(N-ethyl-N-b-hyd...
Literature References: Prepd by reacting a mixture of 4,7-dichloroquinoline, phenol and N¢-ethyl-N¢-b-hydroxyethyl-1,4-pentadiamine at 125-130°: Surrey, Hammer, J. Am. Chem. Soc. 72, 1814 (1950); Surrey, US 2546658 (1951 to Sterling Drug). Use in combination with cyclophosphamide and azathioprine, q.q.v. in the treatment of rheumatoid arthritis: D. J. McCarty, G. F. Carrera, J. Am. Med. Assoc. 248, 1718 (1982). Reassessment in the treatment of rheumatoid arthritis: Am. J. Med. 75, no. 1A, 1-56 (1983). Series of articles on clinical use: ibid. 85, Suppl. 4A, 1-71 (1988).

Isocrotonic Acid CAS Registry Number: 503-64-0 异巴豆酸

CAS Name: (2Z)-2-Butenoic acid
Additional Names: cis-2-butenoic acid; cis-crotonic acid
Percent Composition: C 55.81%, H 7.02%, O 37.17%
Literature References: Prepd by reacting acetaldehyde with malonic acid in the presence of pyridine: v. Auwers et al., Ann. 432, 46 (1923); from ethyl acetoacetate: Hatch, Nesbitt, J. Am. Chem. Soc. 72, 727 (1950); from but-2-ynoic acid: Allan et al., J. Chem. Soc. 1955, 1862; from CH3CH=CHMgBr + CO2: Normant, Maitte, Bull. Soc. Chim. Fr. 1956, 1439. Structure: v. Auwers, Wissebach, Ber. 56, 715 (1923); Plisov, Bogatskii, Zh. Obshch. Khim. 27, 360 (1957), C.A. 51, 15401c (1957). Review: W. Blau et al., in Ullmann's Encyclopedia of Industrial Chemistry vol. A8 (VCH, Weinheim, 5th ed., 1987) pp 83-89.

Sulfapyrazine CAS Registry Number: 116-44-9 4-氨基-N-(吡嗪-2-基)苯磺酰胺

CAS Name: 4-Amino-N-(pyrazinyl)benzenesulfonamide
Additional Names: N1-2-pyrazinylsulfanilamide; 2-sulfanilamidopyrazine
Percent Composition: C 47.99%, H 4.03%, N 22.39%, O 12.79%, S 12.81%
Literature References: Prepd by reacting acetylsulfanilyl chloride with 2-aminopyrazine in pyridine, followed by hydrolysis and neutralization: Ellingson, US 2420703 (1947). Biological properties: Ghione et al., Chemotherapia 6, 344 (1962).

Sulfathiourea CAS Registry Number: 515-49-1 邻苯二甲酸二异癸酯

CAS Name: 4-Amino-N-(aminothioxomethyl)benzenesulfonamide
Additional Names: 1-sulfanilyl-2-thiourea; sulfathiocarbamideTrademarks: Badional; Fontamide
Percent Composition: C 36.35%, H 3.92%,...
Literature References: Prepd by reacting acetylsulfanilylcyanamide with hydrogen sulfide. Has also been prepd directly from sulfanilyl cyanamide and ammonium sulfide: Leitch et al., Can. J. Res. 23B, 139 (1945); alternate method: Földi et al., US 2332906 (1943).

Aluminum Ethoxide CAS Registry Number: 555-75-9 三乙醇铝

CAS Name: Ethanol aluminum salt
Additional Names: aluminum ethylate
Percent Composition: C 44.44%, H 9.32%, Al 16.64%, O 29.60%
Literature References: Prepd by reacting aluminum powder with absolute ethanol in xylene using small amounts of mercuric chloride and iodine as catalysts: Meerwein, Schmidt, Ann. 444, 232 (1925); Newer Methods of Preparative Organic Chemistry (Interscience, New York, 1948) p 132; see also Farbwerke vorm. Meister, Lucius und Brüning, DE 286596; J. Soc. Chem. Ind. London 34, 1168 (1915); Adkins, J. Am. Chem. Soc. 44, 2178 (1922). Laboratory procedure: Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 333.

Phenyl Biguanide CAS Registry Number: 102-02-3 苯基双胍

CAS Name: N-Phenylimidodicarbonimidic diamide
Additional Names: phenyl diguanide; 1-phenylbiguanide; N-phenyl-N'-guanylguanidine
Percent Composition: C 54.22%, H 6.26%, N 39.52%
Literature References: Prepd by reacting aniline hydrochloride and dicyandiamide in water: Cohn, J. Prakt. Chem. [2] 84, 396; from aniline, dicyandiamide in pyridine contg HCl: Jacobs, Jolles, GB 587907 (1947 to ICI).