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临床前CDMO研发化合物筛选
Ampicillin Trihydrate
中文名称:氨苄青霉素,三水
CAS号:7177-48-2
分子式: C16H19N3O4S.3H2O 分子量: 403.45
产品形式: free base
研发状态: Recruiting
研发用途: Infective Endocarditis
研究机构: Uppsala University
研发日期: June 1 2021
研发阶段: --
Ampicillin Trihydrate (NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Amisulpride
中文名称:阿米舒必利
CAS号:71675-85-9
分子式: C17H27N3O4S 分子量: 369.48
产品形式: free base
研发状态: Completed
研发用途: Renal Disease End Stage
研究机构: Acacia Pharma Ltd
研发日期: June 3 2021
研发阶段: Phase 1
Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
Medroxyprogesterone acetate (NSC-26386)
中文名称:安宫黄体酮
CAS号:71-58-9
分子式: C24H34O4 分子量: 386.52
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Inflammation; Periodontal Diseases
研究机构: University College London
研发日期: September 1 2024
研发阶段: Not Applicable
Medroxyprogesterone acetate (MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.
AC480 (BMS-599626)
CAS号:714971-09-2
分子式: C27H27FN8O3 分子量: 530.55
产品形式: free base
研发状态: Withdrawn
研发用途: Solid Tumors
研究机构: Daiichi Sankyo
研发日期: Nov-10
研发阶段: Phase 1
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
Spermine
中文名称:精胺
CAS号:71-44-3
分子式: C10H26N4 分子量: 202.34
产品形式: free base
研发状态: Withdrawn
研发用途: Prostate Cancer
研究机构: Chinese University of Hong Kong
研发日期: September 1 2021
研发阶段: --
Spermine (4,9-Diaza-1,12-dodecanediamine) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.
Plinabulin (NPI-2358)
中文名称: (3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮
CAS号:714272-27-2
分子式: C19H20N4O2 分子量: 336.39
产品形式: free base
研发状态: Terminated
研发用途: ALK Gene Translocation; EGFR Activating Mutation; Recurrent Non-Small Cell Lung Carcinoma; ROS1 Gene Translocation; Stage IIIB Non-Small Cell Lung Cancer AJCC v7; Stage IV Non-Small Cell Lung Cancer AJCC v7
研究机构: University of Washington; National Cancer Institute (NCI)
研发日期: June 14 2017
研发阶段: Phase 1 : Phase 2
Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
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