其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Potassium Xanthogenate CAS Registry Number: 140-89-6 乙基黄原酸钾

CAS Name: Carbonodithioic acid O-ethyl ester potassium salt
Additional Names: ethylxanthic acid potassium salt; potassium ethyldithiocarbonate; potassium ethylxanthogenate; potassium ethylxanth...
Literature References: Made by treating an alcoholic soln of CS2 with alcoholic KOH. Usually contains 8-10% H2O.

Dulcin CAS Registry Number: 150-69-6 (4-乙氧基苯基)脲

CAS Name: (4-Ethoxyphenyl)urea
Additional Names: p-phenetolcarbamide; p-phenetylurea
Trademarks: Sucrol; Valzin
Percent Composition: C 59.99%, H 6.71%, N 15.55%, O 17.76%
Literature References: Made by treating p-phenetidine with phosgene and then with ammonia: Berlinerblau, J. Prakt. Chem. 30, 103 (1883); from p-phenetidine and urea: Kurzer, Org. Synth. coll. vol. IV, 52 (1963).

p-Toluenesulfonyl Chloride CAS Registry Number: 98-59-9 对甲苯磺酰氯(PTSC)

Additional Names: Tosyl chloride
Percent Composition: C 44.10%, H 3.70%, Cl 18.60%, O 16.78%, S 16.82%
Literature References: Made by treating toluene with chlorosulfonic acid.

Thiosinamine CAS Registry Number: 109-57-9 丙烯基脲

CAS Name: (2-Propenyl)thiourea
Additional Names: allyl thiourea; allylthiocarbamide
Trademarks: Aminosin (DDR); Rhodalline
Percent Composition: C 41.35%, H 6.94%, N 24.11%, S 27.60%
Literature References: Made by warming a mixture of equal parts of allyl mustard oil and abs alcohol with an equal amount of 30% ammonia. Growth regulating activity: Karanov, Vasilev, Izv. Inst. Fiziol. Rast. Bulg. Akad. Nauk 16, 167 (1970), C.A. 73, 119454y (1970). Mechanism of action studies as an egg suppressive agent in schistosomiasis, A. B. Machado et al., J. Parasitol. 56, 392 (1970). In vivo and in vitro effects: I. Popiel, D. A. Erasmus, Trans. R. Soc. Trop. Med. Hyg. 75, 287 (1981). Toxicity study: S. H. Dieke et al., J. Pharmacol. Exp. Ther. 90, 260 (1947).

Acetal CAS Registry Number: 105-57-7 1,1-二乙氧基乙烷

CAS Name: 1,1-Diethoxyethane
Additional Names: diethylacetal; acetaldehyde diethyl acetal; ethylidene diethyl ether
Percent Composition: C 60.98%, H 11.94%, O 27.08%
Literature References: Made from acetaldehyde and alcohol in the presence of anhydrous calcium chloride or of small quantities of mineral acid: H. Adkins, B. H. Nissen, J. Am. Chem. Soc. 44, 2750 (1922); eidem, Org. Synth. coll. vol. I, 1 (2nd ed., 1941). Toxicity study: H. F. Smyth et al., J. Ind. Hyg. Toxicol. 31, 60 (1949).

Andrographolide CAS Registry Number: 5508-58-7 穿心莲内酯

CAS Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Additional Names: 3a,14,15,...
Literature References: Main bitter constituent and medicinally active principle isolated from the leaves of andrographis, q.v. Isoln: M. K. Gorter, Rec. Trav. Chim. 30, 151 (1911). Rapid isoln method: M. Rajani et al., Pharmaceut. Biol. 38, 204 (2000). Characterization: D. Chakravarti, R. N. Chakravarti, J. Chem. Soc. 1952, 1697; R. Schwyzer et al., Helv. Chim. Acta 34, 652 (1951). Structure: M. P. Cava, B. Weinstein, Chem. Ind. (London) 1959, 851. Revised structure: M. P. Cava et al., ibid. 1963, 167; M. P. Cava et al., Tetrahedron 21, 2617 (1965). X-ray crystallographic analysis: T. Fujita et al., Chem. Pharm. Bull. 32, 2117 (1984). HPLC determn in plant material: A. Sharma et al., Phytochem. Anal. 3, 129 (1992). Determn in Chinese medicinal prepns: Z. Yanfang et al., J. Pharm. Biomed. Anal. 40, 157 (2006). Mechanism of anti-inflammatory action: Y.-F. Xia et al., J. Immunol. 173, 4207 (2004). Clinical pharmacokinetics and bioavailability from herbal preparations: A. Panossian et al., Phytomedicine 7, 351 (2000).

Narasin CAS Registry Number: 55134-13-9 甲基盐霉素

CAS Name: (4S)-4-Methylsalinomycin
Additional Names: narasin ATrademarks: Monteban (Elanco)
Percent Composition: C 67.51%, H 9.49%, O 23.00%
Literature References: Main component of a polyether antibiotic complex produced by Streptomyces aureofaciens NRRL 5758 NRRL 8092. Production: D. H. Berg et al., DE 2525095 corresp to US 4038384 (1975, 1977 to Lilly); L. D. Boeck et al., Dev. Ind. Microbiol. 18, 471 (1976). Isoln and characterization: D. H. Berg, R. L. Hamill, J. Antibiot. 31, 1 (1978). Biosynthetic studies using 13C-NMR study: D. E. Dorman et al., Helv. Chim. Acta 59, 2625 (1976). Structure: J. L. Occolowitz et al., Biomed. Mass Spectrom. 3, 272 (1976); H. Seto et al., J. Antibiot. 30, 530 (1977). Anticoccidial activity: M. D. Ruff et al., Poult. Sci. 59, 2008 (1980). Total synthesis: Y. Kishi et al., Front. Chem., Plenary Keynote Lect. IUPAC Congr., 28th 1981, K. J. Laidler, Ed. (Pergamon, Oxford, 1982) pp 287-304. HPLC determn in animal feeds: M. R. LaPointe, H. Cohen, J. Assoc. Off. Anal. Chem. 71, 480 (1988).

Candidin CAS Registry Number: 1405-90-9 制假丝菌素

Percent Composition: C 61.22%, H 7.76%, N 1.52%, O 29.50%
Literature References: Main component of an antifungal antibiotic complex produced by the soil actinomycete Streptomyces viridoflavus: W. A. Taber et al., Antibiot. Chemother. 4, 455 (1954); L. C. Vining et al., Antibiot. Annu. 2, 980 (1954-1955); L. C. Vining, W. A. Taber, Can. J. Chem. 34, 1163 (1956). The two other active principles are designated as candidinin and candidoin. Prepn of pure crystalline candidin: Preud'hamme, Vuillemin, FR 1298345 (1962 to Rhone-Poulenc), C.A. 58, 420c (1963). Synthesis: M. Subramanian et al., J. Nat. Prod. 55, 1213 (1992). Structure: Borowski et al., Tetrahedron Lett. 1971, 1987; and NMR characterization: J. Pawlak et al., J. Antibiot. 46, 1598 (1993). Antifungal activity studies: Solotorovsky et al., Antibiot. Chemother. 8, 364 (1958).

Convallamarogenin CAS Registry Number: 16683-27-5 5beta-螺甾-25(27)-烯-1beta,3beta-二醇

Percent Composition: C 75.31%, H 9.83%, O 14.86%
Literature References: Main genin of the glycoside, convallamarin. From root of Convallaria majalis L., Liliaceae. Isoln and structure: Tschesche et al., Ber. 94, 1699 (1961). From Reineckia carnea Kunth., Liliaceae: Takeda et al., Tetrahedron 19, 759 (1963).

Buphanitine CAS Registry Number: 4673-18-1 (N,N-二乙基-4-亚硝基苯胺HYDROCHLOR＆)

CAS Name: (1a,3a)-7-Methoxycrinan-1,3-diol
Additional Names: hemanthine; nerbowdine
Percent Composition: C 63.94%, H 6.63%, N 4.39%, O 25.05%
Literature References: Major alkaloid from Buphane (Boöphane) disticha Herb., Appleg. (Haemanthus toxicarius Herb.), Amaryllidaceae. Isoln: Lewin, Arch. Exp. Pathol. Pharmakol. 68, 333 (1912); Tutin, ibid. 69, 314 (1912). Identity with hemanthine: Goosen, Warren, Chem. Ind. 1957, 267; with nerbowdine: Lyle et al., J. Am. Chem. Soc. 82, 2620 (1960). Structure studies: Goosen, Warren, J. Chem. Soc. 1960, 1097; Goosen et al., ibid. 1961, 4038. High-resolution mass spectrum: P. Longevialle et al., Org. Mass Spectrom. 7, 401 (1973).