项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:346967

Chemical Name: 1-Benzoyl-3(R)-(3,4-dichlorophenyl)-3-[3-(4-hydroxy-4-phenylpiperidin-1-yl)propyl]piperidine
CAS No. 204642-53-5
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The p...
参考文献标题:3-Alkyl-3-phenyl-piperidines
文献作者:Chen,M.H.G.; Lee,H.T.; Chung,F.-Z.(Pfizer Inc.)
参考来源:WO 9811090

新产品编号:498839

Chemical Name: Tetradecanoic acid (1S*,3aS*,8R*,11R*,11aS*)-11,11a-dihydroxy-10-(hydroxymethyl)-12-oxo-3a,8-methano-1,4,5,6,7,8,11,11a-octahydro-3aH-cyclopentacyclodecen-1-yl ester
CAS No. 220088-1...
参考文献标题:Synthesis and biological evaluation of highly functionalized analogues of ingenol
文献作者:Winkler,J.D.; Lewin,N.E.; Blumberg,P.M.; Harrison,S.; Kim,S.
参考来源:J Am Chem Soc 1999,121(2),296

新产品编号:497257

Chemical Name: Nonanoic acid (1S*,3aS*,8R*,11R*,11aS*)-11,11a-dihydroxy-10-(hydroxymethyl)-12-oxo-3a,8-methano-1,4,5,6,7,8,11,11a-octahydro-3aH-cyclopentacyclodecen-1-yl ester
CAS No. 220088-15-3 参考文献标题:Synthesis and biological evaluation of highly functionalized analogues of ingenol
文献作者:Winkler,J.D.; Lewin,N.E.; Blumberg,P.M.; Harrison,S.; Kim,S.
参考来源:J Am Chem Soc 1999,121(2),296

94-245

Chemical Name: 2-Cyano-3-[4-(ethoxycarbonylmethoxy)-3-methoxyphenyl]-2(Z)-propenoic acid ethyl ester
CAS No. 151474-34-9 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Central Drug Research...
参考文献标题:Synthesis and antileishmanial activity of alpha-cyano ethyl propenoates - A new class of antileishmanials
文献作者:Tiwari,S.; et al.
参考来源:Arzneim-Forsch Drug Res 1999,49(2),144

MPB-27

Chemical Name: 7-Chloro-6-hydroxybenzo[c]quinolizinium chloride
CAS No. 191091-58-4
项目整合开发状态: Biological Testing
项目研究机构: INSERM (Originator)
合成路线:The condensation of 2-methylpyridine (I) w...
参考文献标题:CFTR channel activator cpds.and pharmaceutical compsns.containing same
文献作者:Becq,F.; Mettey,Y.; Vierfond,J.-M.; Verrier,B.; Gola,M.(CNRS (Centre National de la Recherche Scientifique))
参考来源:EP 0937044; WO 9805642

SF-303

Chemical Name: (?-2-[3-(3-Amidinophenyl)-5-[N-(2'-sulfamoylbiphenyl-4-yl)carbamoyl]-4,5-dihydroisoxazol-5-yl]acetic acid methyl ester trifluoroacetate
CAS No. 193003-99-5, 193003-98-4 (free base) 参考文献标题:Isoxazoline,isothiazoline and pyrazoline factor Xa inhibitors
文献作者:Quan,M.L.; Wityak,J.; Galemmo,R.A.Jr.; Stouten,P.F.W.; Pruitt,J.R.(DuPont Pharmaceuticals Co.)
参考来源:EP 0874629; US 5939418; WO 9723212

GR-891

Chemical Name: 5-Fluoro-1-[3-(2-hydroxyethoxy)-1-(isopropoxy)propyl]pyrimidine-2,4(1H,3H)-dione
CAS No. 138969-77-4 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Universidad de Granada (Or...
参考文献标题:New uracil derivs.having an anti-tumour activity and related cpds.(N-1 derivs.of 5-substd.-uracile)
文献作者:Campos Rosa,J.; Gallo Mezo,M.A.; Dominguez Senglar,J.F.; Entrena Guadix,A.; Pineda de las Infantas y Villatoro,M.J.; Camacho Quesada,E.; Espinosa Ubeda,A.(Universidad de Granada)
参考来源:WO 9117147

新产品编号:93847

Chemical Name: N-[4-(3-Hydroxypropyl)-1,2,3,6-tetrahydropyridin-1-yl]pyridine-2-carboxamide
CAS No. 163080-90-8
项目整合开发状态: Preclinical
项目研究机构: University of Florida (Originator)
合成路线:The co...
参考文献标题:Synthesis of some N-[pyridyl(phenyl)carbonylamino]hydroxyalkyl(benzyl)-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents
文献作者:Rao,K.N.; et al.
参考来源:J Heterocycl Chem 1995,32(1),307

新产品编号:321655

Chemical Name: 3-(4-Phenoxyphenylsulfonyl)-1-propanethiol
CAS No. 202665-41-6
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Alkylation of 4-fluorothiophenol (I) with 3-chlo...
参考文献标题:Thiol sulfone metalloprotease inhibitors
文献作者:Freskos,J.N.; Abbas,Z.S.; Decrescenzo,G.A.; Getman,D.P.; Heintz,R.M.; Mischke,B.V.; McDonald,J.J.(Pharmacia Corp.)
参考来源:EP 0939628; WO 9803164

新产品编号:320073

Chemical Name: 3-(4-Phenylsulfanylphenylsulfonyl)-1-propanethiol
CAS No. 202665-40-5
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Alkylation of 4-fluorothiophenol (I) with...
参考文献标题:Thiol sulfone metalloprotease inhibitors
文献作者:Freskos,J.N.; Abbas,Z.S.; Decrescenzo,G.A.; Getman,D.P.; Heintz,R.M.; Mischke,B.V.; McDonald,J.J.(Pharmacia Corp.)
参考来源:EP 0939628; WO 9803164