项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:100175

Chemical Name: 3-[6-(4-Chlorophenylsulfonamido)-3-(3-pyridylmethyl)-5,6,7,8-tetrahydronaphthalen-1-yl]propionic acid
CAS No. 165537-81-5
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
...
参考文献标题:1,2,3,4-Tetrahydronaphthalene,chroman and thiochroman derivs.as antithrombotic agents
文献作者:Lavielle,G.; Dubuffet,T.; Muller,O.; Laubie,M.; Verbeuren,T.; Simonet,S.; Descombes,J.-J.(ADIR et Cie.)
参考来源:CA 2118102; EP 0648741; FR 2711139; JP 1995188155

R-94138

Chemical Name: 3(R)-[3(S)-(N-Methylcarbamoyl)hexahydropyridazin-2-ylcarbonyl]dodecanehydroxamic acid
CAS No. 163388-94-1
项目整合开发状态: Preclinical
项目研究机构: Sankyo (Originator)
合成路线:Reductive cl...
参考文献标题:Collagenase inhibitor agents
文献作者:Sugimura,M.; Tamaki,K.; Tanzawa,K.; Kobayashi,T.(Sankyo Co.,Ltd.)
参考来源:JP 1995002797

HS-378

Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-4,5alpha-epoxy-14-ethoxy-3-hydroxy-5-methylindolo[2',3':6,7]morphinan hydrochloride
CAS No. 173782-64-4, 188246-02-8 (free base)
项目整合开发状态: Pre...
参考文献标题:New antagonist cpds.
文献作者:Schmidhammer,H.(AstraZeneca plc)
参考来源:EP 0759922; JP 1998500131; US 6136817; WO 9531463

Ro-25-6760

Chemical Name: 26,26,26,27,27,27-Hexafluoro-1alpha,25-dihydroxy-16,17,23,23,24,24-hexadehydro-19-norvitamin D3; (1alpha,3beta,7E)-26,26,26,27,27,27-Hexafluoro-19-nor-9,10-secocholesta-5,7,16-trien-23-...
参考文献标题:Vitamin D3 fluorinated analogs
文献作者:Baggiolini,B.J.; Shiuey,S.-J.; Uskokovic,M.R.(F.Hoffmann-La Roche AG)
参考来源:US 5451574; US 5753638

YM-47141

Chemical Name: [3R-(3alpha,6beta,9beta,17alpha,18alpha)]-6-(Carbamoylmethyl)-9,14-diisobutyl-3,18-dimethyl-17-(phenylacetyl-L-phenylalanyl-L-threonylamino)-1-oxa-4,7,10,15-tetraazacyclooctadecane-2,5,...
参考文献标题:Total syntheses of depsipeptide elastase inhibitor
文献作者:Wasserman,H.H.; et al.
参考来源:J Am Chem Soc 1999,121(6),1401

Tetraplatin tetranitrate, BBR-3464

Chemical Name: (trans,trans,trans)-Bis-mu-(hexane-1,6-diamine)-mu-[diammineplatinum(II)]bis[diammine(chloro)platinum(II)] tetranitrate; trans-[Bis[trans-diamminechloroplatinum(mu-hexane-1,6-diamine)]]...
参考文献标题:Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compsns.containing them
文献作者:Valsecchi,M.; Conti,M.; Del Greco,L.; Gubatti,C.; Menta,E.; Giuliani,F.; Manzotti,C.; Spinelli,S.; Farrell,N.(Roche Diagnostics GmbH)
参考来源:EP 0753000; JP 1997506633; US 5744497; WO 9526968

OT-7100

Chemical Name: 5-Butyl-7-(3,4,5-trimethoxybenzamido)pyrazolo[1,5-a]pyrimidine; N-(5-Butylpyrazolo[1,5-a]pyrimidin-7-yl)-3,4,5-trimethoxybenzamide
CAS No. 174858-27-6
项目整合开发状态: Preclinical
项目研...
参考文献标题:Pyrazolo[1,5-a]pyrimidine deriv.
文献作者:Shoji,Y.; Yasuda,T.; Inoue,M.; Okamura,T.; Hashimoto,K.; Ohara,M.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0714898; JP 1996310951; JP 1996311068; US 5707997; WO 9535298

BMS-184000

Chemical Name: 2,3-Di-O-benzoyl-1-O-[3(R)-benzoyloxy-2(S)-(hexadecanamido)-4(E)-octadecenyl]-4,6-di-O-sulfo-alpha-D-galactopyranose disodium salt
CAS No. 172146-75-7
项目整合开发状态: Preclinical
项目研...
参考文献标题:Sulfated beta-glycolipid derivs.as cell adhesion inhibitors
文献作者:Banville,J.; Martel,A.; Aruffo,A.A.(Bristol-Myers Squibb Co.)
参考来源:EP 0671406; JP 1995285985; US 5565433

CB-300907

Chemical Name: 4(R)-[N-[4-[N-(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(2-propynyl)amino]benzoyl]-L-gamma-glutamylamino]-4-(1H-tetrazol-5-yl)butyric acid; N5-[3-Carboxy-1(R...
参考文献标题:Anti-cancer cpds.containing cyclopentaquinazoline ring
文献作者:Bavetsias,V.; Boyle,F.T.; Hennequin,L.F.A.; Marriott,J.H.(AstraZeneca plc; BTG plc)
参考来源:EP 0758328; GB 2290082; JP 1997512812; US 5747499; WO 9530673

新产品编号:370697

Chemical Name: 5-Chloro-N-(1-ethyl-4-methylperhydro-1,4-diazepin-6(R)-yl]-2-methoxy-4-(methylamino)benzamide dimaleate
CAS No. 206434-63-1, 206434-53-9 (free base), 206434-54-0 (free base, (S)-isom...
参考文献标题:Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives,novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist
文献作者:Hirokawa,Y.; Harada,H.; Yoshikawa,T.; Yoshida,N.; Kato,S.
参考来源:Chem Pharm Bull 2002,50(7),941