其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Dicyanodiamidine Sulfate CAS Registry Number: 591-01-5 胍基脲硫酸盐

CAS Name: (Aminoiminomethyl)urea sulfate (2:1)
Additional Names: biuretamidine sulfate; carbamylguanidine sulfate; guanylurea sulfate
Percent Composition: C 15.89%, H 4.67%, N 37.07%, O 31.7...
Literature References: Prepd by heating dicyanodiamide with H2SO4 and H2O.

Michler's Base CAS Registry Number: 101-61-1 4,4'-四甲基二氨基二苯甲烷

CAS Name: 4,4'-Methylenebis(N,N-dimethylbenzenamine)
Additional Names: 4,4'-methylenebis(N,N-dimethylaniline); bis(p-dimethylaminophenyl)methane; 4,4'-tetramethyldiaminodiphenylmethane; tetra-b...
Literature References: Prepd by heating dimethylaniline with 40% formaldehyde and concd HCl: Mekel, DE 1026322 (1958 to BASF); Hey, Sanderson, J. Chem. Soc. 1960, 3203; from dimethylaniline + diacetylperoxide: Horner et al., Ann. 626, 1 (1959); from dimethylaniline + tert-butylperbenzoate: Sosnovsky, Yang, J. Org. Chem. 25, 899 (1960).

Phenarsazine Chloride CAS Registry Number: 578-94-9 二苯胺氯胂

CAS Name: 10-Chloro-5,10-dihydrophenarsazine
Additional Names: 5-aza-10-arsenaanthracene chloride; 10-chloro-5,10-dihydroarsacridine; diphenylaminechlorarsine; phenazarsine chloride; adamsite; ...
Literature References: Prepd by heating diphenylamine with arsenic trichloride: DE 281049 (1914 to I. G. Farben.); Wieland, Reinheimer, Ann. 423, 12 (1921); Lewis, Hamilton, J. Am. Chem. Soc. 43, 2222 (1921); Burton, Gibson, J. Chem. Soc. 1926, 450.

Methyldiphenylamine CAS Registry Number: 552-82-9 N-甲基二苯胺

CAS Name: N-Methyl-N-phenylbenzenamine
Additional Names: diphenylmethylamine
Percent Composition: C 85.21%, H 7.15%, N 7.64%
Literature References: Prepd by heating diphenylamine, methyl alcohol and HCl.

R-11 CAS Registry Number: 126-15-8 二环丁并四氢糠醛

CAS Name: 1,5a,6,9,9a,9b-Hexahydro-4a(4H)-dibenzofurancarboxaldehyde
Additional Names: 2,3,4,5-bis(2-butenylene)tetrahydrofurfuralTrademarks: MGK Repellent 11 (McLaughlin)
Percent Compositio...
Literature References: Prepd by heating furfuraldehyde with butadiene and water under pressure: Hillyer, Nicewander, US 2683151 (1954 to Phillips Petroleum). Clinical efficacy vs sand flies: F. P. Fossati, M. Maroli, Trans. R. Soc. Trop. Med. Hyg. 80, 771 (1986).

Thiocarbarsone CAS Registry Number: 120-02-5 2,2'-[[[4-[(氨基羰基)氨基]苯基]砷]二(硫)]二乙酸

CAS Name: 2,2'-[[[4-[(Aminocarbonyl)amino]phenyl]arsinidene]bis(thio)]bis[acetic acid]
Additional Names: (p-ureidophenylarsylenedithio)diacetic acid; 4-carbamidophenyl bis[carboxymethylthio]ars...
Literature References: Prepd by heating HSCH2COOH and Carbarsone oxide in aq alkali, purified by repeated precipitation with acid and dissolving in alkali: Rohrmann, US 2516831 (1950 to Lilly). Compare Arsenamide.

Glyconiazide CAS Registry Number: 3691-74-5 N'-((S,E)-2-((2R,3R,4S)-3,4-二羟基-5-氧代四氢呋喃-2-基)-2-羟基亚乙基)异烟酰肼

CAS Name: D-Glucuronic acid g-lactone 1-[(4-pyridinylcarboxyl)hydrazone]
Additional Names: D-glucuronolactone isonicotinoylhydrazone; isonicotinoylhydrazone of D-glucuronic acid lactone; isonic...
Literature References: Prepd by heating isonicotinic acid hydrazide with D-glucuronolactone in methanol: Sah, J. Am. Chem. Soc. 75, 2512 (1953); Sah, US 2940899 (1960 to U. of Calif.).

Lactic Acid Lactate CAS Registry Number: 617-57-2 2-羟基丙酸-1-羰乙酯

CAS Name: 2-Hydroxypropanoic acid 1-carboxyethyl ester
Additional Names: 2-(lactoyloxy)propanoic acid; 2-(2-hydroxypropanoyloxy)propanoic acid
Percent Composition: C 44.45%, H 6.22%, O 49.34...
Literature References: Prepd by heating lactic acid at 120° for 10 hours: Dietzel, Krug, Ber. 58, 1307 (1925).

Allocupreide Sodium CAS Registry Number: 5965-40-2 苯甲酸,3-[[(2-丙烯-1-乙氨基)噻氧甲基]氨基,铜(1+)钠盐(1:1:1)

CAS Name: 3-[[(2-Propenylamino)thioxomethyl]amino]benzoic acid monocopper (1+) monosodium salt
Additional Names: m-[(N-allyl-1-mercaptoformimidoyl)amino]benzoic acid copper derivative sodium sa...
Literature References: Prepd by heating m-aminobenzoic acid with allyl isothiocyanate and treating the resulting m,w-allylthioureidobenzoic acid with cuprous chloride: Bockmühl, Fritzsche, DE 551421 (1932 to I. G. Farben).

Pyromellitic Acid CAS Registry Number: 89-05-4 均苯四甲酸

CAS Name: 1,2,4,5-Benzenetetracarboxylic acid
Percent Composition: C 47.26%, H 2.38%, O 50.36%
Literature References: Prepd by heating mellitic (benzenehexacarboxylic) acid with KHSO4 and H2SO4: Silberrad, J. Chem. Soc. 89, 1795 (1906) (actually the dianhydride, mp 286°, is obtained by this method). Laboratory prepn from pine or spruce charcoal: Philippi, Thelen, Org. Synth. coll. vol. II, 551 (1943); by oxidation of benzene derivatives contg substituents in the 1,2,4,5 positions: Jacobsen, Ber. 17, 2516 (1884).