新产品编号:253629
Chemical Name: 3-(4-Hydroxyphenyl)-N-(4-phenylbutyl)-2(E)-propenamide
CAS No. 193219-34-0
项目整合开发状态: Biological Testing
项目研究机构: CoCensys (Originator), Oregon Health and Science University (Originator), Pfizer (Originator), University of Oregon (Originator)
合成路线:The title compound was prepared by treatment of 4-hydroxycinnamic acid (I) with CDI to produce the corresponding imidazolide (II),which was then coupled with 4-phenylbutyl amine (III) in THF at r.t.
📌 参考资料/链接：
参考文献标题:Subtype-selective NMDA receptor ligands and the use thereof
文献作者:Cai,S.X.; Keana,J.F.W.; Lan,N.C.; Araldi,G.L.; Tamiz,A.; Zhou,Z.-L.; Woodward,R.M.; Whittemore,E.R.; Weber,E.(Acea Pharmaceuticals; CoCensys,Inc.; Oregon Health Sciences University; University of Oregon)
参考来源:WO 9723202
📄 详细内容
合成路线:The title compound was prepared by treatment of 4-hydroxycinnamic acid (I) with CDI to produce the corresponding imidazolide (II),which was then coupled with 4-phenylbutyl amine (III) in THF at r.t.
参考文献标题:Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists
文献作者:Tamiz,A.P.; Cai,S.X.; Zhou,Z.L.; Yuen,P.W.; Schelkun,R.M.; Whittemore,E.R.; Weber,E.; Woodward,R.M.; Keana,J.F.
参考来源:J Med Chem 1999,42(17),3412