其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

MOPS CAS Registry Number: 1132-61-2 3-(N-吗啉)丙磺酸

CAS Name: 4-Morpholinepropanesulfonic acid
Additional Names: 3-(N-morpholino)propanesulfonic acid; N-(3-sulfopropyl)morpholine
Percent Composition: C 40.18%, H 7.23%, N 6.69%, O 30.58%, S 15...
Literature References: One of the zwitterionic amino acids known as "Good" buffers; active in the pH range of 6.5-8.0. Prepn: C. F. H. Allen et al., Anal. Chem. 37, 156 (1965); N. E. Good, S. Izawa, "Hydrogen Ion Buffers," in Methods Enzymol. 24, 53-65 (1972). Temperature effects on pK: M. Sankar, R. G. Bates, Anal. Chem. 50, 1922 (1978); and pH: R. N. Roy et al., Cryo-Lett. 6, 139 (1985). Effects on "Lowry" protein determn: H. M. Himmel, W. Heller, J. Clin. Chem. Clin. Biochem. 25, 909 (1987). Uses as a biological buffer: E. P. Paques et al., Eur. J. Biochem. 107, 447 (1980); L. A. Sonna et al., J. Biol. Chem. 263, 6625 (1988).

CAPS CAS Registry Number: 1135-40-6 3-(环己胺)-1-丙磺酸

CAS Name: 3-(Cyclohexylamino)-1-propanesulfonic acid
Percent Composition: C 48.84%, H 8.65%, N 6.33%, O 21.69%, S 14.49%
Literature References: One of the zwitterionic amino acids known as "Good" buffers; active in the pH range of 9.7-11.1. Prepn: H. Dorn, K. Walter, Z. Chem. 7, 151 (1967). Thermodynamic parameters: C. D. McGlothlin, J. Jordan, Anal. Lett. 9, 245 (1976). Effects on protein measurement: V. Kaushal, L. D. Barnes, Anal. Biochem. 157, 291 (1986); H. M. Himmel, W. Heller, J. Clin. Chem. Clin. Biochem. 25, 909 (1987). Use as buffer: I. I. Koukli et al., Analyst 113, 603 (1988); R. M. Smith et al., J. Chromatogr. 514, 97 (1990).

PIPES CAS Registry Number: 5625-37-6 哌嗪-1,4-二乙磺酸

CAS Name: 1,4-Piperazinediethanesulfonic acid
Additional Names: piperazine-N,N'-bis(2-ethanesulfonic acid); 1,4-piperazinebis(ethanesulfonic acid)
Percent Composition: C 31.78%, H 6.00%, N 9...
Literature References: One of the zwitterionic N-substituted aminosulfonic acids known as "Good" buffers; active in the pH range 6-8.5. Prepn: N. Good et al., Biochemistry 5, 467 (1966). Interference with Lowry protein determn: H. M. Himmel, W. Heller, J. Clin. Chem. Clin. Biochem. 25, 909 (1987). Use as biological buffer: R. Salema, I. Brandao, J. Submicrosc. Cytol. 5, 79 (1973); S. Haviernick et al., J. Microsc. 135, 83 (1984).

MES CAS Registry Number: 4432-31-9 吗啉乙磺酸

CAS Name: 4-Morpholineethanesulfonic acid
Additional Names: 2-(4-morpholino)ethyl sulfonate; 2-(N-morpholino)ethanesulfonic acid
Percent Composition: C 36.91%, H 6.71%, N 7.17%, O 32.78%, S ...
Literature References: One of the zwitterionic N-substituted aminosulfonic acids known as Good Buffers, active in the pH range 6-8. Prepn as sodium salt: S. Malkiel, J. P. Mason, J. Org. Chem. 8, 199 (1943); as acid: N. E. Good et al., Biochemistry 5, 467 (1966). Thermodynamic parameters: C. D. McGlothlin, J. Jordan, Anal. Lett. 9, 245 (1976). Acid-base properties: A. Balikungeri, Chimia 43, 13 (1989). Interference with protein determn: P. L. Lleu, G. Rebel, Anal. Biochem. 192, 215 (1991). Use as buffer: S. C. Lee et al., J. AOAC Int. 75, 395 (1992); P. J. Henney et al., Anim. Genet. 25, 363 (1994).

Homatropine CAS Registry Number: 87-00-3 后马托品

CAS Name: endo-(±)-a-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Additional Names: 1aH,5aH-tropan-3a-ol mandelate; mandelyltropeine; tropine mandelate
Percent C...
Literature References: Ophthalmic anticholinergic. Prepd from mandelic acid and tropine: Ladenburg, Ann. 217, 82 (1883); Chemnitius, J. Prakt. Chem. 117, 142 (1927). Prepn of D(-)- and L(+)-forms: Werner, Miltenberger, Ann. 631, 163 (1960). Comprehensive description: F. J. Muhtadi et al., Anal. Profiles Drug Subs. 16, 245-290 (1987). Toxicity: R. L. Cahen, K. Tvede, J. Pharmacol. Exp. Ther. 105, 166 (1952).

Tropicamide CAS Registry Number: 1508-75-4 托吡卡胺

CAS Name: N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
Additional Names: N-ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; N-ethyl-N-(g-picolyl)tropamide
Trademarks: Myd...
Literature References: Ophthalmic anticholinergic. Prepn: Rey-Bellet, Spiegelberg, US 2726245 (1955 to Hoffmann-La Roche). Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 565-580 (1974).

Cyclopentolate CAS Registry Number: 512-15-2 环喷托酯

CAS Name: a-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester
Additional Names: 1-hydroxy-a-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester; 2-dimethylaminoethyl ...
Literature References: Ophthalmic anticholinergic. Prepn: Treves, US 2554511 (1951 to Schieffelin).

Loteprednol Etabonate CAS Registry Number: 82034-46-6 依碳氯替泼诺

CAS Name: (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester
Additional Names: chloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,...
Literature References: Ophthalmic corticosteroid. Prepn: N. S. Bodor, BE 889563 (1981 to Otsuka); idem, US 4996335 (1991). Physicochemical properties: M. Alberth et al., J. Biopharm. Sci. 2, 115 (1991). HPLC determn in plasma and urine: G. Hochhaus et al., J. Pharm. Sci. 81, 1210 (1992). NMR structural studies: S. Rachwal et al., Steroids 61, 524 (1996); idem et al., ibid. 63, 193 (1998). Metabolism and transdermal permeability: N. Bodor et al., Pharm. Res. 9, 1275 (1992). Evaluation of effect on intraocular pressure: J. D. Bartlett et al., J. Ocul. Pharmacol. 9, 157 (1993). Clinical trial in keratoconjunctivitis sicca: S. C. Pflugfelder et al., Am. J. Ophthalmol. 138, 444 (2004). Review of ophthalmic clinical studies: J. F. Howes, Pharmazie 55, 178-183 (2000).

Trimebutine CAS Registry Number: 39133-31-8 曲美布汀

CAS Name: 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester
Percent Composition: C 68.20%, H 7.54%, N 3.61%, O 20.65%
Literature References: Opioid receptor agonist. Prepn by esterification: C. P. J. Roux, D. R. Torossian, FR 1344455 (1963 to Jouveinal), C.A. 60, 15777g (1964); see also: D. R. Torossian, G. G. Aubard, GB 1342547 (1974 to Jouveinal). HPLC determn in plasma: M. Lavit et al., Arzneim.-Forsch. 50, 640 (2000). Review of pharmacology and clinical experience: M. Delvaux, D. Wingate, J. Int. Med. Res. 25, 225-246 (1997).

Iopronic Acid CAS Registry Number: 41473-08-9

CAS Name: 2-[[2-[3-(Acetylamino)-2,4,6-triiodophenoxy]ethoxy]methyl]butanoic acid
Additional Names: (±)-2-[[2-(3-acetamido-2,4,6-triiodophenoxy)ethoxy]methyl]butyric acid; 3-[2-(3-acetylam...
Literature References: Oral cholecystographic agent. Prepn: E. Felder, D. Pitre, DE 2128902; eidem, US 3842124 (1972, 1974 both to Bracco); E. Felder et al., Farmaco Ed. Sci. 31, 349 (1976). Pharmacology, toxicology: P. Tirone, G. Rosati, Farmaco Ed. Prat. 31, 397, 437 (1976). Series of articles on metabolism: ibid. 516-546; 755. Intestinal absorption: J. R. Amberg et al., Invest. Radiol. 15, S136 (1980). Effect on bile flow and composition: J. L. Barnhart et al., ibid. S124. Toxicity: P. Tirone, G. Rosati, Farmaco Ed. Prat. 31, 397 (1976).