Prucalopride, R-093877, R-93877, Resolor
普芦卡必利盐酸普卡必利Chemical Name: 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydrobenzofuran-7-carboxamide
CAS No. 179474-81-8, 179474-84-1 (monoHBr salt), 179474-80-7 (monoHCl)
项目整合开发状态: Phase III
项目研究机构: Janssen (Originator)
合成路线:Prucalopride is synthesized by condensation of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid (I) with 1-(3-methoxypropyl)piperidin-4-amine (II) by means of ethyl chloroformate and triethylamine in chloroform.
📌 参考资料/链接：
参考文献标题:Enterokinetic benzamide
文献作者:Hendrickx,M.-L.; Van Daele,K.G.C.E.; Van Daele,P.J.V.; Van Daele,G.K.L.(Janssen Pharmaceutica NV)
参考来源:EP 0807110; JP 1997512832; US 5854260; WO 9616060
📄 详细内容
合成路线:Prucalopride is synthesized by condensation of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid (I) with 1-(3-methoxypropyl)piperidin-4-amine (II) by means of ethyl chloroformate and triethylamine in chloroform.
参考文献标题:Prucalopride
文献作者:Castar,J.; Rabasseda,X.
参考来源:Drugs Fut 1999,24(7),729