项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:636473

Chemical Name: 2-(4-tert-Butyl-2,6-dimethylbenzyl)-1,4,5,6-tetrahydropyrimidine
CAS No. 246544-20-7, 246544-18-3 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构: NPS Allelix (Originator),...
参考文献标题:Imidazoles with serotonin receptor binding activity
文献作者:Glennon,R.A.; Law,H.(NPS Allelix Corp.; Virginia Commonwealth University)
参考来源:US 5969137; WO 9812183

NS-3623

Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
CAS No. 265646-76-2
项目整合开发状态: Preclinical
项目研究机构: NeuroSearch (Originator)
合成路线:The title urea deri...
参考文献标题:Phenyl derivs.containing an acidic group,their preparation and their use as chloridic channel blockers
文献作者:Christophersen,P.; Pedersen,O.(NeuroSearch A/S)
参考来源:EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879

新产品编号:261539

Chemical Name: 1-[2-[3-(Benzyloxycarbonyl)phenyl]acetyl]-3(S)-(4-hydroxybenzyl)-4-oxoazetidine-2(S)-carboxylic acid benzyl ester
CAS No. 193959-27-2, 193959-22-7 (racemic, cis-isomer)
项目整合开发状态: ...
参考文献标题:Design,synthesis,and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen
文献作者:Adlington,R.M.; Baldwin,J.E.; Becker,G.W.; Chen,B.; Cheng,L.Y.; Cooper,S.L.; Hermann,R.B.; Howe,T.J.; McCoull,W.; McNulty,A.M.; Neubauer,B.L.; Pritchard,G.J.
参考来源:J Med Chem 2001,44(10),1491

新产品编号:862699

Chemical Name: 9(S),16-Diethyl-9-hydroxy-1,2,3,9,12,15-hexahydro-10H,13H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[3,2-f][1,4]benzoxazine-10,13-dione
CAS No. 344957-91-1
项目整合开发状态: Preclin...
参考文献标题:Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues
文献作者:Kim,D.-K.; Ryu,D.H.; Lee,J.Y.; Lee,N.; Kim,Y.W.; Kim,J.S.; Chang,K.; Im,G.J.; Kim,T.K.; Choi,W.S.
参考来源:J Med Chem 2001,44(10),1594

新产品编号:17911

Chemical Name: 2-[4-(1-Pyrrolidinyl)-2-butynyl]isoxazolidin-3-one
CAS No. 116445-17-1
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Milano (Originator), Universit?degli Studi di Parm...
参考文献标题:Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M
文献作者:Dallanoce,C.; Conti,P.; De Amici,M.; De Micheli,C.; Barocelli,E.; Chiavarini,M.; Ballabeni,V.; Bertoni,S.; Impicciatore,M.
参考来源:Bioorg Med Chem 1999,7(8),1539

CP-608039

Chemical Name: 3(S)-Amino-5(R)-[N6-[5-chloro-2-(3-methylisoxazol-5-ylmethoxy)benzyl]adenin-9-yl]-4(R)-hydroxy-N-methyltetrahydrofuran-2(S)-carboxamide; 3-Amino-1-[N6-[5-chloro-2-(3-methylisoxazol-5-yl...
参考文献标题:Cpds.for the treatment of ischemia
文献作者:Masamune,H.; Scott,R.W.; Deninno,M.P.(Pfizer Products Inc.)
参考来源:EP 1216257; JP 2003510331; WO 0123399

AMD-6221

Chemical Name: Potassium dihydrogen (OC-6-45)-[N-[2-[bis[(carboxy-kappaO)methyl]amino-kappaN]ethyl]-N-[2-[bis(carboxymethyl)amino]ethyl]glycinato(5-)-kappaN,kappaO]chlororuthenate(3-) monohydrate
C...
参考文献标题:Mechanistic studies on AMD6221: A ruthenium-based nitric oxide scavenger
文献作者:Mosi,R.; Seguin,B.; Cameron,B.; Amankwa,L.; Darkes,M.C.; Fricker,S.P.
参考来源:Biochem Biophys Res Commun 2002,292(2),519

AL-6598

Chemical Name: (5Z,9R,11R,15R)-9-Chloro-15-cyclohexyl-11,15-dihydroxy-3-oxa-16,17,18,19,20-pentanorprosta-5-enoic acid isopropyl ester; 2-[4-[(1R,2R,3R,5R)-5-Chloro-2-[3(R)-cyclohexyl-3-hydroxypropyl]...
参考文献标题:3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents
文献作者:Hellberg,M.R.; Conrow,R.E.; Sharif,N.A.; McLaughlin,M.A.; Bishop,J.E.; Crider,J.Y.; Dean,W.D.; DeWolf,K.A.; Pierce,D.R.; Sallee,V.L.; Selliah,R.D.; Severns,B.S.; Sproull,S.J.; Williams,G.W.; Zinke,P.W.; Klimko,P.G.
参考来源:Bioorg Med Chem 2002,10(6),2031

新产品编号:625399

Chemical Name: 1,8-Dihydroxy-10-(4-phenylpentanoyl)anthracen-9(10H)-one
CAS No. 241803-78-1
项目整合开发状态: Biological Testing
项目研究机构: Teva (Originator)
合成路线:Acylation of anthralin (I) either wi...
参考文献标题:10-Substd.18-dihydroxy-9(10H)anthracenone pharmaceuticals
文献作者:Reindl,H.; Muller,K.; Weigrebe,W.(Teva Pharmaceutical Industries Ltd.)
参考来源:US 5952390

DPJ-489

Chemical Name: 1-[(3beta,16beta,17beta)-17-(Acetoxy)-3-(1-methylpyrrolidinio)androst-5-en-16-yl]-1-methylpiperidinium diiodide; (3beta,16beta,17beta)-17-(Acetoxy)-16-(1-methylpiperidinium-1-yl)-3-(1-m...
参考文献标题:Synthesis and neuromuscular blocking activity of 16beta-piperidinosteroidal derivatives
文献作者:Jindal,D.P.; Piplani,P.; Fajrak,H.; Prior,C.; Marshall,I.G.
参考来源:Eur J Med Chem 2001,36(2),195