其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pseudoconhydrine CAS Registry Number: 140-55-6 (3S,6S)-6-丙基哌啶-3-醇

CAS Name: (3S-trans)-6-Propyl-3-piperidinol
Additional Names: 5-hydroxy-2-propylpiperidine; 5-hydroxyconiine
Percent Composition: C 67.08%, H 11.96%, N 9.78%, O 11.17%
Literature References: In Conium maculatum L., Umbelliferae (hemlock). Extraction procedure: Ladenburg et al., Ber. 24, 1671 (1891); Braun, Ber. 38, 3108 (1905); Löffler, Ber. 42, 116 (1909). Structure: E. Späth et al., Ber. 66, 591 (1933). Stereochemistry: R. K. Hill, J. Am. Chem. Soc. 80, 1611 (1958); K. Tadano et al., J. Carbohydr. Chem. 4, 129 (1985).

Corypalmine CAS Registry Number: 6018-40-2 延胡索单酚碱

CAS Name: 5,8,13,13a-Tetrahydro-2,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-3-ol
Additional Names: 2,9,10-trimethoxyberbin-3-ol; 3-hydroxy-2,9,10-trimethoxyberbine; tetrahydrojatrorrhizine
P...
Literature References: In Corydalis cava (L.) Schweigg Körte (C. tuberosa D.C.) and other varieties of Corydalis, Fumariaceae. Synthesis of dl-corypalmine: Govindachari et al., Ber. 92, 1654 (1959).

Corytuberine CAS Registry Number: 517-56-6 紫堇块茎碱

CAS Name: (6aS)-5,6,6a,7-Tetrahydro-2,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-1,11-diol
Additional Names: 2,10-dimethoxy-6aa-aporphine-1,11-diol; 1,11-dihydroxy-2,10-dimethoxyaporphine<...
Literature References: In Corydalis cava (L.) Schweigg Körte (C. tuberosa DC), in Dicentra formosa (Andr.) Walp., Fumariaceae. Isoln: Späth, Berger, Ber. 64, 2038 (1931); Manske, Can. J. Res. 10, 521 (1934). Synthesis of (±)-form: Tomita, Kikkawa, JP 58 6466 (1958 to Shionogi), C.A. 54, 1584i (1960); T. Kametani, M. Ihara, J. Chem. Soc. Perkin Trans. 1 1980, 629. Biosynthesis studies: Blaschke, Biochem. Physiol. Alkaloide, Int. Symp., 4th, K. Mothes, Ed. (Akad.-Verlag, Berlin, 1972) pp 283-286. Biomimetric total synthesis: T. Kametani et al., Heterocycles 5, 175 (1976).

Corycavamine CAS Registry Number: 521-85-7 紫堇文碱

CAS Name: (14R)-4,6,7,14-Tetrahydro-5,14-dimethylbis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one
Additional Names: 7,13-dimethyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one
Pe...
Literature References: In Corydalis cava (L.) Schweigg Korte (C. tuberosa DC.), Fumariaceae: Gadamer et al., Arch. Pharm. 240, 81 (1902). Structure: von Bruchhausen, ibid. 263, 570 (1925). Corycavamine and corycavine originally depicted as the keto and enol tautomers, resp.

Corybulbine CAS Registry Number: 518-77-4 紫堇鳞茎碱

CAS Name: 5,8,13,13a-Tetrahydro-2,9,10-trimethoxy-13-methyl-6H-dibenzo[a,g]quinolizin-3-ol
Additional Names: 2,9,10-trimethoxy-13-methyl-13a-berbin-3-ol; 3-hydroxy-13-methyl-2,9,10-trimethoxybe...
Literature References: In Corydalis cava (L.) Schweigg Korte (C. tuberosa DC.); Fumariaceae: Freund, Josephi, Ann. 277, 1 (1893); in C. platycarpa Makino, Fumariaceae: Manske, Can. J. Res. 21B, 13 (1943). Structure: Späth, Dobrowsky, Ber. 58, 1274 (1925).

Norlobelanine CAS Registry Number: 6035-31-0 2,2'-(2,6-哌啶二基)二(1-苯乙酮)

CAS Name: 2,2'-(2,6-Piperidinediyl)bis[1-phenylethanone]
Additional Names: isolobelanine
Percent Composition: C 78.47%, H 7.21%, N 4.36%, O 9.96%
Literature References: In herb of Lobelia inflata L., Lobeliaceae. Isoln from crude lobelanidine nitrate: Wieland et al., Ann. 473, 118 (1929). Synthesis: Schöpf, Lehmann, ibid. 518, 1 (1935). Cis- and trans-isomers: Ebnöther, Helv. Chim. Acta 41, 386 (1958).

Esculin CAS Registry Number: 531-75-9 秦皮甲素

CAS Name: 6-(b-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
Additional Names: 6,7-dihydroxycoumarin 6-glucoside; esculoside; bicolorin; enallachrome; polychrome
Trademarks: Escosyl Literature References: In leaves and bark of horse chestnut tree Aesculus hippocastanum L., Hippocastanaceae. Extraction procedure: Tumann, Chem. Zentralbl. 1916, I, 1277. Synthesis: Merz, Hagemann, Naturwissenschaften 29, 650 (1941); eidem, Arch. Pharm. 282, 79 (1944); Amiard, Nominé, Bull. Soc. Chim. Fr. 1948, 476. Use in bile-esculin test for identification of group D streptococci: C. Chuard, L. B. Reller, J. Clin. Microbiol. 36, 1135 (1998).

N-Methylpyrroline CAS Registry Number: 554-15-4 2,5-二氢-1-甲基-1H-吡咯

CAS Name: N-Methyl-2,5-dihydropyrrole
Percent Composition: C 72.24%, H 10.91%, N 16.85%
Literature References: In leaves of Nicotiana tabacum L. and Atropa belladonna L. By reducing N-methylpyrrole with zinc granules in dil acetic or hydrochloric acid.

Lophophorine CAS Registry Number: 17627-78-0 (9S)-6,7,8,9-四氢-4-甲氧基-8,9-二甲基-1,3-二氧杂环戊并[4,5-h]异喹啉

CAS Name: (9S)-6,7,8,9-Tetrahydro-4-methoxy-8,9-dimethyl-1,3-dioxolo[4,5-h]isoquinoline
Additional Names: N-methylanhalonine
Percent Composition: C 66.36%, H 7.28%, N 5.95%, O 20.40%
Literature References: In Lophophora williamsii (Lemaire) Coult., Cactaceae. Extraction procedure: Kauder, Arch. Pharm. 237, 191 (1899). Structure: Späth, Gangl, Monatsh. Chem. 44, 104, 106 (1923). Synthesis: Späth, Kesztler, Ber. 68, 1667 (1935).

Domesticine CAS Registry Number: 476-71-1

CAS Name: (6aS)-5,6,6a,7-Tetrahydro-2-methoxy-6-methyl-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinolin-1-ol
Additional Names: 2-methoxy-9,10-(methylenedioxy)-6aa-aporphin-1-ol; 1-hydroxy-2-methoxy...
Literature References: In Nandina domestica Thunb., Berberidaceae. Isoln: Kitasato, Shishido, Ann. 527, 176 (1937). Syntheses: Govindachari et al., Indian J. Chem. 7, 841 (1969); Kessar et al., ibid. 8, 468 (1970); Kametani et al., J. Chem. Soc. C 1971, 2446, 2712; eidem, Chem. Pharm. Bull. 21, 766 (1973); Horii et al., ibid. 22, 583 (1974); Hoshino et al., ibid. 23, 2048 (1975).