新产品编号:634891
Chemical Name: 2-[4-[2(R)-[3(S),5(R)-Dimethyl-2-oxo-1(S)-cyclohexyl]-2-hydroxyethyl]-2,6-dioxopiperidin-1-yl]acetic acid ethyl ester
CAS No. 246257-13-6
项目整合开发状态: Preclinical
项目研究机构: Friedrich-Schiller-Universit鋞 Jena (Originator), Hans Kn鰈l Institute Natural Prod. Res. (Originator), Max-Planck-Gesellschaft (Originator)
合成路线:By condensation of cycloheximide (I) with ethyl 2-bromoacetate (II) by means of K2CO3 and 18-crown-6 in acetone.
📌 参考资料/链接：
参考文献标题:Cyclohexamide derivs.which influence the regeneration of neural tissue
文献作者:Thiericke,R.; Fischer,G.; K黮lertz,G.; Christner,C.; Grabley,S.; Wyrwa,R.(Hans Kn鰈l Institute for Natural Product Research; Max-Planck-Gesellschaft zur Fderung der Wissenschaften e.V.)
参考来源:WO 0026188
📄 详细内容
合成路线:By condensation of cycloheximide (I) with ethyl 2-bromoacetate (II) by means of K2CO3 and 18-crown-6 in acetone.
参考文献标题:Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties
文献作者:Christner,C.; Wyrwa,R.; Marsch,S.; K黮lertz,G.; Thiericke,R.; Grabley,S.; Schummann,D.; Fischer,G.
参考来源:J Med Chem 1999,42(18),3615