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临床前CDMO研发化合物筛选
Phorbol 12-myristate 13-acetate (PMA)
中文名称:12-O-十四烷酰佛波醋酸酯-13
CAS号:16561-29-8
分子式: C36H56O8 分子量: 616.83
产品形式: Free base
研发状态: Recruiting
研发用途: Apnea of Prematurity
研究机构: University of California Irvine
研发日期: February 22 2024
研发阶段: Phase 2
Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.
Orelabrutinib (ICP-022)
中文名称:奥布替尼
CAS号:1655504-04-3
分子式: C26H25N3O3 分子量: 427.49
产品形式: free base
研发状态: Recruiting
研发用途: CLL/SLL
研究机构: Peking University People''s Hospital
研发日期: January 1 2022
研发阶段: Phase 2
Orelabrutinib (ICP-022) is a potent, orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). Orelabrutinib has potential antineoplastic activity.
GLPG1837
CAS号:1654725-02-6
分子式: C16H20N4O3S 分子量: 348.42
产品形式: free base
研发状态: Completed
研发用途: Cystic Fibrosis
研究机构: Galapagos NV
研发日期: Jan-16
研发阶段: Phase 2
GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.
SX-682
CAS号:1648843-04-2
分子式: C19H14BF4N3O4S 分子量: 467.20
产品形式: Free Base
研发状态: Recruiting
研发用途: Myelodysplastic Syndromes
研究机构: Syntrix Biosystems Inc.; H. Lee Moffitt Cancer Center and Research Institute; National Heart Lung and Blood Institute (NHLBI); Johns Hopkins University; AdventHealth; Emory University; University of Miami; Mayo Clinic
研发日期: May 12 2020
研发阶段: Phase 1
SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.
ONO-7475
中文名称:N-[5-[(6,7-二甲氧基-4-喹啉基)氧基]-2-吡啶基]-1,2,5,6,7,8-六羟基-2,5-二氧代-1-苯基-3-喹啉甲酰胺
CAS号:1646839-59-9
分子式: C32H26N4O6 分子量: 562.57
产品形式: Free Base
研发状态: Terminated
研发用途: Acute Leukemia; Myelodysplastic Syndromes
研究机构: Ono Pharmaceutical Co. Ltd
研发日期: June 26 2017
研发阶段: Phase 1 : Phase 2
ONO-7475 is a potent, selective, and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.
Dutasteride
中文名称:度他雄胺
CAS号:164656-23-9
分子式: C27H30F6N2O2 分子量: 528.53
产品形式: free base
研发状态: Withdrawn
研发用途: Prostatic Hyperplasia Benign; Metabolic Syndrome
研究机构: Complexo Hospitalario Universitario de A Coruña
研发日期: July 10 2018
研发阶段: Not Applicable
Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
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