项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

N276-26

Chemical Name: 4-(2,2-Diphenylethyl)-2-methyl-6-[4-(2-isopropyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 5-ethyl 3-[3-(3-pyridinyl)prop-2-ynyl] diester
CAS No...
参考文献标题:1,4-Dihydropyridine derivs.
文献作者:Tasaka,S.; Omori,H.; Tanabe,H.; Gomi,N.; Kiue,A.(Nikken Chemicals Co.,Ltd.)
参考来源:EP 1055672; JP 2000044559; US 6306853; WO 9941250

新产品编号:90683

Chemical Name: (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-methyl-5-oxopyrrolidin-3(R)-ylsulfanyl]-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester
CAS No. 162599-62-4, 127423-15-8 (und...
参考文献标题:2-(Heterocyclylthio)carbapenem derivs.their preparation and their use as antibiotics
文献作者:Kawamoto,I.; Tanaka,T.; Endo,R.; Miyauchi,M.; Iwata,M.(Sankyo Co.,Ltd.)
参考来源:AU 8932386; EP 0337637; EP 0597821; JP 1990028180; JP 1990049783; US 5104867; US 5242914

新产品编号:92265

Chemical Name: (1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-methyl-5-oxopyrrolidin-3(S)-ylsulfanyl]-1-carba-2-penem-3-carboxylic acid pivaloyloxymethyl ester
CAS No. 162599-64-6, 127423-15-8 (und...
参考文献标题:2-(Heterocyclylthio)carbapenem derivs.their preparation and their use as antibiotics
文献作者:Kawamoto,I.; Tanaka,T.; Endo,R.; Miyauchi,M.; Iwata,M.(Sankyo Co.,Ltd.)
参考来源:AU 8932386; EP 0337637; EP 0597821; JP 1990028180; JP 1990049783; US 5104867; US 5242914

新产品编号:155545

Chemical Name: (+)-1'-Methylspiro[5,10-dihydro-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-10,2'-pyrrolidin]-4-one
CAS No. 179174-42-6, 179174-43-7 ((-)-enantiomer), 179174-41-5 (racemate)
项目整合开发状态: P...
参考文献标题:Spiro[heterocycle-imidazo[1,2-a]indeno[1,2-e]pyrazine]-4'-ones,preparation thereof and drugs containing same
文献作者:Aloup,J.-C.; Audiau,F.; Barreau,M.; Damour,D.; Genevois-Borella,A.; Jimonet,P.; Mignani,S.; Ribeill,Y.(Aventis Pharma SA)
参考来源:JP 1998508311; US 5777114; WO 9614318

新产品编号:199841

Chemical Name: (5R,6S)-2-(4-Amidinodibenzofuran-2-yl)-6-[1(R)-hydroxyethyl]-1-carba-2-penem-3-carboxylic acid inner salt
CAS No. 186822-13-9
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Origina...
参考文献标题:2-(Dibenzofuranyl)- and 2-(dibenzothienyl)-carbapenems,compsns.containing such cpds.and methods of use
文献作者:Greenlee,M.L.; Laub,J.B.(Merck & Co.,Inc.)
参考来源:GB 2301820

SUN-N5030

Chemical Name: 1-Phenoxy-3-[4-(4-phenoxyphenyl)piperidin-1-yl]-2-propanol hydrochloride
CAS No. 254432-70-7, 254432-72-9 ((R)-isomer), 254432-73-0 ((S)-isomer)
项目整合开发状态: Preclinical
项目研究机构: D...
参考文献标题:A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects
文献作者:Annoura,H.; Nakanishi,K.; Uesugi,M.; Fukunaga,A.; Miyajima,A.; Tamura-Horikawa,Y.; Tamura,S.
参考来源:Bioorg Med Chem Lett 1999,9(20),2999

新产品编号:115995

Chemical Name: 1-(3-Carbamoyl-3,3-diphenylpropyl)-3-(4-bromobenzyl)-2-methyl-1H-imidazol-3-ium bromide
CAS No. 170105-47-2
项目整合开发状态: Biological Testing
项目研究机构: Kyorin (Originator)
合成路线:Alk...
参考文献标题:Novel imidazole deriv.and process for producing the same
文献作者:Miyachi,H.; Okazaki,K.; Kiyota,H.; Segawa,M.(Kyorin Pharmaceutical Co.,Ltd.)
参考来源:EP 0733621; US 5932607; US 6103747; WO 9515951

新产品编号:598505

Chemical Name: cis-4-[N-(1-Allyl-3-methylpiperidin-4-yl)-N-phenylamino]-N,N-diethylbenzamide
CAS No. 229478-44-8, 244048-67-7 (hydrochloride)
项目整合开发状态: Biological Testing
项目研究机构: Ortho-McNeil...
参考文献标题:Novel opiate cpds.,methods of making and methods of use
文献作者:Carroll,F.I.
参考来源:WO 9945925

WAY-VNA-932, VNA-932

Chemical Name: 10-[2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine; [2-Chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl](10,11-dihydro-5H-pyrrolo[2,1-c][1,4]b...
参考文献标题:Tricyclic vasopressin agonists
文献作者:Trybulski,E.J.; Ashwell,M.A.; Molinari,A.J.; Bagli,J.F.; Chan,P.S.; Failli,A.A.; Dusza,J.P.; Albright,J.D.; Caggiano,T.J.(American Home Products Corp.)
参考来源:EP 1000062; WO 9906409

PNU-171829

Chemical Name: 2-[1-[1(S)-Cyclohexyl-1-(N-methylcarbamoyl)methyl]-3(S)-isobutyl- 2-oxopyrrolidin-3-yl]acetohydroxamic acid
CAS No. 196950-60-4
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator...
参考文献标题:Hydroxamic acid derivs.for use with the treatment of diseases related to connective tissue degradation
文献作者:Jacobsen,E.J.(Pharmacia & Upjohn AB)
参考来源:EP 0898562; JP 2000506163; US 5712300; WO 9732846