临床前CDMO研发筛选相关化合物

CDMO是Contract Development and Manufacturing Organization的缩写，即合同定制研发生产组织。它是一种为制药企业及生物技术公司提供医药（特别是创新药）工艺研发及制备、工艺优化、放大生产、注册和验证批生产以及商业化生产等定制服务的机构. 在传统代工基础上增加了研发和工艺优化能力，是高技术壁垒的工艺研发能力与规模生产能力的深度结合. 1, 工艺开发与优化：创新性合成路线设计、工艺参数优化. 2, 中试放大：实验室工艺向规模化生产的转化 3, 注册批生产：支持客户新药申报的验证批生产. 4, 商业化生产：药品上市后的大规模生产供应. 全球医药CDMO行业保持较高景气度。根据弗若斯特沙利文预测：2026年全球CDMO市场规模：预计达1,189亿美元 2033年全球CDMO市场规模：预计达3,385亿美元. CDMO作为医药产业链专业化分工的产物，已经从单纯的CMO代工模式升级为"研发+生产"一体化的高附加值服务。当前，在多肽、ADC、CGT等新型药物赛道的驱动下，全球及中国CDMO市场保持高速增长。中国CDMO企业凭借完整的供应链体系、工程师红利和一体化服务能力，全球市占率有望持续提升，行业正从"成本优势"竞争迈向"体系优势"竞争的新阶段。
如有产品调研服务, 请致函联系我们

客户展示

临床前CDMO研发化合物筛选

CAS: 247257-48-3

Fimasartan

中文名称: 非马沙坦
CAS号:247257-48-3
分子式: C27H31N7OS 分子量: 501.65
产品形式: free base
研发状态: Completed
研发用途: Hypertension Hyperlipidemia
研究机构: Boryung Pharmaceutical Co. Ltd
研发日期: December 23 2016
研发阶段: Phase 1
Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

CAS: 2468015-78-1

Lufotrelvir (PF-07304814)

CAS号:2468015-78-1
分子式: C24H33N4O9P 分子量: 552.51
产品形式: Free base
研发状态: Completed
研发用途: Healthy
研究机构: Pfizer
研发日期: October 7 2021
研发阶段: Phase 1
PF-07304814 is a phosphate prodrug of PF-00835231 that binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174 nM.

CAS: 2451-62-9

Triglycidyl Isocyanurate (Teroxirone)

中文名称:异氰尿酸三缩水甘油酯
CAS号:2451-62-9
分子式: C12H15N3O6 分子量: 297.26
产品形式: Free Base
研发状态: Recruiting
研发用途: Advanced or Metastatic Solid Tumors
研究机构: Hefei TG ImmunoPharma Co. Ltd.
研发日期: January 3 2024
研发阶段: Phase 1
Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

CAS: 244767-67-7

Dapivirine (TMC120)

中文名称:达匹韦林
CAS号:244767-67-7
分子式: C20H19N5 分子量: 329.40
产品形式: free base
研发状态: Active not recruiting
研发用途: HIV Infections
研究机构: International Partnership for Microbicides Inc.
研发日期: August 1 2022
研发阶段: Phase 1
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

CAS: 2447-57-6

Sulfadoxine

中文名称:磺胺多辛
CAS号:2447-57-6
分子式: C12H14N4O4S 分子量: 310.33
产品形式: free base
研发状态: Recruiting
研发用途: Maternal Malaria During Pregnancy - Baby Not Yet Delivered
研究机构: Groupe de Recherche Action en Sante; European Vaccine Initiative
研发日期: August 25 2023
研发阶段: --
Sulfadoxine (Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax.

CAS: 243984-11-4

Resatorvid (TAK-242)

中文名称:瑞沙托维
CAS号:243984-11-4
分子式: C15H17ClFNO4S 分子量: 361.82
产品形式: Free base
研发状态: Unknown status
研发用途: Acute-On-Chronic Liver Failure
研究机构: Akaza Bioscience Ltd; Iqvia Pty Ltd
研发日期: Dec-21
研发阶段: Phase 2
Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.