项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Propentofylline, HWA-285, Viviq, Hextol

普罗潘非林Chemical Name: 1-(5'-Oxohexyl)-3-methyl-7-propylxanthine; 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione; 3-Methyl-1-(5-oxohexyl)-7-propyl-1,2,3,6-tetrahydropurine-2,6-dione
...
参考文献标题:Propentofylline
文献作者:Thorpe,P.J.; Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1982,7(2),119

Prucalopride, R-093877, R-93877, Resolor

普芦卡必利盐酸普卡必利Chemical Name: 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydrobenzofuran-7-carboxamide
CAS No. 179474-81-8, 179474-84-1 (monoHBr salt), 179474-80-7 (monoHCl)
项目整合开发...
参考文献标题:Enterokinetic benzamide
文献作者:Hendrickx,M.-L.; Van Daele,K.G.C.E.; Van Daele,P.J.V.; Van Daele,G.K.L.(Janssen Pharmaceutica NV)
参考来源:EP 0807110; JP 1997512832; US 5854260; WO 9616060

Prinomastat, AG-3362(maleate), AG-3354(HCl), AG-3340

普马司他Chemical Name: 2,2-Dimethyl-4-[4-(4-pyridyloxy)phenylsulfonyl]perhydro-1,4-thiazine-3(S)-carbohydroxamic acid; N-Hydroxy-2,2-dimethyl-4-[4-(4-pyridinyloxy)phenylsulfonyl]thiomorpholine-3(S)-carbox...
参考文献标题:Metalloproteinase inhibitors,pharmaceutical compsns.containing them and their pharmaceutical uses,and methods and intermediates useful for their preparation
文献作者:Zook,S.E.; Dagnino,R.Jr.; Deason,M.E.; Bender,S.L.; Melnick,M.J.(Agouron Pharmaceuticals,Inc.)
参考来源:EP 0874830; JP 2000502330; WO 9720824

Pumafentrine, BY-343

普马芬群Chemical Name: (-)-4-[(4aR*,10bS*)-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c]-1,6-naphthyridin-6-yl]-N,N-diisopropylbenzamide
CAS No. 207993-12-2, 207992-97-0 (monoHCl)
项目整...
参考文献标题:Benzonaphthyridines as bronchial therapeutics
文献作者:Gutterer,B.; Amschler,H.; Ulrich,W.-R.; Martin,T.; B鋜,T.; Hatzelmann,A.; Sanders,K.; Beume,R.; Boss,H.; H鋐ner,D.; Kley,H.-P.; Goebel,K.-J.(Altana Pharma Deutschland GmbH )
参考来源:EP 0937074; JP 2001503442; US 6008215; WO 9821208

Prizidilol, SKF-92657

普齐地洛Chemical Name: 1-(tert-Butylamino)-3-[2-(6-hydrazinopyridazin-3-yl)phenoxy]propan-2-ol
CAS No. 59010-44-5, 59010-45-6 (sulfate salt(2:1))
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The est...
参考文献标题:
文献作者:Coates,W.J.; et al.
参考来源:BE 830158; DE 2527066; JP 7613782; NL 7507267

(+)-Fluprostenol isopropyl ester, Travoprost, AL-6221, Travatan

曲伏前列腺素Chemical Name: 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[3(R)-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1(E)-butenyl]cyclopentyl]-5(Z)-heptenoic acid isopropyl ester; (+)-16-[3-(Trifluoromethoxy)phenoxy]-1...
参考文献标题:Use of cloprostenol,fluprostenol and their analogues for the manufacture of a medicament for the treatment of glaucoma and ocular hypertension
文献作者:Klimko,P.G.; Bishop,J.A.; DeSantis,L.Jr.; Sallee,V.L.(Alcon Laboratories,Inc.)
参考来源:EP 0639563; JP 1995165703; JP 1998182465; US 5665773

Trovafloxacin mesylate, Trovafloxacin mesilate, CP-99219-27, CP-99219, Turvel, Trovan

曲伐沙星甲磺酸盐聚苯乙烯磺酸钙 Chemical Name: (1alpha,5alpha,6alpha)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid monomethanesulfonat...
参考文献标题:Azabicyclo quinolone carboxylic acids
文献作者:Brighty,K.E.(Pfizer Inc.)
参考来源:AU 9161042; EP 0413455; JP 1991086875; US 5164402; WO 9102526

Treprostinil sodium, Uniprost, LRX-15, U-62840, UT-15, BW-15AU, 15AU81, Remodulin

曲前列尼尔钠曲前列尼尔 Chemical Name: 9-Deoxy-3,7-(1',3'-interphenylene)-2',9-methano-3-oxa-4,5,6-trinor-13,14-dihydroprostaglandin F1 sodium salt; (1R,2R,3aS,9aS)-2-[2-Hydroxy-1-[3(S)-hydroxyoctyl]-2,3,3a,4,9,...
参考文献标题:Carbacyclin analogues
文献作者:Aristoff,P.A.(Pharmacia Corp.)
参考来源:EP 0159784; JP 1985208936; US 4683330

Trepipam, Trimopam(formerly), Sch-12679(maleate)

曲匹泮Chemical Name: (+)-2,3,4,5-Tetrahydro-7,8-dimethoxy-3-methyl-1-phenyl-1H-3-benzazepine
CAS No. 56030-50-3, 39624-66-3 (maleate)
项目整合开发状态: Biological Testing
项目研究机构: Schering-Plough (Origin...
参考文献标题:Novel benzazepines
文献作者:Walter,L.A.; Chang,W.K.(Schering Corp.)
参考来源:US 3393192

Troquidazole, EGIS-4136

曲喹达佐Chemical Name: N-(3-Nitro-4-quinolinyl)-4-morpholinecarboxamidine
CAS No. 108001-60-1, 108001-71-4 (HCl)
项目整合开发状态: Preclinical
项目研究机构: Egis (Originator)
合成路线:Nitroacetaldehyde oxime (I...
参考文献标题:N-(3-Nitroquinolin-4-yl)guanidine derivatives as radiosensitizers.(EGIS Pharm.,Ltd.)
文献作者:Ber閚yi,E.; Varga,L.; Pallos,L.; Pet鯿z,L.; Lad醤yi,L.; T鰉pe,P.; Hartai,E.; Kov醕s,A.(Egis Pharmaceuticals Ltd.)
参考来源:BE 0904864; CH 668069; ES 8707231; GB 2176185; JP 1987048668; US 4652562