其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tetralol CAS Registry Number: 530-91-6 1,2,3,4-四氢萘-2-酚

CAS Name: 1,2,3,4-Tetrahydro-2-naphthalenol
Additional Names: ac-tetrahydro-b-naphthol; ac-b-tetralol
Percent Composition: C 81.04%, H 8.16%, O 10.80%
Literature References: Prepd by hydrogenation of 2-naphthol in the presence of a palladium catalyst: Foreman, Stork, US 2526859 (1950 to Lakeside Labs.); by reduction of 2-naphthol with sodium: Hueckel et al., Ann. 645, 162 (1961). Toxicity study: Draize et al., J. Pharmacol. Exp. Ther. 93, 26 (1948).

Azacyclonol CAS Registry Number: 115-46-8 二苯基(4-哌啶基)甲醇

CAS Name: a,a-Diphenyl-4-piperidinemethanol
Additional Names: a-(4-piperidyl)benzhydrol; diphenyl (g-pyridyl)carbinol; gamma-pipradrolPercent Composition: C 80.86%, H 7.92%, N 5.24%, O 5.98%
Literature References: Prepd by hydrogenation of a,a-diphenyl-4-pyridinemethanol: Schumann et al., US 2804422 (1957 to Merrell).

Tetrahydropyran CAS Registry Number: 142-68-7 四氢吡喃

Additional Names: Pentamethylene oxide
Percent Composition: C 69.72%, H 11.70%, O 18.58%
Literature References: Prepd by hydrogenation of dihydropyran (from furfural): Paul, Bull. Soc. Chim. Fr. [4] 53, 1489 (1933); Andrus, Johnson, Org. Synth. 23, 90 (1943); Cass, Ind. Eng. Chem. 40, 219 (1948).

a -Ergostenol CAS Registry Number: 632-32-6 菜油甾醇

CAS Name: (3b,5a)-Ergost-8(14)-en-3-ol
Percent Composition: C 83.93%, H 12.07%, O 3.99%
Literature References: Prepd by hydrogenation of ergosterol acetate in acetic acid soln: Hart et al., J. Am. Chem. Soc. 52, 2016 (1930); from 22-dihydroergosterol: Windaus, Langer, Ann. 508, 105 (1934).

Nipecotic Acid CAS Registry Number: 498-95-3 3-哌啶甲酸

CAS Name: 3-Piperidinecarboxylic acid
Additional Names: hexahydronicotinic acid
Percent Composition: C 55.79%, H 8.58%, N 10.84%, O 24.77%
Literature References: Prepd by hydrogenation of nicotinic acid with platinum oxide catalyst: McElvain, Adams, J. Am. Chem. Soc. 45, 2738 (1923); with rhodium on alumina catalyst: Freifelder, J. Org. Chem. 28, 1135 (1963); idem, US 3159639 (1964 to Abbott).

a -Phenylglycine CAS Registry Number: 69-91-0 Alpha-氨基苯乙酸

CAS Name: a-Aminobenzeneacetic acid
Additional Names: a-aminophenylacetic acid; a-amino-a-toluic acid; C-phenylglycine
Percent Composition: C 63.57%, H 6.00%, N 9.27%, O 21.17%
Literature References: Prepd by hydrolysis of a-aminophenylacetonitrile with dil hydrochloric acid: Marvel, Noyes, J. Am. Chem. Soc. 42, 2264 (1920); R. E. Steiger, Org. Synth. coll. vol. III, 84 (1955).

Tetradecamethylhexasiloxane CAS Registry Number: 107-52-8 十四甲基六硅氧烷

Percent Composition: C 36.63%, H 9.22%, O 17.43%, Si 36.71%
Literature References: Prepd by hydrolysis of dimethyldichlorosilane and trimethylchlorosilane: Patnode, Wilcock, J. Am. Chem. Soc. 68, 358 (1946); by reaction of hexamethyldisiloxane with octamethylcyclotetrasiloxane and sulfuric acid: eidem, ibid. 362; Patnode, US 2469888 (1949 to General Electric); by cohydrolysis of ethoxytrimethylsilane and diethoxydimethylsilane: Hunter et al., J. Am. Chem. Soc. 68, 2284 (1946); Hyde, US 2457677 (1948 to Corning Glass).

p-Nitrophenylacetic Acid CAS Registry Number: 104-03-0 对硝基苯乙酸

CAS Name: 4-Nitrobenzeneacetic acid
Additional Names: p-nitro-a-toluic acid
Percent Composition: C 53.04%, H 3.89%, N 7.73%, O 35.33%
Literature References: Prepd by hydrolysis of p-nitrobenzyl cyanide with 50% H2SO4: Robertson, Org. Synth. 2, 59 (1922); coll. vol. I, 406 (2nd ed., 1941).

Methestrol CAS Registry Number: 130-73-4 4-[4-(4-羟基-3-甲基苯基)己烷-3-基]-2-甲基苯酚

CAS Name: 4,4'-(1,2-Diethyl-1,2-ethanediyl)bis[2-methylphenol]
Additional Names: 4,4'-(1,2-diethylethylene)di-o-cresol; 3,4-bis(3-methyl-4-hydroxyphenyl)hexane; dimethylhexestrol; promethestrol...
Literature References: Prepd by hydrolysis of the dipropionate: Niederl et al., J. Am. Chem. Soc. 70, 508 (1948). Chromatographic identification and determn: R. W. Roos, J. Pharm. Sci. 63, 594 (1974). Pharmacologic study: P. H. Jellinck, A. M. Newcombe, Biochem. Pharmacol. 29, 3031 (1980). Pharmacotherapeutic study: C. B. Hammond, W. S. Maxson, Fertil. Steril. 37, 5 (1982).

Cyclobutyrol CAS Registry Number: 512-16-3 环丁酸醇

CAS Name: a-Ethyl-1-hydroxycyclohexaneacetic acid
Additional Names: 1-cyclohexanol-a-butyric acid; a-(1-hydroxycyclohexyl)butyric acid; 1-hydroxy-a-ethylcyclohexylacetic acid
Percent Composi...
Literature References: Prepd by hydrolysis of the ethyl ester obtained by the Reformatski reaction: Kon, Naravanan, J. Chem. Soc. 1927, 1536; Kandiah, Linstead, ibid. 1929, 2150; J. G. Maillard et al., Bull. Soc. Chim. Fr. 1958, 244; eidem, DE 1094254; eidem, US 3065134 (1959, 1962 to Lab. Jacques Logeais). Activity studies: Roquet, Jousse, Arch. Int. Pharmacodyn. 125, 172 (1960).