其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Lodoxamide CAS Registry Number: 53882-12-5 诺朵腊酸

CAS Name: 2,2'-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis(2-oxoacetic acid)
Additional Names: N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid
Percent Composition: C 42.40%, H 1.94%, Cl 11...
Literature References: Mast cell stabilizer. Prepn: C. M. Hall, J. B. Wright, DE 2362409; eidem, US 3993679 (1974, 1976 both to Upjohn); J. B. Wright et al., J. Med. Chem. 21, 930 (1978). HPLC determn in human plasma: I. L. Honigberg et al., J. Chromatogr. 276, 213 (1983). Mechanism of action study: M. K. Church, J. Hiroi, Br. J. Pharmacol. 90, 421 (1987). Clinical evaluation in asthma: R. L. Case et al., J. Am. Med. Assoc. 247, 661 (1982); in allergic eye disease: G. T. Fahy et al., Eur. J. Ophthalmol. 2, 144 (1992).

Nedocromil CAS Registry Number: 69049-73-6 奈多罗米

CAS Name: 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Additional Names: 4,6-dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic aci...
Literature References: Mast cell stabilizer; also modulates production of cytokines by stimulated epithelial cells. Prepn and pharmacology: H. Cairns, D. Cox, BE 866622; eidem, US 4474787 (1978, 1984 both to Fisons); H. Cairns et al., J. Med. Chem. 28, 1832 (1985). Series of articles on pharmacology, pharmacokinetics and clinical profile in allergic rhinitis: Allergy 51, Suppl. 28, 8-34 (1996). Comparative clinical trial with cromolyn sodium, q.v., in asthma: H. J. Schwartz et al., Chest 109, 945 (1996).

Sulphenone CAS Registry Number: 80-00-2 对氯苯基苯基砜

CAS Name: 1-Chloro-4-(phenylsulfonyl)benzene
Additional Names: p-chlorophenyl phenyl sulfone; 4-chlorodiphenyl sulfone; sulfenonePercent Composition: C 57.03%, H 3.59%, Cl 14.03%, O 12.66%, S 1...
Literature References: May also contain 20% related diaryl sulfones. Prepn: Bender, Pitt, US 2593001 (1952 to Stauffer Chem.). Toxicology: L. W. Hazleton et al., J. Agric. Food Chem. 3, 836 (1955).

Phthalylsulfathiazole CAS Registry Number: 85-73-4 酞磺胺噻唑

CAS Name: 2-[[[4-[(2-Thiazolylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid
Additional Names: 4'-(2-thiazolylsulfamyl)phthalanilic acid; 2-(N4-phthalylaminobenzenesulfonamido)thiazole; 2-(N...
Literature References: May be prepd by condensing sulfathiazole with phthalic anhydride: M. L. Moore, US 2324013; US 2324015 (1943 to Sharp Dohme). Prepn of 8-hydroxyquinoline salt: DE 1008296 (1957 to Geistlich Söhne). Toxicity data: P. A. Mattis et al., J. Pharmacol. Exp. Ther. 81, 116 (1944).

Gold Monocyanide CAS Registry Number: 506-65-0 氰化亚金

Additional Names: Aurous cyanide; gold cyanide
Percent Composition: C 5.39%, Au 88.33%, N 6.28%
Literature References: May be prepd by decompn of Na[Au(CN)2] with HCl: Wogrinz, Metalloberflaeche 8, B162 (1954).

Tromethamine CAS Registry Number: 77-86-1 三(羟甲基)氨基甲烷

CAS Name: 2-Amino-2-hydroxymethyl-1,3-propanediol
Additional Names: trimethylol aminomethane; tris(hydroxymethyl)aminomethane; trisamine; tris buffer; trometamol; tromethane; TRIS
Trademarks...
Literature References: May be prepd by reduction or catalytic hydrogenation of the corresp nitro compd. Prepn of similar compds: Hass, Vanderbilt, US 2174242 (1940); Johnson, Degering, J. Org. Chem. 8, 7 (1943); Boileau, Mem. Poudres 35, Annexe 7-76 (1953). Prepn by electrolytic reduction: McMillan, US 2485982 (1949 to Comm. Solvents Corp.). Titrimetric standard: Whitehead, J. Chem. Educ. 36, 297 (1959). Monograph: Ann. N.Y. Acad. Sci. 92, Art. 2, pp 333-812 (June 17, 1961). Crystal structure: R. Rudman et al., Science 200, 531 (1978). GC determn in plasma: H. Hulshoff, H. B. Kostenbauder, J. Chromatogr. 145, 155 (1978). Pharmacokinetics in rabbits: H. Brasch, H. Iven, Arch. Int. Pharmacodyn. 254, 4 (1981). Use as a biological buffer: R. A. Durst, B. R. Staples, Clin. Chem. 18 206 (1972); S. P. Fling, D. S. Gregerson, Anal. Biochem. 155, 83 (1986); T. Higa, D. M. Desiderio, ibid. 173, 463 (1988). Interaction with hydroxyl radicals: M. Hicks, J. M. Gebicki, FEBS Lett. 199, 92 (1986). Review of clinical experience in treatment of acidemia: G. G. Nahas et al., Drugs 55, 191-224 (1998).

Pridinol CAS Registry Number: 511-45-5 二苯帕诺

CAS Name: a,a-Diphenyl-1-piperidinepropanol
Additional Names: 1,1-diphenyl-3-piperidino-1-propanol; 3-piperidino-1,1-diphenyl-1-propanol; 1,1-diphenyl-3-(1-piperidyl)-1-propanol; 3-(N-piperidyl...
Literature References: May be prepd from ethyl 1-piperidinepropionate and phenylmagnesium bromide: Adamson, GB 624118 (1949 to Wellcome Found.). Toxicity study: R. W. Cunningham et al., J. Pharmacol. Exp. Ther. 96, 151 (1949).

Isobutyl Mercaptan CAS Registry Number: 513-44-0 异丁硫醇

CAS Name: 2-Methyl-1-propanethiol
Percent Composition: C 53.27%, H 11.18%, S 35.55%
Literature References: May be prepd from isobutyl bromide and KHS in alcohol, see ref under other butyl mercaptans.

Styphnic Acid CAS Registry Number: 82-71-3 2,4,6-三硝基间苯二酚,收敛酸

CAS Name: 2,4,6-Trinitro-1,3-benzenediol
Additional Names: 2,4,6-trinitroresorcinol; 2,4-dihydroxy-1,3,5-trinitrobenzene
Percent Composition: C 29.40%, H 1.23%, N 17.14%, O 52.22%
Literature References: May be prepd from natural sources, such as Pernambuco wood extract or quebracho extract by the action of nitric acid: Einbeck, Jablonski, Ber. 54, 1086 (1921). Prepd industrially by first sulfonating, then nitrating resorcinol: Merz, Zetter, Ber. 12, 681, 2037 (1879); Datta, Varma, J. Am. Chem. Soc. 41, 2043 (1919). Prepd by nitrating 2,4-dinitroresorcinol: Kametani, Ogasawara, Chem. Pharm. Bull. 15, 893 (1967).

Ammonium Uranium Carbonate CAS Registry Number: 18077-77-5

CAS Name: (HB-8-22-111'1'1''1'')-Tetraammonium tris[carbonato(2-)-kO,kO']dioxouranate(4-)
Additional Names: ammonium dioxotricarbonatouranate(VI); uranium ammonium carbonate; uranyl ammonium ca...
Literature References: May contain 2H2O.