项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:778853

Chemical Name: 7-(2,4-Dichlorophenyl)-2-ethyl-3-(1-ethylpentyl)pyrazolo[1,5-a]pyrimidine
CAS No. 300709-77-7
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Rea...
参考文献标题:Pyrazolopyrimidines as CRF antagonists
文献作者:Gilligan,P.J.; Wilde,R.G.(DuPont Pharmaceuticals Co.)
参考来源:WO 0059908

GP-49

Chemical Name: N-(5-Chloropyridin-2-yl)-N'-[2-(2,6-difluorophenyl)ethyl]thiourea
CAS No. 149487-93-4
项目整合开发状态: Biological Testing
项目研究机构: Medivir (Originator)
合成路线:Treatment of 2-amino-5-b...
参考文献标题:Cpds.and methods for inhibition of HIV and related viruses
文献作者:Lind,P.T.; Noreen,R.; Ternansky,R.J.; Morin,J.M.Jr.(Medivir AB)
参考来源:WO 9303022

新产品编号:60625

Chemical Name: 12-Ethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
CAS No. 152628-27-8
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Th...
参考文献标题:Further indole derivs.with antiviral activity
文献作者:Slater,M.J.; Cockerill,G.S.; Littler,E.; Yeates,C.L.(Glaxo Wellcome plc)
参考来源:US 5547976; WO 9318766

AAD-777, ZK-202664, NVP-AAD-777

Chemical Name: N-[3,4-Bis(trifluoromethyl)phenyl]-4-(pyridin-4-ylmethyl)phthalazin-1-amine
CAS No. 300842-59-5
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator), Schering AG (Codevelopment)...
参考文献标题:Phthalazine derivs.for treating inflammatory diseases
文献作者:Wietfeld,B.; Wood,J.M.; Manley,P.W.; Heng,R.; Frei,J.; Bold,G.; Dawson King,J.(Novartis AG)
参考来源:WO 0059509

BL-3730

Chemical Name: 2-[N-[2-(3-Carboxymethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]-L- valyl-L-prolyl-L-valyl]benzoxazole; 2-[3-{2-[1(S)-[2(S)-[N-[1(S)-(Benzoxazol-2-ylcarbonyl)-2-methylpropyl]...
参考文献标题:Heterocyclic cpds.,intermediates thereof and elastase inhibitors
文献作者:Sato,F.; Inoue,Y.; Honda,S.; Komiya,M.; Takemura,T.; Omodani,T.; Shiratake,R.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:EP 1157998; JP 2000256396; WO 0052032

LY-465608

Chemical Name: 2-[4-[2-[2-(Biphenyl-4-yl)-5-methyloxazol-4-yl]ethoxy]phenoxy]-2-methylpropionic acid
CAS No. 328918-26-9
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator), Lilly (Originator)<...
参考文献标题:Biaryl-oxa(thia)zole derivs.and their use as PPARs modulators
文献作者:Matthews,D.P.; Hay,D.A.; Ardecky,R.J.; Warshawsky,A.M.; Gossett,L.S.; Dominianni,S.J.; Rito,C.J.; Shuker,A.J.; Brooks,D.A.; Michellys,P.-Y.; Tyhonas,J.S.(Eli Lilly and Company; Ligand Pharmaceuticals,Inc.)
参考来源:EP 1206457; US 6417212; WO 0116120

新产品编号:827895

Chemical Name: Dodecane-1,12-diol mixed ester with N-[4-(3-Aminopropyl)-8,13,13-tris[3-[N,N-bis(3-aminopropyl)amino]propyl]-4,8,13-triazatridecyl]carbamate and N-[4,9,9-tris[3-[6-(beta-D-galactopyrano...
参考文献标题:Synthesis of bifunctional cationic compound for gene delivery
文献作者:Ren,T.; et al.
参考来源:Tetrahedron Lett 2001,42(6),1007

SC-964, SC-77964

Chemical Name: 1-Cyclopropyl-5-[4-[4-(trifluoromethoxy)phenoxy]phenylsulfonyl]piperidine-3-carbohydroxamic acid hydrochloride
CAS No. 226396-02-7, 308824-37-5 (free base)
项目整合开发状态: Preclinical 参考文献标题:Aromatic sulfone hydroxamic acid metalloprotease inhibitor
文献作者:Becker,D.P.; Mischke,D.A.; Villamil,C.I.; Bedell,L.J.; Fobian,Y.M.; Hanson,G.J.; Rico,J.G.; Barta,T.E.; Kolodziej,S.A.; Tollefson,M.B.; Stehle,N.W.; Howard,S.C.; Getman,D.P.; (Pharmacia Corp.)
参考来源:WO 0050396

新产品编号:721901

Chemical Name: 6,7-Dimethyl-3-[4-(4-nitrophenyl)piperazin-1-yl]quinoxaline-2-carbonitrile 1,4-dioxide
CAS No. 266363-30-8
项目整合开发状态: Preclinical
项目研究机构: Universidad de Navarra (Originator), Un...
参考文献标题:Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides
文献作者:Monge,A.; Palop,J.A.; Lopez de Cerain,A.; Senador,V.; Martinez-Crespo,F.J.; Sainz,Y.; Narro,S.; Garcia,E.; de Miguel,C.; Gonzalez,M.D.; et al.
参考来源:J Med Chem 1995,38(10),1786

新产品编号:59043

Chemical Name: 1-(2-Adamantyl)-1-(4-fluorophenyl)-1-(perhydropyrrolizin-7a-yl)methanol hydrochloride
CAS No. 152530-37-5, 152530-36-4 (free base)
项目整合开发状态: Preclinical
项目研究机构: Sanwa (Originat...
参考文献标题:Antivirally active N-cycloalkyl alkanol cpds.
文献作者:Kurono,M.; Baba,Y.; Oka,M.; Honda,N.; Matsumoto,Y.; Kakigami,T.; Iwata,N.; Ishiwata,Y.; Ohtuka,T.; Mitani,T.; Sawai,K.(Sanwa Kagaku Kenkyusho Co.,Ltd.)
参考来源:EP 0558321; JP 1994048997