新产品编号:93847

Chemical Name: N-[4-(3-Hydroxypropyl)-1,2,3,6-tetrahydropyridin-1-yl]pyridine-2-carboxamide
CAS No. 163080-90-8
项目整合开发状态: Preclinical
项目研究机构: University of Florida (Originator)
合成路线:The condensation of 4-(3-hydroxypropyl)pyridine (I) with 2,4-dinitrochlorobenzene (II) in refluxing acetone gives the pyridinum chloride (III),which is treated with 2-pyridylcarbonyl hydrazide (IV) and triethylamine in methanol yielding the dinitroaniline derivative (V).The cyclization of (V) in refluxing dioxane/water affords the pyridinium ylide (VI),which is finally reduced with NaBH4 in ethanol.