其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Colfosceril Palmitate CAS Registry Number: 63-89-8 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱

CAS Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-trioxa-4-phosphapentacosan-1-aminium inner salt 4-oxide
Additional Names: L-a-dipalmitoyl lecithin; dipalmitoyl-L-a...
Literature References: Major phospholipid constituent and primary surface tension lowering component of natural lung surfactant. Isoln from lung extracts: S. J. Thannhauser et al., J. Biol. Chem. 166, 669 (1946); E. S. Brown, Am. J. Physiol. 207, 402 (1964). Enantioselective synthesis: E. Baer, M. Kates, J. Am. Chem. Soc. 72, 942 (1950). Clinical study in combination therapy for neonatal respiratory distress syndrome (RDS): C. J. Morley et al., Lancet 1, 64 (1981). Diagnostic use as predictor of fetal lung maturity: A. Lohninger et al., Clin. Chem. 29, 650 (1983). HPTLC determn in amniotic fluid: J. G. Alvarez et al., J. Chromatogr. B 665, 79 (1995). Review of early literature: D. F. Tierney, Am. J. Physiol. 257, L1-L12 (1989); of role in pulmonary function and clinical use: L. M. G. van Golde et al., Physiol. Rev. 68, 374-455 (1988); of structure and function as surface active agent: B. A. Hills, Br. J. Anaesth. 65, 13-29 (1990); of biosynthesis: H. P. Haagsman, L. M. G. van Golde, Annu. Rev. Physiol. 53, 441-464 (1991).

Dehydroepiandrosterone CAS Registry Number: 53-43-0 去氢表雄酮

CAS Name: (3b)-3-Hydroxyandrost-5-en-17-one
Additional Names: prasterone; dehydroisoandrosterone; trans-dehydroandrosterone; D5-androsten-3b-ol-17-one; DHEA
Percent Composition: C 79.12%, H ...
Literature References: Major secretory steroidal product of the adrenal gland; secretion progressively declines with aging. May have estrogen- or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione, q.v. Isoln from male urine: Butenandt, Tscherning, Z. Physiol. Chem. 229, 167 (1934); Butenandt, Dannenbaum, ibid. 192. Prepn from cholesterol: Butenandt et al., ibid. 237, 57 (1935); Ruzicka, Wettstein, Helv. Chim. Acta 18, 986 (1935); Wallis, Fernholz, J. Am. Chem. Soc. 57, 1379, 1504 (1935); Schoeller et al., Naturwissenschaften 23, 337 (1935); from sitosterol: Oppenauer, Nature 135, 1039 (1935). High yield prepn: H. Hosoda et al., J. Org. Chem. 38, 4209 (1973). Metabolism study: P. Knapstein et al. Acta Endocrinol. 58, 261 (1968). Toxicity study of the sulfate: M. Yahara et al., J. Toxicol. Sci. 2, 161 (1977). Clinical evaluation in hormone replacement therapy: A. J. Morales et al., J. Clin. Endocrinol. Metab. 78, 1360 (1994); in systemic lupus erythematosus: R. F. van Vollenhoven et al., Arthritis Rheum. 38, 1826 (1995). Review of physiological importance: P. Ebeling, V. A. Koivisto, Lancet 343, 1479-1481 (1994). Symposium on role in aging: Ann. N.Y. Acad. Sci. 774, 1-350 (1995). Review of therapeutic potential: B. Allolio, W. Arlt, Trends Endocrinol. Metab. 13, 288-294 (2002).

Friedelin CAS Registry Number: 559-74-0 无羁萜,木栓酮

CAS Name: D:A-Friedooleanan-3-one
Additional Names: friedelan-3-one
Percent Composition: C 84.44%, H 11.81%, O 3.75%
Literature References: Major triterpene constituent of cork, obtained by extraction of ground cork with alc. Isoln: Istrati, Ostrogovich, Compt. Rend. 128, 1581 (1899). Isolated also from Ceratopetalum apetalum D. Don, Cunoniaceae: Jefferies, J. Chem. Soc. 1954, 473. Structure, sterochemistry: Brownlie et al., Chem. Ind. (London) 1955, 1156; Kane, Stevenson, Tetrahedron 15, 223 (1961); Stevenson, J. Org. Chem. 28, 188 (1963). Total synthesis of (±)-form: R. E. Ireland, D. M. Walba, Tetrahedron Lett. 1976, 1071.

Geosmin CAS Registry Number: 19700-21-1 二甲萘烷醇

CAS Name: [4S-(4a,4aa,8ab)]-Octahydro-4,8a-dimethyl-4a(2H)-naphthalenol
Additional Names: octahydro-4a,8ab-dimethyl-4aa(2H)-naphthol; 1,10-trans-dimethyl-trans-(9)-decalol
Percent Compositio...
Literature References: Major volatile component of beet essence, also determined to be the potent earthy odor contaminant of fish, beans, water: A. C. Thaysen, Ann. Appl. Biol. 23, 99 (1936); J. Silvey, A. W. Roach, J. Am. Water Works Assoc. 56, 60 (1964); A. A. Rosen et al., Water Treat. Exam. 19 (Pt. 2), 106 (1970); R. G. Buttery et al., J. Agric. Food Chem. 24, 419, 1246 (1976). Isoln from Actinomyetes, algae: N. N. Gerber, H. A. Lechevalier, Appl. Microbiol. 13, 935 (1965); A. A. Rosen et al., ibid. 16, 178 (1968); R. S. Safferman et al., Environ. Sci. Technol. 1, 429 (1967). Isoln from beets: K. E. Murray, P. A. Bannister, Chem. Ind. (London) 1975, 973; L. D. Tyler et al., J. Agric. Food Chem. 26, 1466 (1978). Structure: N. N. Gerber, Biotechnol. Bioeng. 9, 321 (1967); eidem, Tetrahedron Lett. 1968, 2971. Biological degradation: L. V. Narayan, W. J. Nunez, J. Am. Water Works Assoc. 66 (Pt. 1), 532 (1974).

Jacobsen's Catalyst CAS Registry Number: 149656-63-3 雅可布逊晶体

CAS Name: (SP-5-13)-Chloro[[rel-2,2'-[(1R,2R)-1,2-cyclohexanediylbis[(nitrilo-kN)methylidyne]]bis[4,6-bis(1,1'-dimethylethyl)phenolato-kO]](2-)]manganese
Percent Composition: C 68.07%, H 8.25%,...
Literature References: Manganese-salen Schiff base complex used as a catalyst in asymmetric syntheses. Prepn: E. N. Jacobsen et al., J. Am. Chem. Soc. 113, 7063 (1991); large-scale: J. F. Larrow et al., J. Org. Chem. 59, 1939 (1994). Synthesis and enantioselectivity of dimer: K. B. M. Janssen et al., Tetrahedron: Asymmetry 8, 3481 (1997). HPLC determn of enantiomeric purity in commercial samples: J. Zukowski, Chirality 10, 362 (1998). Mechanism of asymmetric epoxidation of indenes: D. L. Hughes et al., J. Org. Chem. 62, 2222 (1997). Use in epoxidation of isoflavones: W. Adam et al., Tetrahedron: Asymmetry 9, 1121 (1998).

Dimethyl(methylene)ammonium Iodide CAS Registry Number: 33797-51-2 N,N-二甲基亚甲基碘化铵

CAS Name: N-Methyl-N-methylenemethanaminium iodide
Additional Names: Eschenmoser's salt
Percent Composition: C 19.48%, H 4.36%, I 68.59%, N 7.57%
Literature References: Mannich type intermediate originally developed to introduce methyl groups into corrin chromophore. Prepn from trimethylamine and diiodomethane: J. Schreiber et al., Angew. Chem. Int. Ed. 10, 330 (1971); from N,N,N¢,N¢-tetramethylmethylenediamine: T. A. Bryson et al., J. Org. Chem. 45, 524 (1980). Used in prepn of Mannich bases: J. Hooz, J. N. Bridson, J. Am. Chem. Soc. 95, 602 (1973). In functionalization of indoles: A. P. Kozikowski, H. Isida, Heterocycles 14, 55 (1980). In prepn of a-methylene carbonyls: J. L. Roberts et al., Tetrahedron Lett. 1977, 1621; of terminal olefins: eidem, ibid. 1299.

sym-Tetrabromoethane CAS Registry Number: 79-27-6 四溴乙烷

CAS Name: 1,1,2,2-Tetrabromoethane
Additional Names: acetylene tetrabromide; Muthmann's liquid
Percent Composition: C 6.95%, H 0.58%, Br 92.47%
Literature References: Manuf by bromination of acetylene: GB 889649 (1962 to Associated Ethyl Co.). Toxicity studies: Gray, Arch. Ind. Hyg. Occup. Med. 2, 407 (1950); D. L. Wolff, Acta Biol. Med. Ger. 41, 945 (1982).

Tetrachloroethane CAS Registry Number: 79-34-5 四氯乙烷

CAS Name: 1,1,2,2-Tetrachloroethane
Additional Names: sym-tetrachloroethane; acetylene tetrachloride
Trademarks: Cellon; Bonoform
Percent Composition: C 14.31%, H 1.20%, Cl 84.49%
Literature References: Manuf by catalytic addition of chlorine to acetylene: Peters, Neumann, Angew. Chem. 45, 261 (1932); by chlorination of ethylene: Pye, US 2752402 (1956 to Dow); by catalytic chlorination of ethane: Joseph, US 2752401 (1956 to Dow); by chlorination of 1,2-dichloroethane: Conrad, US 2725412 (1955 to Ethyl Corp.); Fox, US 2846484 (1958 to Monsanto). Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969). Review of toxicology and human exposure: Toxicological Profile for 1,1,2,2-Tetrachloroethane (PB97-121099, 1996) 186 pp.

Aldol CAS Registry Number: 107-89-1 3-羟基丁醛

CAS Name: 3-Hydroxybutanal
Additional Names: 3-hydroxybutyraldehyde; acetaldol
Percent Composition: C 54.53%, H 9.15%, O 36.32%
Literature References: Manuf by condensation of acetaldehyde in aq NaOH: Alhéritière, Gobron, US 2713598 (1955 to Usines de Melle). Toxicity study: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).

o-Aminophenol CAS Registry Number: 95-55-6 邻氨基苯酚

CAS Name: 2-Aminophenol
Additional Names: 2-amino-1-hydroxybenzene; 2-hydroxyaniline
Percent Composition: C 66.04%, H 6.47%, N 12.83%, O 14.66%
Literature References: Manuf by reduction of o-nitrophenol: Freifelder, Robinson, US 3079435 (1963 to Abbott).