项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

TBC-2576

Chemical Name: 3-[N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl]-N-(3-hydroxy-2,4,6-trimethylphenyl)thiophene-2-carboxamide
CAS No. 205515-63-5
项目整合开发状态: Preclinical
项目研究机构: Encysive Pharmaceut...
参考文献标题:Sulfonamides for treatment of endothelin-mediated disorders
文献作者:Blok,N.; Keller,K.; Wu,C.; Kogan,T.; Woodard,P.(Texas Biotechnology Corp.)
参考来源:EP 0980369; US 5783705; WO 9849162

3-Methyl-cycloSal-ACVMP

Chemical Name: 2-Amino-9-[2-(8-methyl-2-oxo-4H-1,3,2-benzodioxaphosphinin-2-yloxy)ethoxymethyl]-1,9-dihydro-6H-purin-6-one; 9-[2-(8-Methyl-2-oxo-4H-1,3,2-benzodioxaphosphinin-2-yloxy)ethoxymethyl]guan...
参考文献标题:Chemistry and anti-herpes simplex virus type 1 evaluation of cycloSal-nucleotides of acyclic nucleoside analogues
文献作者:Meier,C.; Habel,L.; Haller-Meier,F.; Lomp,A.; Herderich,M.; Kl鯿king,R.; Meerbach,A.; Wutzler,P.
参考来源:Antivir Chem Chemother 1998,9389

新产品编号:122323

Chemical Name: (11aS)-7-Methoxy-8-(oxiranylmethoxy)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
CAS No. 171229-23-5 ([R-(R*, S*)]-isomer), 171002-52-1 ([S-(R*,R*)]-isomer)
项目整...
参考文献标题:Design and synthesis and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2,1-c][1,4]benzodiazepine system
文献作者:Wilson,S.C.; Howard,P.W.; Forrow,S.M.; Hartley,J.A.; Adams,L.J.; Jenkins,T.C.; Kelland,L.R.; Thurston,D.E.
参考来源:J Med Chem 1999,42(20),4028

新产品编号:606415

Chemical Name: (+)-N1-(5-Bromo-2-pyridinyl)-N2-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-propionylphenyl)cyclopropyl]urea
CAS No. 231957-56-5, 231957-57-6 (enantiomer)
项目整合开发状态: Preclinical
项目研究机构: Me...
参考文献标题:Antivirals
文献作者:Nor閑n,R.; H鰃berg,M.; Engelhardt,P.; Sahlberg,C.(Medivir AB)
参考来源:WO 9936406

新产品编号:193513

Chemical Name: cis-8-(3-Amino-4-methylpiperidinyl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid
CAS No. 186198-72-1 (non-specific stereoch.)
项目整合开发状态: Preclinical
项目...
参考文献标题:Quinolizinone type cpds.
文献作者:Chu,D.T.; Li,Q.; Cooper,C.S.; Fung,A.K.L.; Lee,C.M.; Plattner,J.J.; Ma,Z.; Wang,W.-B.(Abbott Laboratories Inc.)
参考来源:EP 0871628; JP 1999510478; WO 9639407

FUB-407

Chemical Name: 4-[3-(3,3-Dimethylbutoxy)propyl]-1H-imidazole
CAS No. 184020-57-3 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bioprojet (Originator), INSERM (Originator)
合成路线:Treatment of alc...
参考文献标题:Novel partial agonists for the histamine H3 receptor with high in vitro and in vivo activity
文献作者:Sasse,A.; Stark,H.; Reidemeister,S.; Huls,A.; Elz,S.; Ligneau,X.; Ganellin,C.R.; Schwartz,J.C.; Schunack,W.
参考来源:J Med Chem 1999,42(20),4269

新产品编号:248883

Chemical Name: N-[N-[5-Methyl-5-(methylamino)-2(E)-hexenoyl]-N-methyl-3-(2-naphthyl)-D-alanyl]-N-methyl-D-phenylalanine methylamide
CAS No. 193079-71-9
项目整合开发状态: Biological Testing
项目研究机构: No...
参考文献标题:Cpds.with growth hormone releasing properties
文献作者:Hansen,T.K.; Peschke,B.; Lau,J.; Lundt,B.F.; Ankersen,M.; Watson,B.; Madsen,K.(Novo Nordisk A/S)
参考来源:JP 1999209336; JP 1999501054; JP 2000143613; US 6127391; WO 9723508

PNU-107859

Chemical Name: N-Methyl-3-phenyl-2(S)-[3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)ureido]propionamide
CAS No. 198700-58-2
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The reac...
参考文献标题:Thiadiazolyl(thio)ureas useful as matrix metalloprotease inhibitors
文献作者:Jacobsen,E.J.; Mitchell,M.A.; Schostarez,H.J.; Harper,D.E.(Pharmacia & Upjohn AB)
参考来源:EP 0900211; JP 2000509039; WO 9740031

HI-346

Chemical Name: N-(5-Bromopyridin-2-yl)-N'-[2-(1-cyclohexenyl)ethyl]thiourea
CAS No. 167683-78-5
项目整合开发状态: Preclinical
项目研究机构: Medivir (Originator), Parker Hughes Institute (Codevelopment)
...
参考文献标题:Cpds.and methods for inhibition of HIV and related viruses
文献作者:Lind,P.T.; Noreen,R.; Ternansky,R.J.; Morin,J.M.Jr.(Medivir AB)
参考来源:WO 9303022

HI-445

Chemical Name: N-(5-Chloropyridin-2-yl)-N'-[2-(cyclohex-1-en-1-yl)ethyl]thiourea
CAS No. 149488-07-3, 240417-29-2 (error)
项目整合开发状态: Preclinical
项目研究机构: Medivir (Originator), Parker Hughes Ins...
参考文献标题:Cpds.and methods for inhibition of HIV and related viruses
文献作者:Lind,P.T.; Noreen,R.; Ternansky,R.J.; Morin,J.M.Jr.(Medivir AB)
参考来源:WO 9303022