项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

CP-99994

(2S,3S)-N-[(2-甲氧基苯基)甲基]-2-苯基-3-哌啶胺Chemical Name: (+)-(2S,3S)-3-(2-Methoxybenzylamino)-2-phenylpiperidine
CAS No. 136982-36-0, 136983-42-1 (HCl), 139190-12-8 (mono (R)-alpha-hydroxybenzeneacetate sa...
参考文献标题:Stereoselective synthesis of (+)-CP-99,994: A substance P non-peptide antagonist
文献作者:Chandrasekhar,S.; Mohanty,P.K.
参考来源:Tetrahedron Lett 1999,40(27),5071

Selodenoson, RG-14202, DTI-0009

(2S,3S,4R,5R)-5-[6-(环戊基氨基)嘌呤-9-基]-N-乙基-3,4-二羟基四氢呋喃-2-甲酰胺Chemical Name: N6-Cyclopentyl-N5'-ethyladenosine-5'-uronamide
CAS No. 110299-05-3
项目整合开发状态: Phase II
项目研究机构: Aderis (Originator), Fujis...
参考文献标题:N-6 Substd.-5'-(N-substd.carboxamido)adenosines as cardiac vasodilators and antihypertensive agents
文献作者:Olsson,R.A.; Thompson,R.D.(UCB Pharma,Inc.)
参考来源:AU 8544972; EP 0191025; ES 8609359; JP 1986286398; US 5310731; WO 8600310

FK-888

(2S,4R)-4-羟基-1-(1-甲基吲哚-3-羰基)-N-[(2S)-1-(甲基-(苯基甲基)氨基)-3-萘-2-基-1-氧代丙烷-2-基]吡咯烷-2-甲酰胺Chemical Name: 1-Methylindol-3-ylcarbonyl-[4(R)-hydroxy]-L-prolyl-[3-(2-naphthyl)]-L-alanine N-benzyl-N-methylamide
...
参考文献标题:Peptides having tachykinin antagonist activity,a process for preparation thereof and pharmaceutical compsns.comprising the same
文献作者:Matsuo,M.; Hagiwara,D.; Miyake,H.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0443132; JP 1992210996; US 5468731

BILA-2185-BS

(2S,4R)-N-叔丁基-1-[(2R,3S)-3-[[2-(2,6-二甲基苯氧基)乙酰基]氨基]-2-羟基-4-苯基丁基]-4-吡啶-4-基硫基哌啶-2-甲酰胺Chemical Name: N-tert-Butyl-1-[3(S)-[2-(2,6-dimethylphenoxy)acetamido]-2(R)-hydroxy-4-phenylbutyl]-4(R)-(4-pyridylsulf...
参考文献标题:2'6'-Dimethylphenoxyacetyl: A new achiral high affinity P3-P2 ligand for peptidomimetic-based HIV protease inhibitors
文献作者:Beaulieu,P.L.; Anderson,P.C.; Cameron,D.R.; Croteau,G.; Gorys,V.; Grand-Maitre,C.; Lamarre,D.; Liard,F.; Paris,W.; Plamondon,L.; Soucy,F.; Thibeault,D.; Wernic,D.; Yoakim,C.; Pav,S.; Tong,L.
参考来源:J Med Chem 2000,43(6),1094

MLN-977, LDP-977, CMI-977

(2S,5S)-1-[5-[5-(4-氟苯氧基甲基)四氢呋喃-2-基]-3-丁基]-1-羟基脲Chemical Name: (2S,5S)-1-[4-[5-(4-Fluorophenoxymethyl)tetrahydrofuran-2-yl]-3-butynyl]-1-hydroxyurea
CAS No. 175212-04-1
项目整合开发状态: Preclinical
项...
参考文献标题:Cpds.and methods for the treatment of cardiovascular,inflammatory and immune disorders
文献作者:Cai,X.; Grewal,G.; Hussoin,S.; Fura,A.; Scannell,R.; Biftu,T.; Qian,C.(CytoMed,Inc.)
参考来源:JP 1998506096; US 5703093; US 5792776; WO 9600212

Hapalosin

(2S,5S,6R,10R,11S)-10-庚基-6-羟基-4,11-二甲基-5-(苯基甲基)-2-丙-2-基-1,9-二氧杂-4-氮杂环十二烷-3,8,12-三酮Chemical Name: (2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-6-hydroxy-2-isopropyl-4,11-dimethyl-1,9-dioxa-4-azacyclododecane-...
参考文献标题:Studies toward the large-scale synthesis of the HIV proteinase inhibitor Ro 31-8959
文献作者:Parkes,K.E.B.; Bushnell,D.J.; Crackett,P.H.; et al.
参考来源:J Org Chem 1994,59(13),3656

CP-122721

(2s-顺式)-n-[[2-甲氧基-5-(三氟甲氧基)苯基]甲基]-2-苯基-3-哌啶胺Chemical Name: (+)-(2S,3S)-3-[2-Methoxy-5-(trifluoromethoxy)benzylamino]-2-phenylpiperidine
CAS No. 145742-28-5
项目整合开发状态: Phase II
项目研究机构: Pfizer (...
参考文献标题:Fluoroalkoxybenzylamino derivs.of nitrogen containing heterocycles
文献作者:Lowe,J.A.III; Rosen,T.J.(Pfizer Inc.)
参考来源:EP 0589924; JP 1994506473; WO 9300331

LFM-A13-F(oral formulation), LFM-A13

(2Z)-2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺 2-氰基-N-(2,5-二溴苯基)-3-羟基-2-丁烯酰胺 Chemical Name: (Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
CAS No. 244240-24-2, 62004-35-7 (undefined stereoch.)
项目整...
参考文献标题:Cyano acetic acid anilide derivs.,process for their manufacture and compsns.containing these cpds.
文献作者:Ertel,H.; Wolf,E.; Heubach,G.(Aventis SA)
参考来源:DE 2524929; US 4061767

L44

(2-叔丁基-4-环己基苯基)吡啶-3-羧酸酯Chemical Name: Pyridine-3-carboxylic acid 2-tert-butyl-4-cyclohexylphenyl ester
CAS No. 79781-87-6
项目整合开发状态: Phase II
项目研究机构: Merz (Originator)
合成路线:L44-O is prepare...
参考文献标题:L44/L44-O
文献作者:Quack,G.
参考来源:Drugs Fut 1987,12(4),349

Bromfenac sodium, AHR-10282B, AHR-10282(anhydrous), Xibrom, Bronuck, Duract

(2-氨基-3-(4-溴苯甲酰)苯基)乙酸钠溴芬酸钠 2-(2-氨基-3-(4-溴苯甲酰基)苯)乙酸Chemical Name: 2-[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid monosodium salt sesquihydrate; 2-Amino-3-(4-bromobenzoyl)benzeneacetic acid monosodium...
参考文献标题:2-Aminophenylacetic acid derivs.
文献作者:Moran,H.W.; Welstead,W.J.Jr.(A.H.Robins Co.Inc.)
参考来源:US 4126635