项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

NM-404

Chemical Name: 2-[Hydroxy[18-(4-iodophenyl)octadecyloxy]phosphinyloxy]-N,N,N-trimethylethanaminium inner salt
CAS No. 208986-26-9, 208986-35-0 ([125I]-labelled)
项目整合开发状态: Preclinical
项目研究机构: ...
参考文献标题:Radioiodinated phospholipid ether analogs and methods of using the same
文献作者:Weichert,J.P.; Rampy,M.A.; Counsell,R.E.; Longino,M.A.; Pinchuk,A.N.(University of Michigan)
参考来源:WO 9824480

新产品编号:332729

Chemical Name: trifluoromethanesulfonic acid 2-[4-[3-(1H-indol-3-yl)-2(E)-propenoylamino]butyl]-1,2,3,4-tetrahydro-7-isoquinolinyl ester; 3-(1H-Indol-3-yl)-N-[4-[7-(trifluoromethylsulfonyloxy)-1,2,3,4...
参考文献标题:Tetrahydroisoquinoline derivs.and their pharmaceutical use
文献作者:Nash,D.J.; Stemp,G.(SmithKline Beecham plc)
参考来源:EP 0922035; WO 9806699

CT-5269(diHCl), CT-5269

Chemical Name: N-[3-[2-(Diethylamino)ethoxy]-4,5-dimethoxyphenyl]-9-methoxy-6,6-dimethyl-5,6-dihydrobenzo[h]quinazolin-2-amine
CAS No. 209740-39-6 (diHCl)
项目整合开发状态: Biological Testing
项目研究机构:...
参考文献标题:Fused polycyclic 2-aminopyrimidine derivs.,their
文献作者:Moffat,D.F.C.; Davis,J.M.; Batchelor,M.J.; Davis,P.D.(Celltech Chiroscience plc)
参考来源:EP 0946523; US 6057329; WO 9828281

CGP-62198A

Chemical Name: (2S,4S,5S,7S)-N-[7-[[2-(1-Acetyl-4-piperidinyl)ethyl]carbamoyl]-4-amino-5-hydroxy-2-isopropyl-8-methylnonyl]-2-(4-methoxybutoxy)benzamide; (2S,4S,5S,7S)-N-[2-(1-Acetylpiperidin-4-yl)eth...
参考文献标题:Aromatically substituted omega -amino-alkanoic acid amides and alkanoic acid diamides
文献作者:Maibaum,J.K.; et al.(Novartis AG)
参考来源:CA 2164571; EP 0716077

CT-5276-00, CT-5276

Chemical Name: N-[4-[2-(Diethylamino)ethoxy]-3,5-dimethoxyphenyl]-9-methoxy-6,6-dimethyl-5,6-dihydrobenzo[h]quinazolin-2-amine
CAS No. 209740-42-1
项目整合开发状态: Biological Testing
项目研究机构: Celltec...
参考文献标题:Fused polycyclic 2-aminopyrimidine derivs.,their
文献作者:Moffat,D.F.C.; Davis,J.M.; Batchelor,M.J.; Davis,P.D.(Celltech Chiroscience plc)
参考来源:EP 0946523; US 6057329; WO 9828281

120-1032

Chemical Name: 2-[1-(2-Amino-2-oxoethyl)-3-benzyl-2-ethylindolizin-8-yloxy]acetic acid
CAS No. 177556-87-5
项目整合开发状态: Biological Testing
项目研究机构: Shionogi (Originator)
合成路线:The hydrogenation...
参考文献标题:Indolizine sPLA2 inhibitors
文献作者:Dillard,R.D.; Hagishita,S.; Ohtani,M.(Eli Lilly and Company; Shionogi & Co.Ltd.)
参考来源:EP 0772596; JP 1998505584; WO 9603383

SB-242784

Chemical Name: (2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pentadienamide
CAS No. 201929-00-2, 201929-01-3 (E,E-isomer)
项目整合开发状态: Preclinical
...
参考文献标题:Indole derivs.for the treatment of osteoporosis
文献作者:Farina,C.; Nadler,G.M.M.G.; Gagliardi,S.(GlaxoSmithKline SpA)
参考来源:US 2002173659

VUF-K-8707

Chemical Name: 7-[3-(Quinazolin-2-ylmethoxy)benzyloxy]-3,4-dihydro-2H-1,4-benzothiazin-3-one
CAS No. 198012-72-5
项目整合开发状态: Biological Testing
项目研究机构: Kowa (Originator), Vrije Universiteit (Or...
参考文献标题:Heteroaryl substd.phenylene derivs.,their preparation and their use a leukotriene receptor antagonists
文献作者:Timmerman,H.; Zhang,M.; Onogi,K.; Tamura,M.; Toma,T.; Wada,Y.(Kowa Co.,Ltd.)
参考来源:EP 0799826; JP 1997323975; US 5756518; US 5885987; US 6011033

VUF-K-9015

Chemical Name: 7-[3-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-ylmethoxy]benzyloxy]-3,4-dihydro-2H-1,4-benzothiazin-3-one
CAS No. 198012-83-8
项目整合开发状态: Biological Testing
项目研究机构: Kowa (Originator),...
参考文献标题:Heteroaryl substd.phenylene derivs.,their preparation and their use a leukotriene receptor antagonists
文献作者:Timmerman,H.; Zhang,M.; Onogi,K.; Tamura,M.; Toma,T.; Wada,Y.(Kowa Co.,Ltd.)
参考来源:EP 0799826; JP 1997323975; US 5756518; US 5885987; US 6011033

F-12682

Chemical Name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-4-(2-phenylethyl)piperazine-1-carboxamide
CAS No. 194942-63-7
项目整合开发状态: Preclinical
项目研究机构: Pierre Fabre (Originator)
合成路线:By ...
参考文献标题:Novel aromatic piperazines derived from substd.cycloazanes,method for preparing same,pharmaceutical compsns.,and use thereof as drugs
文献作者:Jorand-Lebrun,C.; Pauwels,P.; Chopin,P.; Marien,M.; Halazy,S.(Pierre Fabre M閐icament)
参考来源:JP 2000505795; WO 9728141