Pumafentrine, BY-343

普马芬群Chemical Name: (-)-4-[(4aR*,10bS*)-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c]-1,6-naphthyridin-6-yl]-N,N-diisopropylbenzamide
CAS No. 207993-12-2, 207992-97-0 (monoHCl)
项目整合开发状态: Discontinued
项目研究机构: Altana Pharma (Originator)
合成路线:The reaction of terephthalic acid monomethyl ester (I) with SOCl2 in dichloromethane gives the acyl chloride (II),which is condensed with 3-(3-ethoxy-4-methoxyphenyl)-1-methylpiperidin-4-amine (III) by means of TEA in dichloromethane,yielding the corresponding amide (IV).The cyclization of (IV) by means of POCl3 in refluxing acetonitrile affords the benzo-naphthyridine (V),which is treated with diisopropylamine in methanol to provide the target diisopropyl carboxamide.