项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

S-18327

Chemical Name: 1-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-3-phenylimidazolidin-2-one
CAS No. 200398-40-9
项目整合开发状态: Phase I
项目研究机构: Servier (Originator)
合成路线:Condensation...
参考文献标题:3-(Piperid-4-yl)-1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole cpds.
文献作者:Audinot,V.; Millan,M.; Brocco,M.; Peglion,J.-L.(ADIR et Cie.)
参考来源:EP 0811622; FR 2749304; US 5780474

Amelubant, BIIL-284

Chemical Name: N-(Ethoxycarbonyl)-4-[3-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxymethyl]benzyloxy]benzenecarboximidamide
CAS No. 346735-24-8
项目整合开发状态: Phase II
项目研究机构: Boehringer Ingelheim...
参考文献标题:Substd.benzamidines,their production and their use as medicaments
文献作者:Anderskewitz,R.; Schromm,K.; Renth,E.-O.; Birke,F.; F黦ner,A.; Heuer,H.; Meade,C.(Boehringer Ingelheim GmbH)
参考来源:DE 4424713; EP 0770059; JP 1998502645; US 5731332; WO 9602497

Y-40079

Chemical Name: 2-[2-[2-[5-Amino-2-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]acetamido]-3-phenylpropionyl]benzoxazole-5-carboxylic acid methyl ester
CAS No. 207235-51-6
项目整合开发状态: Preclini...
参考文献标题:Novel heterocyclic amide cpds.and medicinal uses thereof
文献作者:Akahoshi,F.; Ashimori,A.; Yoshimura,T.; Eda,M.; Sakashita,H.; Nakajima,M.; Imada,T.(Welfide Corporation)
参考来源:EP 0940400; US 6080738; WO 9818794

RGH-1756

Chemical Name: 6-[4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butoxy]phenyl]imidazo[2,1-b]thiazole
CAS No. 207277-37-0
项目整合开发状态: Preclinical
项目研究机构: Gedeon Richter (Originator)
合成路线:By condens...
参考文献标题:2-Methoxyphenylpiperazine derivs.
文献作者:Laszlovszky,I.; Dom醤y,G.; Ferenczy,G.; Sz醤tay,C.Jr.; Thuroczyn?K醠m醤,E.; Lapis,E.; Trischler,F.; Heged鷖,B.; Auth,F.; Csejtei,M.; K醨p醫i,E.; Kiss,B.; Laszy,J.; Pellioniszn?Par骳zai,M.; Sarkadi,A.; Szab? S.(Gedeon Richter Ltd.)
参考来源:EP 0935599; US 6103724; WO 9818797

ALX-0646(free base), ALX-646CL

Chemical Name: N,N-Dimethyl-N-[2-[5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-3-yl]ethyl]amine dihydrochloride
CAS No. 251967-66-5, 208464-98-6 (benzoate), 208464-67-9 (free base), 208464-...
参考文献标题:5-Cyclo indole cpds.as 5-HT1D receptor ligands
文献作者:Slassi,A.; Edwards,L.; Meng,Q.; Rakhit,S.(NPS Allelix Corp.)
参考来源:EP 0944595; JP 2001504501; WO 9823587

SB-247464

Chemical Name: cis-2,5-Bis(1H-benzimidazol-2-ylimino)-3a,6a-bis(2-pyridyl)perhydroimidazo[4,5-d]imidazole
CAS No. 212077-57-1, 199854-53-0 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Gla...
参考文献标题:Non-peptide G-CSF mimetics
文献作者:Luengo,J.I.; Chan,J.A.; Breen,A.L.(SmithKline Beecham plc)
参考来源:EP 0920314; WO 9744033

AU-130

Chemical Name: 4-(4-Amino-5-chloro-2-methoxybenzamido)piperidine-1-acetic acid
CAS No. 145727-25-9 (mono HCl salt)
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:4-Acetylamino-2-me...
参考文献标题:Benzamide deriv.
文献作者:Ito,Y.; Kato,H.; Yasuda,S.; Iwasaki,N.; Nishino,H.; Takeshita,M.(Hokuriku Seiyaku Co.,Ltd.)
参考来源:EP 0640601; US 5395832; US 5500422; WO 9214705

CL-309623

Chemical Name: (E)-2,2'-(1,2-Ethenediyl)bis[5-[4,6-bis[3-[bis(3-amino-3-oxopropyl)aminosulfonyl]phenylamino]-1,3,5-triazin-2-ylamino]dibenzenesulfonic acid disodium salt
CAS No. 197365-86-9, 197366...
参考文献标题:Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivs.,their preparation and their use as antiviral agents
文献作者:Ding,W.-D.; Gluzman,Y.; Morin,J.E.; Mitsner,B.; Ellestad,G.A.; Nikitenko,A.A.; O'Hara,B.M.; Larocque,J.P.; Raifeld,Y.E.(American Cyanamid Co.)
参考来源:CA 2197393; EP 0795549; JP 1997309882; US 5852015

RFI-641(free acid), CL-387626

Chemical Name: 4,4'-Bis[4,6-bis[3-[bis(3-amino-3-oxopropyl)aminosulfonyl]phenylamino]-1,3,5-triazin-2-ylamino][1,1'-biphenyl]-2,2'-disulfonic acid disodium salt
CAS No. 197365-88-1, 197366-31-7 (fr...
参考文献标题:Inhibition of respiratory syncytial virus by a new class of chemotherapeutic agents
文献作者:Aulabaugh,A.; et al.
参考来源:Drugs Fut 2000,25(3),287

(S)-LG-120746, LG-120746-(S)

Chemical Name: (S)-5-(3-Chlorophenyl)-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-[1]benzopyrano[3,4-f]quinoline
CAS No. 179895-46-6 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Ligand (Origi...
参考文献标题:Preparation,resolution,and biological evaluation of 5-aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: Potent,orally active,nonsteroidal progesterone receptor agonists
文献作者:Edwards,J.P.; Zhi,L.; Pooley,C.L.F.; Tegley,C.M.; West,S.J.; Wang,M.-W.; Gottardis,M.M.; Pathirana,C.; Schrader,W.T.; Jones,T.K.
参考来源:J Med Chem 1998,41(15),2779