3-Methyl-cycloSal-ACVMP

Chemical Name: 2-Amino-9-[2-(8-methyl-2-oxo-4H-1,3,2-benzodioxaphosphinin-2-yloxy)ethoxymethyl]-1,9-dihydro-6H-purin-6-one; 9-[2-(8-Methyl-2-oxo-4H-1,3,2-benzodioxaphosphinin-2-yloxy)ethoxymethyl]guanine
CAS No. 217434-36-1
项目整合开发状态: Biological Testing
项目研究机构: Friedrich-Schiller-Universit鋞 Jena (Originator), Julius-Maximilians-Universit鋞 (Originator)
合成路线:The condensation of acyclovir (I) with the cyclic chlorophosphane (II) in the presence of N,N-diisopropyl ethylamine afforded the acyclovir phosphite ester (III).This was then oxidized to the target phosphate using tert-butyl hydroperoxide.