NS-3623
Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
CAS No. 265646-76-2
项目整合开发状态: Preclinical
项目研究机构: NeuroSearch (Originator)
合成路线:The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).
合成路线:The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.
📌 参考资料/链接:
参考文献标题:Phenyl derivs.containing an acidic group,their preparation and their use as chloridic channel blockers
文献作者:Christophersen,P.; Pedersen,O.(NeuroSearch A/S)
参考来源:EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879