其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Alizarin CAS Registry Number: 72-48-0 1,2-二羟基蒽醌,茜素

CAS Name: 1,2-Dihydroxy-9,10-anthracenedione
Additional Names: 1,2-dihydroxyanthraquinone; C.I. Mordant Red 11; C.I. Pigment Red 83; C.I. 58000
Percent Composition: C 70.00%, H 3.36%, O 26.6...
Literature References: Occurs in the root of the madder plant (Rubia tinctorum L., Rubiaceae; Krappwurzel) in combination with 2 mols glucose, called ruberythric acid. Was known and used in ancient Egypt, Persia, and India. Synthesized from 2-anthraquinonesulfonic acid sodium salt : Caro et al., Ber. 3, 359 (1870); Perkin, Ber. 9, 281 (1876). Historical review: Fieser, J. Chem. Educ. 7, 2609 (1930). Laboratory prepn: Gattermann-Wieland, Laboratory Methods of Organic Chemistry (New York, 1937). Modern methods of manufacture: Pohl, Ullmanns Encyklopädie der technischen Chemie vol. I, p 200; Fierz-David and Blangey, Grundlegende Operationen der Farbenchemie (Vienna, 5th ed., 1943). See also Colour Index vol. 4, (3rd ed., 1971) p 4513.

Limonene CAS Registry Number: 138-86-3 柠檬烯;双戊烯

CAS Name: 1-Methyl-4-(1-methylethenyl)cyclohexene
Additional Names: p-mentha-1,8-diene; cinene; cajeputene; kautschin
Percent Composition: C 88.16%, H 11.84%
Literature References: Occurs in various ethereal oils, particularly in oils of lemon, orange, caraway, dill and bergamot. Isoln of d-limonene from mandarin peel oil (Citrus reticulata Blanco, Rutaceae): Kugler, Kováts, Helv. Chim. Acta 46, 1480 (1963). Review: J. L. Simonsen, The Terpenes vol. I (University Press, Cambridge, 2nd ed., 1947) pp 143-165.

Isoeugenol CAS Registry Number: 97-54-1 异丁香酚(正+反)

CAS Name: 2-Methoxy-4-(1-propenyl)phenol
Additional Names: 4-hydroxy-3-methoxy-1-propenylbenzene; 4-propenylguaiacol
Percent Composition: C 73.15%, H 7.37%, O 19.49%
Literature References: Occurs in ylang-ylang and other essential oils. Prepd from eugenol: West, J. Soc. Chem. Ind. 59, 275 (1940); Pal'gi, Zh. Obshch. Khim. 28, 2239 (1958). Stereochemistry: von Auwers, Ber. 68, 1346 (1935); Puxeddu, Rattu, Gazz. Chim. Ital. 67, 647 (1937). Toxicity study: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).

a -Amyrin CAS Registry Number: 638-95-9 α-香树脂醇

CAS Name: (3b)-Urs-12-en-3-ol
Additional Names: a-amyrenol; viminalol
Percent Composition: C 84.44%, H 11.81%, O 3.75%
Literature References: Occurs mostly as acetate in latex of rubber trees, in latex from Ficus variegata Blume, Moraceae, also in Balanophora elongata Blume, Balanophoraceae, and in Erythroxylum coca Lam. var. novogranatense Morris, and var. spruceanum Burck, Erythroxylaceae. Isoln from Manila elemi: Vesterberg, Westerlind, Ann. 428, 247 (1922). Structural studies: Spring, Vickerstaff, J. Chem. Soc. 1937, 249; Beynon et al., ibid. 1938, 1233; Meisels et al., Helv. Chim. Acta 32, 1075 (1949), 38, 1298 (1955); Melera et al., ibid. 39, 441 (1956). Identity with viminalol: Soldin, Marais, J. Pharm. Soc. 55, 452 (1966). Formation from ursolic acid: Goodson, J. Chem. Soc. 1938, 999; from boswellic acid: Ruzicka, Wirz, Helv. Chim. Acta 22, 948 (1939). Partial synthesis from glycyrrhetic acid and stereochemistry: Corey, Cantrall, J. Am. Chem. Soc. 81, 1745 (1959). Review: J. Simonsen, W. C. J. Ross, The Terpenes vol. IV (University Press, Cambridge, 1957) pp 116-148.

Zygadenine CAS Registry Number: 545-45-9 棋盘花碱

CAS Name: 4a,9-Epoxycevane-3b,4,14,15a,16b,20-hexol
Percent Composition: C 65.69%, H 8.78%, N 2.84%, O 22.69%
Literature References: Occurs together with germine in various species of Zygadenus (death camas) and Veratrum (Liliaceae): Heyl et al., J. Am. Chem. Soc. 35, 258 (1913); Heyl, Herr, ibid. 71, 1751 (1949); Kupchan, Deliwala, ibid. 75, 1025 (1953); Klohs et al., ibid. 4925; Stoll, Seebeck, Helv. Chim. Acta 36, 1570 (1953); Kupchan et al., J. Am. Chem. Soc. 77, 689, 755 (1955). Structure: Kupchan, ibid. 78, 3546 (1956); 81, 1925 (1959).

Fulvoplumierin CAS Registry Number: 20867-01-0 褐鸡蛋花素

CAS Name: (7E)-7-(2E)-Butenylidene-1,7-dihydro-1-oxocyclopenta[c]pyran-4-carboxylic acid methyl ester
Additional Names: 3-(2-butenylidene)-2-carboxy-a-(hydroxymethylene)-1,4-cyclopentadiene-1-a...
Literature References: Occurs together with plumieride and plumericin. Isoln from Plumeria acutifolia Poir., Apocynaceae, also from roots of P. rubra var alba: Grumbach et al., Experientia 8, 224 (1952). Structure: Schmid, Bencze, Helv. Chim. Acta 36, 206, 1468 (1953). Stereochemistry: Albers-Schönberg et al., ibid. 45, 1406 (1962). Synthesis: Büchi, Carlson, J. Am. Chem. Soc. 90, 5336 (1968); 91, 6470 (1969).

Cobaltous Arsenate CAS Registry Number: 7785-24-2

Additional Names: C.I. 77350
Percent Composition: As 32.96%, Co 38.89%, O 28.15%
Literature References: Octahydrate occurs in nature as erythrite or cobalt bloom. Prepn: Gmelins, Cobalt (8th ed.) 58, (part A), 305 (1932) and supplement, 752 (1961); Charles-Messance et al., Bull. Soc. Chim. Fr. 1962, 574. See Colour Index vol. 4 (3rd ed., 1971) p 4664.

Edotreotide CAS Registry Number: 204318-14-9 依多曲肽

CAS Name: N-[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]...
Literature References: Octapeptide analog of somatostatin, q.v. Designed for targeted radiotherapy vs somatostatin receptor-expressing tumors. Prepn: R. Albert et al., EP 714911; eidem, US 6183721 (1996, 2001 both to Novartis); idem, et al., Bioorg. Med. Chem. Lett. 8, 1207 (1998). Solution-phase synthesis: M. Schottelius et al., Tetrahedron Lett. 44, 2393 (2003). In vivo antineoplastic activity: B. Stolz et al., Eur. J. Nucl. Med. 25, 668 (1998). Receptor binding study: J. C. Reubi et al., ibid. 27, 273 (2000). Clinical pharmacokinetics: F. Jamar et al., Eur. J. Nucl. Med. Mol. Imaging 30, 510 (2003). Clinical evaluation in neuroendocrine tumors: C. Waldherr et al., J. Nucl. Med. 43, 610 (2002).

Octreotide CAS Registry Number: 83150-76-9 醋酸奥曲肽

CAS Name: D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2®7)-disulfide
Additional Names: 1,2-dithia-5,8,...
Literature References: Octapeptide analog of somatostatin, q.v. Prepn: W. Bauer, J. Pless, EP 29579; eidem, US 4395403 (1981, 1983 both to Sandoz); and pharmacology: W. Bauer et al., Life Sci. 31, 1133 (1982). Opiate antagonist properties: R. Maurer et al., Proc. Natl. Acad. Sci. USA 79, 4815 (1982). Inhibitory effect on human gastroenteropancreatic hormone secretion: M. E. Kraenzlin et al., Experientia 41, 738 (1985). Endocrine profile in humans: E. del Pozo et al., Acta Endocrinol. 111, 433 (1986). Clinical evaluation in acromegaly: G. Plewe et al., Lancet 2, 782 (1984); in autonomic neuropathy: R. D. Hoeldtke et al., ibid. 2, 602 (1986). Symposium on chemistry, pharmacology and clinical trials: Scand. J. Gastroenterol. 21, Suppl. 119, 1-274 (1986); on clinical evaluation in gastrointestinal endocrine tumors: Am. J. Med. 82, Suppl. 5B, 1-99 (1987).

Damascenine CAS Registry Number: 483-64-7 大马士革宁

CAS Name: 3-Methoxy-2-(methylamino)benzoic acid methyl ester
Additional Names: 2-(methylamino)-m-anisic acid methyl ester; methyl 2-(methylamino)-3-methoxybenzoate; methyldamascenine; nigelline...
Literature References: Odoriferous principle of oil of Nigella from seeds of Nigella damascena L. and Nigella arvensis L., Ranunculaceae. Early syntheses: Ewins, J. Chem. Soc. 101, 544 (1912); Kaufman, Rothlin, Ber. 49, 578 (1916); Sornet, Manuf. Chem. 5, 87 (1924); Keller, Schulze, Arch. Pharm. 263, 481 (1925). Improved synthesis: Mutschler, ibid. 298, 861 (1965); M. Thoinet et al., Ann. Pharm. Fr. 36, 337 (1978). Toxicity study: Bekemeier et al., Arch. Int. Pharmacodyn. Ther. 168, 199 (1967).