CAS: 2468015-78-1; (S)-3-((S)-2-(4-Methoxy-1H-Indole-2-Carboxamido)-4-Methylpentanamido)-2-Oxo-4-((S)-2-Oxopyrrolidin-3-yl)Butyl Dihydrogen Phosphate

主要参考文献

1: Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond J, Hoffman R, Kadar EP, Kania R, Kimoto E, Kirkpatrick MG, Lanyon L, Lendy EK, Lillis JR, Luthra SA, Ma C, Noell S, Obach RS, O'Brien MN, O'Connor R, Ogilvie K, Owen D, Pettersson M, Reese MR, Rogers T, Rossulek MI, Sathish JG, Steppan C, Ticehurst M, Updyke LW, Zhu Y, Wang J, Chatterjee AK, Mesecar AD, Anderson AS, Allerton C. Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19. bioRxiv [Preprint]. 2020 Sep
13:2020.09.12.293498. doi: 10.1101/2020.09.12.293498.

合成参考文献

参考文献:10.1055/s-0041-1737093
摘要:Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents. Synfacts. 2021 Nov 17;17(12):1311. doi: 10.1055/s-0041-1737093.
参考文献:10.1021/acs.jmedchem.0c01063
摘要:Hoffman RL, Kania RS, Brothers MA, Davies JF, Ferre RA, Gajiwala KS, He M, Hogan RJ, Kozminski K, Li LY, Lockner JW, Lou J, Marra MT, Mitchell LJ, Murray BW, Nieman JA, Noell S, Planken SP, Rowe T, Ryan K, Smith GJ, Solowiej JE, Steppan CM, Taggart B. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725–47. doi: 10.1021/acs.jmedchem.0c01063.