L44

(2-叔丁基-4-环己基苯基)吡啶-3-羧酸酯Chemical Name: Pyridine-3-carboxylic acid 2-tert-butyl-4-cyclohexylphenyl ester
CAS No. 79781-87-6
项目整合开发状态: Phase II
项目研究机构: Merz (Originator)
合成路线:L44-O is prepared by oxidizing L44 with 40% peracetic acid and the product is recristallized from ethanol.

合成路线:L44 is prepared by alkylating p-cyclohexylphenol (I) with iosobutene using Aberlyst A 15 as a catalyst.The raw mixture (II) is esterified with nicotinoyl chloride hydrochloride (III).The product is purified by recristallization from ethanol.