临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
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临床前CDMO研发化合物筛选

CAS: 73590-58-6

Omeprazole

中文名称:奥美拉唑
CAS号:73590-58-6
分子式: C17H19N3O3S 分子量: 345.42
产品形式: free base
研发状态: Not yet recruiting
研发用途: Colorectal Neoplasia
研究机构: University of Michigan Rogel Cancer Center; National Cancer Institute (NCI)
研发日期: May-24
研发阶段: Early Phase 1
Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.

CAS: 73334-07-3

Iopromide

中文名称:碘普罗胺
CAS号:73334-07-3
分子式: C18H24I3N3O8 分子量: 791.11
产品形式: free base
研发状态: Not yet recruiting
研发用途: Pancreatitis Chronic
研究机构: Peking University People''s Hospital
研发日期: April 1 2023
研发阶段: --
Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs.

CAS: 73-32-5

isoleucine

中文名称:L-异亮氨酸
CAS号:73-32-5
分子式: C6H13NO2 分子量: 131.17
产品形式: free base
研发状态: Not yet recruiting
研发用途: Perinatal Solid Tumors of the Thoraco-abdomino-pelvic Region
研究机构: Assistance Publique - Hôpitaux de Paris
研发日期: May-24
研发阶段: --
Isoleucine (Ile) is a non-polar, uncharged (at physiological pH), aliphatic amino acid that is used in the biosynthesis of proteins.

CAS: 73-31-4

Melatonin (NSC 113928)

中文名称:褪黑素
CAS号:73-31-4
分子式: C13H16N2O2 分子量: 232.28
产品形式: free base
研发状态: Not yet recruiting
研发用途: Pregnancy Related; Labor; Poor; Uterine Contractions Weak
研究机构: Michigan State University; McLaren Health Care
研发日期: October 1 2024
研发阶段: Not Applicable
Melatonin (NSC 113928, NSC 56423, N-Acetyl-5-methoxytryptamine,MT) is a MT receptor agonist, used as a dietary supplement. Melatonin is a selective ATF-6 inhibitor and downregulates COX-2. Melatonin enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.

CAS: 733030-01-8

TAS-102

中文名称:三氟苷/替吡哧盐酸盐混合物
CAS号:733030-01-8
分子式: C10H11F3N2O5.0.5C9H11ClN4O2.0.5HCl 分子量: 435.76
产品形式: hydrochloride
研发状态: Not yet recruiting
研发用途: Metastatic Colorectal Cancer
研究机构: Holy Stone Healthcare Co. Ltd
研发日期: Jan-24
研发阶段: Phase 2
TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.

CAS: 732302-99-7

Givinostat (ITF2357)

CAS号:732302-99-7
分子式: C24H27N3O4.HCl.H2O 分子量: 475.97
产品形式: Chloride
研发状态: Recruiting
研发用途: Duchenne Muscular Dystrophy
研究机构: Italfarmaco
研发日期: February 19 2024
研发阶段: Phase 3
Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM in cell-free assays. Phase 2.