项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:253629

Chemical Name: 3-(4-Hydroxyphenyl)-N-(4-phenylbutyl)-2(E)-propenamide
CAS No. 193219-34-0
项目整合开发状态: Biological Testing
项目研究机构: CoCensys (Originator), Oregon Health and Science University (Ori...
参考文献标题:Subtype-selective NMDA receptor ligands and the use thereof
文献作者:Cai,S.X.; Keana,J.F.W.; Lan,N.C.; Araldi,G.L.; Tamiz,A.; Zhou,Z.-L.; Woodward,R.M.; Whittemore,E.R.; Weber,E.(Acea Pharmaceuticals; CoCensys,Inc.; Oregon Health Sciences University; University of Oregon)
参考来源:WO 9723202

新产品编号:630145

Chemical Name: 2-[[3-[N'-[4-Chloro-3-(trifluoromethyl)phenyl]ureido]-3-deoxy-2-O-[2-deoxy-2-[3-(trifluoromethyl)benzamido]-beta-D-glucopyranosyl]-4-O-methyl-alpha-D-glucopyranos-1-yloxyuronamide](hydr...
参考文献标题:Discovery of novel disaccharide antibacterial agents using a combinatorial library approach
文献作者:Sofia,M.J.; Allanson,N.; Hatzenbuhler,N.T.; Jain,R.; Kakarla,R.; Kogan,N.; Liang,R.; Liu,D.; Silva,D.J.; Wang,H.; Gange,D.; Anderson,J.; Chen,A.; Chi,F.; Dulina,R.; Huang,B.; Kamau,M.; Wang,C.; Baizman,E.; Branstrom,A.; et al.
参考来源:J Med Chem 1999,42(17),3193

新产品编号:221989

Chemical Name: 12-Amino-3-fluoro-9-methyl-6,7,10,11-tetrahydro-7(S),11(S)-methanocycloocta[b]quinoline
CAS No. 189499-39-6 (racemate), 189499-40-9 (racemic, HCl)
项目整合开发状态: Biological Testing
...
参考文献标题:Polycyclic aminopyridine cpds.which are acetylcholinesterase inhibitors,process for preparing them and their use
文献作者:Contreras Lascorz,J.; El Achab,R.; Camps Garcia,P.; Ba駉s Diez,J.E.; Mu駉z-Torrero Lopez-Ibarra,D.; Badia Sancho,A.; Morral Cardoner,J.; Simon Fornell,M.; Gbig Romeu,M.; Vivas,N.M.(Medichem SA)
参考来源:EP 0796849; ES 2100129; US 5965569; WO 9713754

新产品编号:223571

Chemical Name: 12-Amino-9-methyl-6,7,10,11-tetrahydro-7(S),11(S)-methanocycloocta[b]quinoline
CAS No. 189500-02-5, 189500-04-7 (as hydrochloride), 189500-03-6 (enantiomer), 189499-35-2 (racemate), ...
参考文献标题:Polycyclic aminopyridine cpds.which are acetylcholinesterase inhibitors,process for preparing them and their use
文献作者:Contreras Lascorz,J.; El Achab,R.; Camps Garcia,P.; Ba駉s Diez,J.E.; Mu駉z-Torrero Lopez-Ibarra,D.; Badia Sancho,A.; Morral Cardoner,J.; Simon Fornell,M.; Gbig Romeu,M.; Vivas,N.M.(Medichem SA)
参考来源:EP 0796849; ES 2100129; US 5965569; WO 9713754

新产品编号:331147

Chemical Name: 5(R)-(Acetylamino)-2(S)-(5-bromo-1H-indol-3-yloxy)-6(R)-[2(R),3-dihydroxy-1(R)-methoxypropyl]-4(S)-methoxytetrahydro-2H-pyran-2-carboxylic acid
CAS No. 203447-96-5
项目整合开发状态: Biolo...
参考文献标题:4,7-Dialkoxy N-acetylneuraminic acid derivs.and methods for detection of influenza type A and B viruses in clinical specimens
文献作者:Shimasaki,C.D.; Liav,A.; Hansjergen,J.A.(Oklahoma Medical Research Foundation)
参考来源:US 5719020; WO 9813372

L-beta-BV-OddU, BCH-2639

Chemical Name: 5-[(E)-2-Bromovinyl]-1-[2(S)-(hydroxymethyl)-1,3-dioxolan-4(S)-yl]pyrimidine-2,4(1H,3H)-dione; 5-[(E)-2-Bromovinyl)-1-[2(S)-(hydroxymethyl)-1,3-dioxolan-4(S)-yl]uracil
CAS No. 161105...
参考文献标题:5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
文献作者:Chu,C.K.; Cheng,Y.-C.; Li,L.; Chai,Y.(University of Georgia; Yale University)
参考来源:CA 2378370; EP 1204415; US 6653318; WO 0106986

新产品编号:191931

Chemical Name: (3S,4R)-4-[N''-(4-Chlorophenyl)-N'-cyanoguanidino]-3-hydroxy-N,N-bis(isobutyl)-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-sulfonamide; (3S,4R)-N-(4-Chlorophenyl)-N'-cyano-N''-[6-(diisob...
参考文献标题:Sulfonamido substd.benzopyran potassium channel activators
文献作者:Ding,C.Z.; Atwal,K.S.(Bristol-Myers Squibb Co.)
参考来源:CA 2178353; EP 0747374; JP 1997003035; US 5869478

新产品编号:445051

Chemical Name: N-[5-[N-Benzyl-N-(3-pyridyl)aminomethyl]-2'-methylbiphenyl-2-ylcarbonyl]-L-methionine; 2(S)-[5-[N-Benzyl-N-(3-pyridyl)aminomethyl]-2'-methylbiphenyl-2-ylcarboxamido]-4-(methylsulfanyl)b...
参考文献标题:Second-generation peptidomimetic inhibitors of protein farnesyltransferase demonstrating improved cellular potency and significant in vivo efficacy
文献作者:O'Connor,S.; Barr,K.J.; Wang,L.; Sorensen,B.K.; Tasker,A.S.; Sham,H.; Ng,S.C.; Cohen,J.; Devine,E.; Cherian,S.; Saeed,B.; Zhang,H.; Lee,J.Y.; Warner,R.; Tahir,S.; Kovar,P.; Ewing,P.; Alder,J.; Mitten,M.; Leal,J.; Marsh,K.; et al.
参考来源:J Med Chem 1999,42(18),3701

新产品编号:634891

Chemical Name: 2-[4-[2(R)-[3(S),5(R)-Dimethyl-2-oxo-1(S)-cyclohexyl]-2-hydroxyethyl]-2,6-dioxopiperidin-1-yl]acetic acid ethyl ester
CAS No. 246257-13-6
项目整合开发状态: Preclinical
项目研究机构: Friedric...
参考文献标题:Cyclohexamide derivs.which influence the regeneration of neural tissue
文献作者:Thiericke,R.; Fischer,G.; K黮lertz,G.; Christner,C.; Grabley,S.; Wyrwa,R.(Hans Kn鰈l Institute for Natural Product Research; Max-Planck-Gesellschaft zur Fderung der Wissenschaften e.V.)
参考来源:WO 0026188

9-Aminocamptothecin glucuronide, 9-ACG

Chemical Name: 1-O-[4-[N-[4(S)-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-10-yl]carbamoyloxymethyl]phenyl]-beta-D-glucuronic acid
CAS No. 246032-5...
参考文献标题:Proactive antitumor cpds.
文献作者:Chern,J.-W.; Roffler,S.; Leu,Y.-L.(Academia Sinica)
参考来源:EP 0990661; US 6043367