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临床前CDMO研发化合物筛选
Vinorelbine ditartrate (KW-2307)
中文名称:酒石酸长春瑞滨
CAS号:125317-39-7
分子式: C45H54N4O8.2C4H6O6 分子量: 1079.11
产品形式: ditartrate
研发状态: Withdrawn
研发用途: Breast Cancer Stage IV
研究机构: Providence Health & Services; Seagen Inc.
研发日期: December 15 2021
研发阶段: Phase 1 : Phase 2
Vinorelbine Tartrate (KW-2307, Nor-5'-anhydrovinblastine ditartrate) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Triamcinolone
中文名称:曲安西龙
CAS号:124-94-7
分子式: C21H27FO6 分子量: 394.43
产品形式: free base
研发状态: Not yet recruiting
研发用途: Alopecia Areata
研究机构: Al-Azhar University
研发日期: Dec-23
研发阶段: Not Applicable
Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.
Valaciclovir HCl
中文名称:盐酸伐昔洛韦
CAS号:124832-27-5
分子式: C13H20N6O4.HCl 分子量: 360.80
产品形式: Hydrochloride
研发状态: Completed
研发用途: Varicella
研究机构: GlaxoSmithKline
研发日期: Mar-05
研发阶段: Phase 3
Valaciclovir HCl, an aciclovir prodrug, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV).
Losartan Potassium (DuP 753)
中文名称:氯沙坦钾
CAS号:124750-99-8
分子式: C22H23ClKN6O 分子量: 462.01
产品形式: Potassium salt
研发状态: Withdrawn
研发用途: Dyspnea; Lung Cancer; Pulmonary Complications; Radiation Fibrosis
研究机构: University of South Florida; National Cancer Institute (NCI)
研发日期: Mar-09
研发阶段: Not Applicable
Losartan Potassium (DuP 753, MK 954) is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
Losartan Carboxylic Acid (EXP-3174)
中文名称:氯沙坦
CAS号:124750-92-1
分子式: C22H21ClN6O2 分子量: 436.89
产品形式: Free Base
研发状态: Unknown status
研发用途: Healthy
研究机构: Hanmi Pharmaceutical Company Limited
研发日期: June 8 2022
研发阶段: Phase 1
Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.
VS-5584 (SB2343)
中文名称:5-[8-甲基-9-异丙基-2-(4-吗啉基)-9H-嘌呤-6-基]-2-嘧啶胺
CAS号:1246560-33-7
分子式: C17H22N8O 分子量: 354.41
产品形式: free base
研发状态: Terminated
研发用途: Relapsed Malignant Mesothelioma
研究机构: Verastem Inc.
研发日期: Jan-15
研发阶段: Phase 1
VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1.
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