NM-404

Chemical Name: 2-[Hydroxy[18-(4-iodophenyl)octadecyloxy]phosphinyloxy]-N,N,N-trimethylethanaminium inner salt
CAS No. 208986-26-9, 208986-35-0 ([125I]-labelled)
项目整合开发状态: Preclinical
项目研究机构: University of Michigan (Originator)
合成路线:Iodophenylpentadecanoic acid (I) was reduced to the corresponding alcohol (II) with borane in THF and then converted to the tosylate (III).Treatment of 3-(benzyloxy)propanol (IV) with CBr4 and PPh3 afforded bromide (V).This was treated with Mg in THF and the resulting Grignard reagent was coupled with tosylate (III) in the presence of Li2CuCl4 to provide octadecyl benzyl ether (VI),which was cleaved to the aryl octadecanol (VII) using AlCl3 and anisole.Reaction of alcohol (VII) with phospholane (VIII),followed by condensation with trimethylamine then furnished the title compound.