其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Pseudopelletierine CAS Registry Number: 552-70-5 9-甲基-9-氮杂双环[3.3.1]壬-3-酮

CAS Name: 9-Methyl-9-azabicyclo[3.3.1]nonan-3-one
Additional Names: 9-methyl-3-granatanone; pseudopunicine
Percent Composition: C 70.55%, H 9.87%, N 9.14%, O 10.44%
Literature References: In root bark of Punica granatum L., Punicaceae. Extraction procedure: Hess, Eichel, Ber. 50, 380, 1391, 1395 (1917); ibid. 52, 1012 (1919). Synthesis under physiological conditions from calcium acetonedicarboxylate, glutardialdehyde, and methylamine: Menzies, Robinson, J. Chem. Soc. 1924, 2163; cf. Schöpf, Angew. Chem. 50, 779, 797 (1937). Alternate syntheses: Cope et al., Org. Synth. 37, 73 (1957); Robinson, Hunt, J. Pharm. Pharmacol. 22, 29S (1970); Bottini, Gal, J. Org. Chem. 36, 1718 (1971). Conformation: Chen, LeFevre, J. Chem. Soc. B 1966, 539.

Salsoline CAS Registry Number: 101467-40-7 叉明草素

CAS Name: (R)-1,2,3,4-Tetrahydro-7-methoxy-1-methyl-6-isoquinolinol
Additional Names: 6-hydroxy-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; (+)-salsoline
Percent Composition: C 68.37%...
Literature References: In Salsola richteri Karel., Chenopodiaceae. Extraction procedure: A. Orechoff, N. Proskurnina, Ber. 66, 841 (1933); N. Proskurnina, A. Orekhoff, Bull. Soc. Chim. Fr. 1937, 1265. Structure and synthesis: E. Späth et al., Ber. 67, 1214 (1934); O. Kovács, G. Fodor, Ber. 84, 795 (1951). Abs config: A. R. Battersby, T. P. Edwards, J. Chem. Soc. 1960, 1214. Biosynthetic studies: I. McFarlane, M. Slaytor, Phytochemistry 11, 235 (1972). Synthesis of enantiomers: S. Teitel et al., J. Med. Chem. 17, 134 (1974). HPLC study: J. Strömbom, J. G. Bruhn, J. Chromatogr. 147, 513 (1978).

Trigonelline CAS Registry Number: 535-83-1 葫芦巴碱

CAS Name: 3-Carboxy-1-methylpyridinium inner salt
Additional Names: nicotinic acid N-methylbetaine; coffearine; caffearine; gynesine; trigenolline
Percent Composition: C 61.31%, H 5.14%, N 1...
Literature References: In seeds of Trigonella foenumgraecum L., Leguminosae, in coffee beans, in seeds of Strophanthus spp, Apocynaceae and of Cannabis sativa L., Moraceae, in seeds of many other plants; also in sea urchin, Arabacia pustulosa, and in jellyfish, Velella spirans. Excreted in urine after taking nicotinic acid: Ackermann, Z. Biol. 59, 17 (1912). Isoln from normal urine: Linnewah, Renwein, Z. Physiol. Chem. 207, 48 (1932); 209, 110 (1932). Syntheses: Turnau, Monatsh. Chem. 26, 551 (1905); Sarett et al., J. Biol. Chem. 135, 483 (1940); Green, Tong, J. Am. Chem. Soc. 78, 4896 (1956); Kosower, Patton, J. Org. Chem. 26, 1318 (1961). Toxicity study: Brazda, Coulson, Proc. Soc. Exp. Biol. Med. 62, 19 (1946).

Vicianin CAS Registry Number: 155-57-7 蠶豆氰苷

Additional Names: Mandelonitrile vicianoside
Percent Composition: C 53.39%, H 5.90%, N 3.28%, O 37.43%
Literature References: In seeds of Vicia angustifolia Clos, and V. sativa L., Leguminosae. Isoln: Bertrand, Compt. Rend. 143, 832 (1906); Bull. Soc. Chim. [4] 1, 151 (1907); Bertrand, Weisweiller, Compt. Rend. 147, 252 (1908); 151, 325 (1910); Bull. Soc. Chim. [4] 9, 147 (1911). Preparation of hexaacetyl-b-vicianoside of (-)-mandelonitrile, believed to be vicianin hexaacetate: Chaudhury, Robertson, J. Chem. Soc. 1949, 2054.

Tsuduranine CAS Registry Number: 517-97-5 土杜拉寧

CAS Name: (6aR)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-4H-dibenzo[de,g]quinolin-10-ol
Additional Names: 1,2-dimethoxy-6ab-noraporphin-10-ol; tuduranine
Percent Composition: C 72.71%, H 6.44%, N 4...
Literature References: In sinomenine mother liquors. Isoln: Gotô, Ann. 521, 175 (1935). Structure: Gotô, Shishido, Ann. 539, 262 (1939). Synthesis of dl-form: Narayanaswami et al., Indian J. Chem. 7, 945 (1969).

Betulin CAS Registry Number: 473-98-3 白桦脂醇; 桦木醇

CAS Name: (3b)-Lup-20(29)-ene-3,28-diol
Additional Names: lup-20(30)-ene-3b,28-diol; trochol; betulinol; betulol
Percent Composition: C 81.39%, H 11.38%, O 7.23%
Literature References: In the outer portion of the bark of white birch (up to 24%), in other barks, and in lignite. Isoln: Lowitz, Crell's Chem. Ann. 1, 312 (1788); L. Ruzicka, O. Isler, Helv. Chim. Acta 19, 506 (1936); and botanical distribution: Steiner, Molisch Festschrift (1936). Isoln from Lemaireocereus griseus Britton et Rose, Cactaceae: C. Djerassi et al., J. Am. Chem. Soc. 78, 2312 (1956). Structure: Ames et al., J. Chem. Soc. 1951, 450; Davy et al., ibid. 1951, 2696, 2702. Stereochemistry: Guider et al., ibid. 1953, 3024; Das, Chem. Ind. (London) 1971, 1331. Reviews: J. Simonsen, W. C. J. Ross, The Terpenes vol. IV (Cambridge Univ. Press, 1957) pp 187-328; E. W. H. Hayek et al., Phytochemistry 28, 2229-2242 (1989).

Sparteine CAS Registry Number: 90-39-1 鹰爪豆碱

CAS Name: [7S-(7a,7aa,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine
Additional Names: l-sparteine; lupinidine
Percent Composition: C 76.87%, H 11.18%, N 11....
Literature References: In yellow and black lupin beans, Lupinus luteus L. and L. niger Hort.; also in Cytisus scoparius (L.) Link. and Anagyris foetida L., Leguminosae. Extraction procedure: Karrer et al., Helv. Chim. Acta 11, 1062 (1928). Structure: Clemo et al., J. Chem. Soc. 1931, 429; Ing, ibid. 1933, 504; Schirm, Besendorf, Arch. Pharm. 280, 64 (1942); Galinovsky, Stern, Ber. 77B, 132 (1944); Clemo et al., J. Chem. Soc. 1949, 663. Biosynthesis: Anet et al., Nature 165, 35 (1950); Schöpf et al., Angew. Chem. 65, 161 (1953); 69, 69 (1957); van Tamelen, Foltz, J. Am. Chem. Soc. 82, 2400 (1960). Absolute configuration: Okuda et al., Chem. Ind. (London) 1961, 1116. Conformation: Bohlmann et al., Tetrahedron Lett. 1965, 2705; Wiewiorowski et al., Can. J. Chem. 45, 1447 (1967). Synthesis of racemate: Bohlmann et al., Ber. 106, 3026 (1973); N. Takatsu et al., Chem. Pharm. Bull. 35 4990 (1987). Chemistry: Binnig, Arzneim.-Forsch. 24, 752 (1974). Studies of cardiovascular effects: Raschak, ibid. 753.

Potassium Binoxalate CAS Registry Number: 127-95-7 草酸氢钾

Additional Names: Potassium acid oxalate; salt of sorrel; sal acetosella
Percent Composition: C 18.75%, H 0.79%, K 30.51%, O 49.95%
Literature References: Incorrectly salt of lemon. The same synonyms apply to potassium tetraoxalate.

Potassium Tetroxalate CAS Registry Number: 127-96-8 乙二酸钾盐

Additional Names: Potassium quadroxalate; sal acetosella; salt of sorrel
Percent Composition: C 22.02%, H 1.39%, K 17.92%, O 58.67%
Literature References: Incorrectly called essential salt of lemons.

Sulfacetamide CAS Registry Number: 144-80-9 磺胺醋酰

CAS Name: N-[(4-Aminophenyl)sulfonyl]acetamide
Additional Names: N-sulfanilylacetamide; N1-acetylsulfanilamide; p-aminobenzenesulfonoacetamide
Percent Composition: C 44.85%, H 4.70%, N 13.08...
Literature References: Incorrectly called sulfacetimide. Prepn: M. L. Crossley et al., J. Am. Chem. Soc. 61, 2950 (1939); M. Dohrn, P. Diedrich, Muench. Med. Wochenschr. 85, 2017 (1938); eidem, US 2411495 (1946 to Schering). Toxicity: R. S. Fisher, H. B. Haag, J. Urol. 47, 183 (1942). Antimicrobial activity: R. D. Houlsby et al., J. Pharm. Sci. 72, 1401 (1983). GC determn in animal tissues: A. E. Mooser, H. Koch, J. AOAC Int. 76, 976 (1993). Clinical trial in conjunctivitis: J. A. Lohr et al., Pediatr. Infect. Dis. J. 7, 626 (1988); in acne: D. L. Breneman, M. C. Ariano, Int. J. Dermatol. 32, 365 (1993). Comprehensive description: I. Ahmad et al., Anal. Profiles Drug Subs. Excip. 23, 471-509 (1994).