GR-891
Chemical Name: 5-Fluoro-1-[3-(2-hydroxyethoxy)-1-(isopropoxy)propyl]pyrimidine-2,4(1H,3H)-dione
CAS No. 138969-77-4 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Universidad de Granada (Originator)
合成路线:By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4,hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.
📌 参考资料/链接：
参考文献标题:New uracil derivs.having an anti-tumour activity and related cpds.(N-1 derivs.of 5-substd.-uracile)
文献作者:Campos Rosa,J.; Gallo Mezo,M.A.; Dominguez Senglar,J.F.; Entrena Guadix,A.; Pineda de las Infantas y Villatoro,M.J.; Camacho Quesada,E.; Espinosa Ubeda,A.(Universidad de Granada)
参考来源:WO 9117147
📄 详细内容
合成路线:By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4,hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.
参考文献标题:Diheterocyclanes as synthons for the preparation of novel series of nucleoside and acyclonucleoside analogues
文献作者:Campos,J.; Gomez,J.A.; Trujillo,M.A.; Gallo,M.A.; Espinosa,A.; Marchal,J.A.; Aranega,A.
参考来源:Farmaco 1997,52(5),263
合成路线:By reaction of 5-isopropoxy-1,4-dioxepane (I) with 5-fluorouracil (II) by means of SnCl4,hexamethyldisilazane (HMDS) and trimethylchlorosilane (TCS) in acetonitrile.
参考文献标题:A facile synthetic method for pyrimidine acyclonucleoside analogues from alkoxy-1,4-diheterocycloheptanes
文献作者:Gallo,M.A.; et al.
参考来源:Synlett 1993,(6),389