Amelubant, BIIL-284

Chemical Name: N-(Ethoxycarbonyl)-4-[3-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxymethyl]benzyloxy]benzenecarboximidamide
CAS No. 346735-24-8
项目整合开发状态: Phase II
项目研究机构: Boehringer Ingelheim (Orphan Drug), Boehringer Ingelheim (Originator)
合成路线:Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine.Further hydrogenation in the presence of Raney-nickel provided amidine (III),which was finally condensed with ethyl chloroformate to yield the title compound.

合成路线:Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine.Further hydrogenation in the presence of Raney-nickel provided the target amidine.