其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

p-Dimethylaminobenzaldehyde CAS Registry Number: 100-10-7 对二甲氨基苯甲醛

Additional Names: 4-Dimethylaminobenzenecarbonal; Ehrlich's reagent
Percent Composition: C 72.46%, H 7.43%, N 9.39%, O 10.72%
Literature References: Prepd by formylation of dimethylaniline with dimethylformamide: Campaigne, Archer, Org. Synth. coll. vol. IV, 331 (1963).

N 2 -Formylsulfisomidine CAS Registry Number: 795-13-1

CAS Name: N-(2,6-Dimethyl-4-pyrimidinyl)-4-(formylamino)benzenesulfonamide
Additional Names: 4'-[(2,6-dimethyl-4-pyrimidinyl)sulfamoyl]formanilide; N-[4-[[(2,6-dimethyl-4-pyrimidinyl)amino]sulf...
Literature References: Prepd by formylation of sulfisomidine: Brand, Rieckhoff, DE 1122511; DE 1126857 (both 1962 to VEB Farbenfabrik Wolfen).

Potassium Biphthalate CAS Registry Number: 877-24-7 邻苯二甲酸氢钾

CAS Name: Phthalic acid potassium acid salt
Additional Names: potassium acid phthalate; potassium hydrogen phthalate; acid potassium phthalate
Percent Composition: C 47.05%, H 2.47%, K 19.15...
Literature References: Prepd by half-neutralization of a phthalic anhydride soln: F. J. Welcher, Organic Analytical Reagents vol. 2 (Van Nostrand, New York, 1947) pp 75-79.

Methyl Lactate CAS Registry Number: 547-64-8 乳酸甲酯

CAS Name: 2-Hydroxypropanoic acid methyl ester
Percent Composition: C 46.15%, H 7.75%, O 46.11%
Literature References: Prepd by heating 1 mole lactic acid condensation polymer with 2.5-5 moles of methanol and a small quantity of H2SO4 at 100° for 1-4 hours in a heavy-walled bottle: Rehberg, Org. Synth. coll. vol. III, 47-48 (1955).

Anthrimide CAS Registry Number: 82-22-4 1,1'-亚氨基二蒽醌

CAS Name: 1,1'-Iminobis-9,10-anthracenedione
Additional Names: 1,1'-iminodianthraquinone; dianthraquinonylamine; dianthrimide
Percent Composition: C 78.31%, H 3.52%, N 3.26%, O 14.90%
Literature References: Prepd by heating 1-aminoanthraquinone with 1-chloroanthraquinone in nitrobenzene in the presence of copper: Bayer Co., DE 162823; Chem. Zentralbl. 1905, II, 1206; Eckert, Steiner, Monatsh. Chem. 35, 1129 (1914); FIAT Report no. 1313, vol. II (1948), p 137.

Narcobarbital CAS Registry Number: 125-55-3 那可比妥

CAS Name: 5-(2-Bromo-2-propenyl)-1-methyl-5-(1-methylethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-(2-bromoallyl)-5-isopropyl-1-methylbarbituric acid; N-methyl-b-bromoallylisoprop...
Literature References: Prepd by heating 5-isopropyl-1-methylbarbituric acid with 2,3-dibromo-1-propene in alkaline soln: Boedecker, Gruber, DE 613403 (1937 to Riedel de Haen). See also DE 627380; US 2080071.

Methapyrilene CAS Registry Number: 91-80-5 美沙吡林

CAS Name: N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine
Additional Names: 2-[(2-dimethylaminoethyl)-2-thenylamino]pyridine; N,N-dimethyl-N'-(2-pyridyl)-N'-(2-thenyl)ethylen...
Literature References: Prepd by heating a 2-thenyl halide with an alkali metal salt of N,N-dimethyl-N¢-(2-pyridyl)ethylenediamine: Kyrides, US 2581868 (1952 to Monsanto). Alternate syntheses: Weston, J. Am. Chem. Soc. 69, 980 (1947); Clapp et al., ibid. 1549. Toxicity data: H. M. Lee et al., Proc. Soc. Exp. Biol. Med. 80, 458 (1952). Carcinogenicity study: W. Lijinsky et al., Science 209, 817 (1980). Study of mechanism of hepatocarcinogenicity: K. L. Steinmetz et al., Carcinogenesis 9, 959 (1988). Clinical pharmacokinetics: E. P. Calandre et al., Clin. Pharmacol. Ther. 29, 527 (1981). HPLC determn in feed and sleep aid tablets: B. Shaikh, M. R. Hallmark, J. Assoc. Off. Anal. Chem. 64, 889 (1981); in feed, urine and wastewater: H. C. Thompson, Jr., C. L. Holder, J. Chromatogr. 283, 251 (1984).

m-Nitrocinnamic Acid CAS Registry Number: 555-68-0 间硝基肉桂酸

CAS Name: 3-(3-Nitrophenyl)-2-propenoic acid
Percent Composition: C 55.96%, H 3.65%, N 7.25%, O 33.13%
Literature References: Prepd by heating a mixture of m-nitrobenzaldehyde, sodium acetate and acetic anhydride: Thayer, Org. Synth. 5, 83 (1925). From m-nitrobenzaldehyde and malonic acid in the presence of glycine in a little water at 100°: Dakin, J. Biol. Chem. 7, 54 (1909-1910).

Benzanthrone CAS Registry Number: 82-05-3 苯并蒽酮

CAS Name: 7H-Benz[de]anthracen-7-one
Percent Composition: C 88.67%, H 4.38%, O 6.95%
Literature References: Prepd by heating a reduction product of anthraquinone with sulfuric acid and glycerol: Macleod, Allen, Org. Synth. 14, 4 (1934); cf. US 1626392 (1927). Review of toxicology: G. B. Singh et al., J. Sci. Ind. Res. 49, 288-296 (1990).

Tryparsamide CAS Registry Number: 554-72-3 锥虫胂胺

CAS Name: [4-[(2-Amino-2-oxoethyl)amino]phenyl]arsonic acid monosodium salt
Additional Names: N-(carbamoylmethyl)arsanilic acid monosodium salt; monosodium N-phenylglycinamide-p-arsonate
Tra...
Literature References: Prepd by heating a soln of arsanilic acid in aq NaOH, Na2CO3 and chloroacetamide: Jacobs, Heidelberger, J. Am. Chem. Soc. 41, 1590 (1919); Org. Synth. 8, 100 (1928). US 1280119; US 1280124; US 1280126 (1918); US 2465308 (1949).