其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Bis[methylthio]methane CAS Registry Number: 1618-26-4 二甲硫基甲烷

Additional Names: Bis[methylmercapto]methane; methylenebis[methyl sulfide]
Percent Composition: C 33.29%, H 7.45%, S 59.25%
Literature References: Odorous principle of the white truffle Tuber magnatum (Pico) Vitt., Tuberaceae. Isoln: Fiecchi et al., Tetrahedron Lett. 1967, 1681. Synthesis from methyl mercaptan: Böhme, Marx, Ber. 74, 1672 (1941).

Tetrathiafulvalene CAS Registry Number: 31366-25-3 四硫富瓦烯

CAS Name: 2-(1,3-Dithiol-2-ylidene)-1,3-dithiole
Additional Names: D 2,2'-bi-1,3-dithiole; bis-1,3-dithiole; 1,4,5,8-tetrathiafulvalene; TTF
Percent Composition: C 35.26%, H 1.97%, S 62.76%
Literature References: Of interest in solid state chemistry as a conductor, catalyst or sensor due to its unusual electronic and magnetic properties. Primarily used as the parent compound for supramolecular assemblies. Prepn: F. Wudl et al., Chem. Commun. 1970, 1453. In combination with TCNQ (tetracyano-p-quinodimethane) to form first "organic metal": J. Ferraris et al., J. Am. Chem. Soc. 95, 948 (1973); electronic structure: R. Gleiter et al., J. Electron. Spectrosc. Relat. Phenom. 2, 207 (1973). Use as a catalyst in radical reactions: R. J. Fletcher et al., J. Chem. Soc. Perkin Trans. 1 1995, 623; J. A. Murphy, S. J. Roome, ibid. 1349. TTF-mediated biosensors for glucose: T. Yu et al., J. Appl. Polym. Sci. 58, 973 (1995); for NADH: X. Zhang et al., Anal. Commun. 33, 111 (1996); for gln and glu: A. Mulchandani, A. S. Bassi, Biosens. Bioelectron. 11, 271 (1996). Review: T. Jorgensen et al., Chem. Soc. Rev. 23, 41-51 (1994). Review of electrical properties and structural data of unsymmetric TTF cmpds: J. M. Fabre et al., Synth. Met. 35, 57-64 (1990); of role in superconductors: M. R. Bryce, J. Mater. Chem. 5, 1481-1496 (1995).

l-Menthone CAS Registry Number: 14073-97-3 5-甲基-2-(1-甲乙基)环已硐

CAS Name: (2S-trans)-5-Methyl-2-(1-methylethyl)cyclohexanone
Additional Names: (1R,4S)-(-)-p-menthan-3-one; 1-methyl-4-isopropylcyclohexan-3-one
Percent Composition: C 77.87%, H 11.76%, O 10...
Literature References: Of the four optically active isomers of methone, the one occurring most frequently in nature. Found in various volatile oils, such as pennyroyal, peppermint, geranium: Simonsen, The Terpenes vol. I (University Press, Cambridge, 2nd ed., 1947) pp 314-327. Prepd by chromic acid oxidation of l-menthol: Hussey, Baker, J. Org. Chem. 25, 1434 (1960); Brown, Garg, J. Am. Chem. Soc. 83, 2952 (1961).

Shark Liver Oil CAS Registry Number: 68990-63-6 鲨鱼肝油

Trademarks: Robecote (Robeco)
Literature References: Oil expressed from the livers of sharks and other Elasmobranchii species. Constit: Squalene, pristane, vitamins A and D, esters of fatty acids (esp. palmitic and oleic), glycerol ethers, triglycerides, cholesterol and fatty alcohols. Isoln: A. Ehrenreich, GB 284657 (1927); C. E. Brown, S. A. Reed, GB 1021542 (1966 to Marfleet Refining Co. Ltd.). Composition: N. A. Sörensen, J. Mehlum, Acta Chem. Scand. 2, 140 (1948); E. Gelpi, J. Oro, J. Am. Oil Chem. Soc. 45, 144 (1968); R. Lombardi et al., Ann. Pharm. Fr. 29, 429 (1971). Comparison with cod liver oil: A. O. Banjo, J. Food Technol. 14, 107 (1979).

Plicamycin CAS Registry Number: 18378-89-7 光辉霉素

CAS Name: Mithramycin
Additional Names: aureolic acid; mithracin; mitramycin; aurelic acid; antibiotic LA-7017
Percent Composition: C 57.55%, H 7.06%, O 35.39%
Literature References: Oligosaccharide antibiotic produced by Streptomyces argillaceus n. sp. and S. tanashiensis. Isoln: Grundy et al., Antibiot. Chemother. 3, 1215 (1953); Philip, Schenck, ibid. 1218; Rao et al., ibid. 12, 182 (1962). Identity of aureolic acid with mithramycin: Berlin et al., Nature 218, 193 (1968). Prepn: Gado et al., HU 155679 (1969 to Gyogyszerkutato Intezet), C.A. 70, 118093f (1969). Similar to the chromomycins and olivomycins, q.q.v. Structural elucidation of the aglycone, chromomycinone, and the carbohydrate moieties: Bakhaeva et al., Tetrahedron Lett. 1968, 3595; Berlin et al., Khim. Prir. Soedin. 1972, 537, 542, C.A. 78, 16436t, 16443t (1973). Revised structure: J. Thiem, B. Meyer, Tetrahedron 37, 551 (1981). NMR and fluorometric characterization: N. R. Krishna et al., J. Antibiot. 43, 1543 (1990). Metabolic studies: Kennedy et al., Cancer Res. 27, 1534 (1967). Mode of action studies: Kushch et al., Antibiotiki 17, 504 (1972). Toxicity study: M. Slavik, S. K. Carter, Adv. Pharmacol. Chemother. 12, 1 (1975). Review: J. D. Skarbek, M. K. Speedie in Antitumor Compounds of Natural Origin vol. 1, A. Aszalos, Ed. (CRC Press, Boca Raton, 1981) pp 191-235.

Verbascose CAS Registry Number: 546-62-3 毛蕊花糖

CAS Name: b-D-Fructofuranosyl O-a-D-galactopyranosyl-(1®6)-O-a-D-galactopyranosyl(1®6)-O-a-D-galactopyranosyl-(1®6)-a-D-glucopyranoside
Additional Names: O-a-D-galactopyranosyl-(1®6)-[O-a-D-gal...
Literature References: Oligosaccharide isolated from roots of mullein Verbascum thapsus L., Scrophulariaceae: Bourquelot, Bridel, Compt. Rend. 151, 760 (1910); from birch wood, Betula verrucosa Ehrh., Betulaceae: Lindberg, Selleby, Acta Chem. Scand. 12, 1512 (1958). Structure: Wickström et al., Bull. Soc. Chim. Fr. 1956, 827. Review: D. French "The Raffinose Family of Oligosaccharides" in Adv. Carbohydr. Chem. 9, 180-181 (1954).

Paromomycin CAS Registry Number: 7542-37-2 巴龙霉素

CAS Name: O-2-Amino-2-deoxy-a-D-glucopyranosyl-(1®4)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®3)-b-D-ribofuranosyl-(1®5)]-2-deoxy-D-streptamine
Additional Names: O-2,6-diamino-2,6-dideo...
Literature References: Oligosaccharide-type antibiotic isolated from various Streptomyces. From S. rimosus forma paromomycinus: Frohardt et al., US 2916485 (1959 to Parke, Davis); from S. catenulae: Davisson, Finlay, US 2895876 (1959 to Pfizer); from S. chrestomyceticus: Canevazzi, Scotti, G. Microbiol. 7, 242 (1959); Arcamone et al., ibid. 251. Identity of paromomycin, catenulin, hydroxymycin and aminosidine: Schillings, Schaffner, Antimicrob. Agents Chemother. 1961, 274. Structure: Haskell et al., J. Am. Chem. Soc. 81, 3480, 3482 (1959); Rinehart et al., ibid. 84, 3218 (1962); Hichens, Rinehart, ibid. 85, 1547 (1963). Probable identity with zygomycin A: Horii, J. Antibiot. 15A, 187 (1962). Identity with monomycin A: Konstantinova, Brazhnikova, Antibiotiki 10(1), 34 (1965); with neomycin E: Hessler et al., J. Antibiot. 23, 464 (1970). Toxicity data: A. DiMarco, C. Bertazzoli, Antibiot. Chemother. 11, 2 (1963). Review of antimicrobial activity: G. L. Coffey et al., ibid. 9, 730 (1959). Review of pharmacology: Gasparini, Pignatelli, Veterinaria (Milan) 21, 7 (1972).

Docosahexaenoic Acid CAS Registry Number: 6217-54-5 二十二碳六烯酸

CAS Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Additional Names: cervonic acid; doconexent; DHA
Percent Composition: C 80.44%, H 9.82%, O 9.74%
Literature References: Omega-3 fatty acid found in marine fish oils and in many phospholipids. Major structural component of excitable membranes of the retina and brain; synthesized in the liver from a-linolenic acid, q.v. Isoln from oil of Sardina ocellata J. and structure: J. M. Whitcutt, Biochem. J. 67, 60 (1957). Improved isoln from cod liver oil: S. W. Wright et al., J. Org. Chem. 52, 4399 (1987). Effect on brain and behavioral development: P. E. Wainwright, Neurosci. Biobehav. Rev. 16, 193 (1992). Review of uptake and metabolism by retinal cells: N. G. Bazan, E. B. Rodriguez de Turco, J. Ocul. Pharmacol. 10, 591-603 (1994). Review of clinical studies in infant formula supplementation: M. Makrides et al., Lipids 31, 115-119 (1996).

Propylure CAS Registry Number: 10297-61-7 [(5E)-10-丙基十三-5,9-二烯基]乙酸酯

CAS Name: (E)-10-Propyl-5,9-tridecadien-1-ol acetate
Additional Names: trans-1-acetoxy-10-(n-propyl)trideca-5,9-diene; 10-propyl-trans-5,9-tridecadienyl acetate
Percent Composition: C 77.09%...
Literature References: Once thought to be the sex pheromone of the pink bollworm moth, Pectinophora gossypiella (Saunders), a destructive cotton pest: H. E. Hummel et al., Science 181, 873 (1973), cf. Gossyplure. Reported as the first known natural product possessing di-n-propyl branching. Isoln, structure, and synthesis: Jones et al., Science 152, 1516 (1966). Improved total syntheses: Pattenden, J. Chem. Soc. C 1968, 2385; Meyers, Collington, Tetrahedron 27, 5979 (1971); Vig et al., J. Indian Chem. Soc. 50, 39 (1973); K. Utimoto et al., Tetrahedron Lett. 1975, 4233. Photochemical synthesis: Kossanyi et al., ibid. 1973, 3459. Stereoselective synthesis: A. Alexakis et al., ibid. 1978, 2027. trans-Propylure is rendered inactive by the presence of 15% of the cis-isomer: Jacobson, Science 163, 190 (1969).

Sedecamycin CAS Registry Number: 23477-98-7 西地霉素

CAS Name: (2S)-N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-13-(Acetyloxy)-7-hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide
Additional...
Literature References: One of 7 components of antibiotic T-2636. First isolated as bundlin B from Streptomyces griseofuscus: J. M. J. Sakamoto et al., J. Antibiot. A15, 98 (1962). Isoln from S. rochei var volubilis: NL 6807119; E. Higashide et al., US 3626055 (1968, 1971 both to Takeda); eidem, J. Antibiot. 24, 1 (1971); S. Harada et al., ibid. 13. Similar to lankacidin which is isolated from S. violaceoniger with lankamycin. Structure, absolute configuration and identity with bundlin B: H. Harada et al., Tetrahedron Lett. 10, 2239 (1969); K. Kamiya et al., ibid. 2245; M. Uramoto et al., ibid. 2249. Enzymatic conversion to other lankacidins: T. Fugono et al., Experientia 26, 26 (1970). Antibacterial activity: K. Tsuchiya et al., J. Antibiot. 24, 29 (1971). Mass spectra: M. Uramoto et al., Agric. Biol. Chem. 38, 855 (1974). Biosynthetic studies: eidem, J. Am. Chem. Soc. 100, 3616 (1978); K. Kakinima et al., Tetrahedron Lett. 23, 5303 (1982). Synthetic study: M. J. Fray, E. J. Thomas, Tetrahedron 40, 673 (1984). Activity against Treponema hyodysenteriae (swine dysentery): BE 891275; N. Narukawa et al., US 4425356 (1982, 1984 both to Takeda).