其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

N-Ethylmaleimide CAS Registry Number: 128-53-0 N-乙基顺丁烯二酰亚胺

CAS Name: 1-Ethyl-1H-pyrrole-2,5-dione
Percent Composition: C 57.59%, H 5.64%, N 11.19%, O 25.57%
Literature References: Prepd by heating N-ethylmaleamic acid in paraffin: Marrian, J. Chem. Soc. 1949, 1515.

Thiosalicylic Acid CAS Registry Number: 147-93-3 硫代水杨酸

CAS Name: 2-Mercaptobenzoic acid
Additional Names: o-sulfhydrylbenzoic acid
Percent Composition: C 54.53%, H 3.92%, O 20.75%, S 20.80%
Literature References: Prepd by heating o-halogenated benzoic acids with an alkaline hydrosulfide in the presence of copper: DE 189200 (1906); by reduction of dithiosalicylic acid: Claasz, Ber. 45, 2427 (1912); DE 205450; C. F. H. Allen, D. D. MacKay, Org. Synth. coll. vol. II, 580 (1943).

Thiocarbamizine CAS Registry Number: 91-71-4 硫卡巴胂

CAS Name: 2,2'-[[[4-[(Aminocarbonyl)amino]phenyl]arsinidene]bis(thio)]bis[benzoic acid]
Additional Names: (p-ureidophenylarsylenedithio)di-o-benzoic acid; (p-ureidobenzenearsylenedithio)di-o-be...
Literature References: Prepd by heating o-HSC6H4COOH and Carbarsone oxide in aq alkali, purified by repeated precipitation with acid and dissolving in alkali: Rohrmann, US 2516831 (1950 to Lilly). Compare Arsenamide, Thiocarbarsone, Carbarsone.

Benzylimidobis(p-methoxyphenyl)methane CAS Registry Number: 524-96-9 N-[双(4-甲氧基苯基)亚甲基]苄胺

CAS Name: N-[Bis(4-methoxyphenyl)methylene]benzenemethanamine
Percent Composition: C 79.73%, H 6.39%, N 4.23%, O 9.66%
Literature References: Prepd by heating p,p¢-dimethoxybenzophenone, thionyl chloride and benzylamine: Schönberg, Urban, Ber. 67, 1999 (1934).

p-tert-Butylphenol CAS Registry Number: 98-54-4 对叔丁基苯酚

CAS Name: 4-(1,1-Dimethylethyl)phenol
Additional Names: butylphen
Percent Composition: C 79.95%, H 9.39%, O 10.65%
Literature References: Prepd by heating phenol with isobutanol in the presence of zinc chloride: DE 17311; Frdl. 1, 22; also from phenol, tert-butyl chloride and excess alkali in alcohol: Lewis, J. Chem. Soc. 83, 329 (1903). See also Smith, J. Am. Chem. Soc. 55, 3718 (1933); Natelson, ibid. 56, 1583 (1934); Huston, Hsieh, ibid. 58, 439 (1936); US 2039344 (1936 to Dow); Isagulyants, Bagryantseva, C.A. 33, 8183 (1939). Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969).

p-Bromophenyl Isocyanate CAS Registry Number: 2493-02-9 4-溴苯异氰酸酯

CAS Name: 1-Bromo-4-isocyanatobenzene
Additional Names: 4-bromophenylcarbimide; p-bromophenylcarbonimide; p-bromocarbanil
Percent Composition: C 42.46%, H 2.04%, Br 40.35%, N 7.07%, O 8.08%
Literature References: Prepd by heating phenyl isocyanate dibromide: Curtius, J. Prakt. Chem. 87, 517 (1913); by distilling p-bromophenylurethan and P2O5: Dennstedt, Ber. 13, 228 (1880).

Sulfanilyl Fluoride CAS Registry Number: 98-62-4 4-氨基苯磺酰氟

CAS Name: p-Aminobenzenesulfonyl fluoride
Percent Composition: C 41.14%, H 3.45%, F 10.85%, N 8.00%, O 18.27%, S 18.30%
Literature References: Prepd by heating potassium fluoride with 4-acetamidobenzenesulfonyl chloride: Parker, Hofmann, US 2576037 (1951 to Am. Cyanamid).

Morphothebaine CAS Registry Number: 478-53-5 10-甲氧基-6-甲基-5,6,6A,7-四氢-4H-二苯并[去,G]喹啉-2,11-二醇

CAS Name: 5,6,6a,7-Tetrahydro-10-methoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,11-diol
Additional Names: 10-methoxyaporphine-2,11-diol; 2,11-dihydroxy-10-methoxyaporphine
Percent Composition:...
Literature References: Prepd by heating thebaine with HCl. Formation from bulbocapnine: Ayer, Taylor, J. Chem. Soc. 1956, 472. Review: Small, Lutz, "Chemistry of the Opium Alkaloids" in U.S. Public Health Reports Suppl. No. 103 (Washington, 1932); R. H. F. Manske, H. L. Holmes, The Alkaloids vol. II (Academic Press, New York, 1952) pp 112-116.

Carbromal CAS Registry Number: 77-65-6 乙溴酰脲

CAS Name: N-(Aminocarbonyl)-2-bromo-2-ethylbutanamide
Additional Names: (a-bromo-a-ethylbutyryl)urea; (a-bromo-a-ethylbutyryl)carbamide; bromodiethylacetylurea; bromodiethylacetylcarbamide
T...
Literature References: Prepd by heating urea (to ~50°) with a-bromo-a-ethylbutyryl bromide (C2H5)2CBrCOBr, see DE 225710 (1910); Frdl. 10, 1160; Chem. Zentralbl. 1910, II, 1008. Patent literature: Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931); H. P. Kaufmann, Arzneimittel-Synthese (Berlin, 1953).

Triglyme CAS Registry Number: 112-49-2 三乙二醇二甲醚

CAS Name: 2,5,8,11-Tetraoxadodecane
Additional Names: triethylene glycol dimethyl ether
Percent Composition: C 53.91%, H 10.18%, O 35.91%
Literature References: Prepd by high pressure hydrogenation of 1,1,2,2-tetrakis(2-methoxyethoxy)ethane: McNamee, MacDowell, US 2425042 (1947 to Carbide Carbon Chem.).