F-12682
Chemical Name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-4-(2-phenylethyl)piperazine-1-carboxamide
CAS No. 194942-63-7
项目整合开发状态: Preclinical
项目研究机构: Pierre Fabre (Originator)
合成路线:By condensation of 1-(2-phenylethyl)piperazine (I) with 4-methoxy-3-(4-methyl-1-piperazinyl)aniline (II) and triphosgene by means of triethylamine in dichloromethane.
📌 参考资料/链接：
参考文献标题:Novel aromatic piperazines derived from substd.cycloazanes,method for preparing same,pharmaceutical compsns.,and use thereof as drugs
文献作者:Jorand-Lebrun,C.; Pauwels,P.; Chopin,P.; Marien,M.; Halazy,S.(Pierre Fabre M閐icament)
参考来源:JP 2000505795; WO 9728141
📄 详细内容
合成路线:By condensation of 1-(2-phenylethyl)piperazine (I) with 4-methoxy-3-(4-methyl-1-piperazinyl)aniline (II) and triphosgene by means of triethylamine in dichloromethane.
参考文献标题:Synthesis and pharmacological studies of a new 5HT1B/1D receptors inverse agonist
文献作者:Jorand-Lebrun,C.; et al.
参考来源:15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998,Edinburgh) 1998,Abst P.162