其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Glutamine CAS Registry Number: 56-85-9 L-谷氨酰胺

CAS Name: L-Glutamine
Additional Names: Gln; Q; 2-aminoglutaramic acid; (S)-2,5-diamino-5-oxopentanoic acid; glutamic acid 5-amide
Trademarks: Cebrogen (Walker); Glumin; Levoglutamina; Stimu...
Literature References: Non-essential amino acid for human development; most abundant free amino acid in plasma and tissue. Isoln from sugarbeet juice: E. Schulze, E. Bosshard, Ber. 16, 312 (1883). Due to ease of conversion to glutamic acid, q.v., it was not isolated from protein until 1932: M. Damodoran et al., Biochem. J. 26, 1704 (1932). Early chemistry and biochemistry: R. M. Archibald, Chem. Rev. 37, 161-208 (1945); Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vol 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 1929-1954, passim. HPLC determn in biotech samples: B. Polanuer et al., J. Chromatogr. 594, 173 (1992). Review of nutritive needs: R. J. Smith, D. W. Wilmore, J. Parenter. Enteral Nutr. 14, (Suppl.) 94S-99S (1990); and metabolism: W. W. Souba, J. Nutr. Biochem. 4, 2-9 (1993); L. M. Castell et al., Amino Acids 7, 231-243 (1994). Review of metabolism and physiologic implications: R. J. Smith, J. Parenter. Enteral Nutr. 14, (Suppl.) 40S-44S (1990); B. Moskovitz et al., Pharmacol. Res. 30, 61-71 (1994).

Alclometasone CAS Registry Number: 67452-97-5 阿氯米松

CAS Name: (7a,11b,16a)-7-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 7a-chloro-16a-methylprednisolone
Percent Composition: C 64.62%, H 7.15%, Cl 8.67%, ...
Literature References: Non-fluorinated corticosteroid with low systemic effects. Prepn: M. J. Green et al., US 4076708; M. J. Green, H. J. Shue, US 4124707 (both 1978 to Schering); M. J. Green et al., J. Steroid Biochem. 11, 61 (1979); H. J. Shue et al., J. Med. Chem. 23, 430 (1980). Topical anti-inflammatory activity of the 17,21-dipropionate: B. Lutsky et al., Arzneim.-Forsch. 29, 992 (1979); M. J. Green et al., ibid. 30, 1618 (1980).

Budesonide CAS Registry Number: 51333-22-3 布地奈德

CAS Name: (11b,16a)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
Additional Names: (R,S)-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with ...
Literature References: Non-halogenated glucocorticoid related to triamcinolone hexacetonide, q.v. with a high ratio of topical to systemic activity. Prepn: R. L. Brattsand et al., DE 2323215; eidem, US 3929768 (1973, 1975 both to Bofors). Synthesis and anti-inflammatory properties: A. Thalén, R. L. Brattsand, Arzneim.-Forsch. 29, 1787 (1979). Pharmacokinetic study: A. Ryrfeldt et al., J. Steroid Biochem. 10, 317 (1979). HPLC determn of epimers, impurities, content: G. Roth et al., J. Pharm. Sci. 69, 766 (1980). Review of pharmacodynamics and efficacy in asthma and rhinitis: S. P. Clissold, R. C. Heel, Drugs 28, 485-518 (1984).

Valspodar CAS Registry Number: 121584-18-7 伐司扑达

CAS Name: 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
Additional Names: [3'-desoxy-3'-oxo-MeBmt]1-[Val]2-cyclosporin; [3'-keto-Bmt1]-[Val2]-cyclosporinTrademarks:...
Literature References: Nonimmunosuppressive cyclosporin analog that reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein, q.v. Prepn: P. Bollinger et al., EP 296122; eidem, US 5525590 (1988, 1996 both to Sandoz). Pharmacology: D. Boesch et al., Exp. Cell Res. 196, 26 (1991). Clinical pharmacokinetics: R. M. Lush et al., J. Clin. Pharmacol. 37, 123 (1997). HPLC determn in blood: M. G. Scott et al., Clin. Chem. 43, 505 (1997). Clinical evaluation in multiple myeloma: P. Sonneveld et al., Leukemia 10, 1741 (1996); in acute myelogenous leukemia: R. Advani et al., Blood 93, 787 (1999). Review of pharmacology and clinical efficacy: F. Loor, Expert Opin. Invest. Drugs 8, 807-835 (1999).

Dronedarone CAS Registry Number: 141626-36-0 决奈达隆

CAS Name: N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide
Additional Names: N,N-dibutyl-3-[4-[(2-butyl-5-methylsulfonamido)benzofuran-3-ylcarbonyl]phenoxy]pr...
Literature References: Noniodinated analog of amiodarone, q.v. Prepn: J. Gubin et al., EP 471609; eidem, US 5223510 (1992, 1993 both to Sanofi). Hemodynamic and antiadrenergic effects in dogs: L. Djandjighian et al., J. Cardiovasc. Pharmacol. 36, 376 (2000). Electrophysiological effects in canine heart: A. Varró et al., Br. J. Pharmacol. 133, 625 (2001). Clinical pharmacokinetics and interaction with metoprolol, q.v.: T. Damy et al., Fundam. Clin. Pharmacol. 18, 113 (2004). Clinical evaluation in atrial fibrillation: P. Touboul et al., Eur. Heart J. 24, 1481 (2003).

n-Octyl- b - D -glucoside CAS Registry Number: 29836-26-8 辛基-beta-D-吡喃葡萄糖苷

CAS Name: Octyl-b-D-glucopyranoside
Additional Names: n-octylglucoside; OG
Percent Composition: C 57.51%, H 9.65%, O 32.83%
Literature References: Nonionic detergent primarily used for solubilizing membrane-bound proteins. Prepn: C. R. Noller, C. W. Rockwell, J. Am. Chem. Soc. 60, 2076 (1938). Partition behavior between water and membrane phases: M. Ueno, Biochemistry 28, 5631 (1989); thermodynamics and structural impact: M. R. Wenk et al., Biophys. J. 72, 1719 (1997). Solubilzation and reconstitution of liposomes: O. López et al., J. Phys. Chem. B 105, 9879 (2001). Solubilization of lipid vesicles: A. Meister, A. Blume, Phys. Chem. Chem. Phys. 6, 1551 (2004). Micelle formation: A. Walter et al., Biochim. Biophys. Acta 1508, 20 (2000); in mixed systems: A. Lainez et al., Langmuir 20, 5745 (2004).

Tyloxapol CAS Registry Number: 25301-02-4 四丁酚醇

CAS Name: 4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane
Additional Names: oxyethylated tertiary octylphenol formaldehyde polymer; p-isooctylpolyoxyethylenephenol form...
Literature References: Nonionic detergent with surface-tension-reducing properties. Prepn: Bock, Rainey, US 2454541 (1948 to Rohm Haas); J. W. Cornforth et al., Nature 168, 150 (1951). Use to induce exptl hyperlipidemia: A. Kellner et al., J. Exp. Med. 93, 373 (1951); P. E. Schurr et al., Lipids 7, 68 (1972). Use as ophthalmic excipient: D. E. Guttman et al., J. Pharm. Sci. 50, 305 (1961). Phase behavior of mixtures with water: K. Westesen, Int. J. Pharm. 102, 91 (1994); K. Westesen, M. H. J. Koch, ibid. 103, 225 (1994). Tissue distribution and excretion: R. L. DeAngelis et al., Xenobiotica 25, 521 (1995).

Gadoversetamide CAS Registry Number: 131069-91-5 钆8,11-二(羧酸甲基)-14-{2-[(2-甲氧基乙基)氨基]-2-氧代乙基}-6-氧代-2-氧杂-5,8,11,14-四氮杂十六烷-16-酸酯

CAS Name: [8,11-Bis(carboxymethyl)-14-[2-[(2-methoxyethyl)amino]-2-oxoethyl]-6-oxo-2-oxa-5,8,11,14-tetraazahexadecan-16-oato(3-)]gadolinium
Additional Names: [N,N''-bis[N-(2-methoxyethyl)-carba...
Literature References: Nonionic paramagnetic contrast agent. Prepn: R. W. Weber, M. P. Periasamy, WO 9001024; R. W. Weber, US 5130120 (1990, 1992 both to Mallinckrodt); M. Periasamy et al., Invest. Radiol. 26, S217 (1991). Paramagentic profile: K. Adzamli et al., ibid. 34, 410 (1999). Clinical pharmacokinetics: S. K. Swan et al., J. Magn. Reson. Imaging 9, 317 (1999). Clinical study in liver imaging: D. L. Rubin et al., ibid. 240; in CNS imaging: R. I. Grossman et al., Invest. Radiol. 35, 412 (2000).

Nonoxynol CAS Registry Number: 26027-38-3 聚乙二醇单-4-壬苯醚n≈5

CAS Name: a-(4-Nonylphenyl)-w-hydroxypoly(oxy-1,2-ethanediyl)
Additional Names: polyethyleneglycols mono(nonylphenyl) ether; macrogol nonylphenyl ether; nonoxinol; polyoxyethylene(n)nonylphenyl...
Literature References: Nonionic surfactant mixtures prepd by reacting nonylphenol with ethylene oxide. Prepn of polyoxyethylated alkyl phenols: A. Steindorff et al., US 2213477 (1940 to GAF). Average number of ethylene oxide units (n) per molecule is indicated by number following nonoxynol (e.g. nonoxynol-15 for n = 15). Trademarks for nonoxynol series include Conco NI (Continental Chem.) , Dowfax 9N (Dow) , Igepal CO (Rhone-Poulenc) , Makon, Neutronyx 600's (Onyx) , Nonipol NO (Sankyo) , Polytergent B (Olin) , Renex 600's (Atlas) , Solar NP (Swift) , Sterox (Monsanto) , Surfonic N (Jefferson) , T-DET-N (Thompson-Hayward) , Tergitol NP (Union Carbide) , Triton N (Rohm Haas) . Individual members of series indicated by numerical suffixes. Toxicology study: H. F. Smyth Jr., J. C. Calandra, Toxicol. Appl. Pharmacol. 14, 315 (1969). Inactivation of HIV in vitro by nonoxynol-9: M. Malkovsky et al., Lancet 1, 645 (1988). Clinical evaluation of nonoxynol-9 in sexually transmitted diseases: W. C. Louv et al., J. Infect. Dis. 158, 518 (1988). Review: C. R. Enyeart, "Polyoxyethylene Alkylphenols" in Nonionic Surfactants, M. J. Schick, Ed. (Dekker, New York, 1967) pp 44-85.

Hydroxypropyl Cellulose CAS Registry Number: 9004-64-2 羟丙基纤维素

CAS Name: Cellulose 2-hydroxypropyl ether
Additional Names: oxypropylated cellulose
Trademarks: Klucel (Hercules); Lacrisert (Merck Co.)
Literature References: Nonionic water soluble ether of cellulose, q.v. that produces solns having a wide range of viscosity (200-2500 cp). Prepn: NL 6401036; E. D. Klug, US 3278520, US 3278521 (1964, 1966, 1966 all to Hercules). Use in the treatment of dry eye syndrome: T. P. Werblin et al., Ophthalmology 88, 78 (1981); P. Huguet et al., Bull. Soc. Ophthalmol. Fr. 81, 1173 (1981). Review of chemistry, physical properties and uses: E. D. Klug in Encyclopedia of Polymer Science and Technology vol. 15 (Interscience, New York, 1971) pp 307-314; A. J. Desmarais, Industrial Gums, R. L. Whistler, Ed. (Academic Press, New York, 2nd ed., 1973) pp 649-672.