CAS: 1654725-02-6; N-(3-Carbamoyl-5,5,7,7-Tetramethyl-5,7-Dihydro-4H-Thieno[2,3-C]Pyran-2-yl)-1H-Pyrazole-3-Carboxamide

主要参考文献

1: Van der Plas SE, Kelgtermans H, De Munck T, Martina SLX, Dropsit S, Quinton E, De Blieck A, Joannesse C, Tomaskovic L, Jans M, Christophe T, van der Aar E, Borgonovi M, Nelles L, Gees M, Stouten P, Van Der Schueren J, Mammoliti O, Conrath K, Andrews M. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyr azole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61(4):1425-1435. doi: 10.1021/acs.jmedchem.7b01288. Epub 2018 Jan 10. doi: 10.1016/j.jcf.2018.05.011. Epub 2018 Jun 7. doi: 10.3389/fphar.2018.01221. eCollection 2018.

合成参考文献

参考文献:10.1165/rcmb.2019-0291oc
摘要:Mutyam V, Sharma J, Li Y, Peng N, Chen J, Tang LP, Falk Libby E, Singh AK, Conrath K, Rowe SM. Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations. Am J Respir Cell Mol Biol. 2021 May;64(5):604–16.