Tetraplatin tetranitrate, BBR-3464
Chemical Name: (trans,trans,trans)-Bis-mu-(hexane-1,6-diamine)-mu-[diammineplatinum(II)]bis[diammine(chloro)platinum(II)] tetranitrate; trans-[Bis[trans-diamminechloroplatinum(mu-hexane-1,6-diamine)]]diammineplatinum tetranitrate; Hexaamminedichlorobis[mu-(1,6-hexanediamine-kappaN:kappaN')]triplatinum(4+) tetranitrate
CAS No. 172903-00-3, 172902-99-7 (cation)
项目整合开发状态: Phase II
项目研究机构: Roche (Originator), Novuspharma (Licensee)
合成路线:The condensation of platinum complex (I) with N-Boc-hexane-1,6-diamine (II) by means of 1 mole of AgNO3 in DMF gives the platinum complex (III),which is deprotected with HCl in methanol/ethanol to yield complex (IV).Finally,platinum complex (I) is condensed with two moles of complex (IV) by means of two moles of AgNO3 in DMF to afford the target trinuclear complex.
📌 参考资料/链接：
参考文献标题:Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compsns.containing them
文献作者:Valsecchi,M.; Conti,M.; Del Greco,L.; Gubatti,C.; Menta,E.; Giuliani,F.; Manzotti,C.; Spinelli,S.; Farrell,N.(Roche Diagnostics GmbH)
参考来源:EP 0753000; JP 1997506633; US 5744497; WO 9526968
📄 详细内容
合成路线:The condensation of platinum complex (I) with N-Boc-hexane-1,6-diamine (II) by means of 1 mole of AgNO3 in DMF gives the platinum complex (III),which is deprotected with HCl in methanol/ethanol to yield complex (IV).Finally,platinum complex (I) is condensed with two moles of complex (IV) by means of two moles of AgNO3 in DMF to afford the target trinuclear complex.
参考文献标题:Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compsns.containing them
文献作者:Valsecchi,M.; Pavesi,P.; Bugatti,C.; Menta,E.; Giuliani,F.C.; Manzotti,C.; Spinelli,S.; Farrell,N.(Roche Diagnostics GmbH)
参考来源:EP 0793667; JP 1998509159; WO 9616068
产品链接: CAS No. 172903-00-3›› 产品链接: CAS No.172902-99-7››