OT-7100

Chemical Name: 5-Butyl-7-(3,4,5-trimethoxybenzamido)pyrazolo[1,5-a]pyrimidine; N-(5-Butylpyrazolo[1,5-a]pyrimidin-7-yl)-3,4,5-trimethoxybenzamide
CAS No. 174858-27-6
项目整合开发状态: Preclinical
项目研究机构: Otsuka (Originator)
合成路线:5-Butyl-7-hydroxypyrazolo[1,5-a]pyrimidine (III) was prepared by condensation of 3-aminopyrazole (I) with methyl 3-oxoheptanoate (II) in refluxing toluene.Treatment of (III) with POCl3 in the presence of Et3N furnished the 7-chloro derivative (IV),which was then heated with aqueous ammonia in a sealed tube to afford the amino pyrazolopyrimidine (V).Finally,acylation of amine (V) with 3,4,5-trimethoxybenzoyl chloride (VI) led to the title amide.