CAS: 73334-07-3; N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-5-(2-Methoxyacetamido)-N1-Methylisophthalamide

上下游产品

3-methylamino-propane-1,2-diol pyrographite 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide 5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

四-O-乙酰基碘普胺置于sodium Hydroxide,盐酸体系中,化学反应 4.0H,以99%的收率获得产物碘普罗胺
参考文献:一种碘普罗胺中间体的制备方法及其用途
标题:一种碘普罗胺中间体的制备方法及其用途
摘要:本发明涉及一种碘普罗胺中间体的制备方法,及其用于制备碘普罗胺的用途.所述方法包括:式vi化合物在雷尼镍/水合肼的作用下发生还原反应得到式v化合物.该反应在常压下进行,操作简单安全,且反应生成的中间体杂质较少,更适用于工业化生产.将该方法用于制备碘普罗胺,可避免二酰化副产物的反应生成,而且在制备过程中可以有效减少副产物的反应生成,中间体易于分离纯化,能够以高收率获得高纯度的碘普罗胺.

专利信息

专利号:US-2015359913-A1
优先权日:2013-01-25
标题:Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides
发明人：REINER THOMAS; LEWIS JASON STUART; WEISSLEDER RALPH; ZEGLIS BRIAN
权利人:SLOAN KETTERING INST CANCER; GEN HOSPITAL CORP
摘要:This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-12269790-B1
优先权日:2022-04-29
标题:Process for the preparation of 2,4,6-triiodophenol derivatives
发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
权利人:BRACCO IMAGING SPA
摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.

专利号:US-9238615-B2
优先权日:2009-04-21
标 题 :Process for the iodination of aromatic compounds
发明人：CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA
权利人:CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.