其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Benzofuran CAS Registry Number: 271-89-6 苯并呋喃

Additional Names: Coumarone; cumarone
Percent Composition: C 81.34%, H 5.12%, O 13.54%
Literature References: Constituent of coal tar, q.v. Isoln from coal tar oils: Kraemer, Spilker, Ber. 23, 78 (1890); 33, 2261 (1900); Breston, Gauger, Am. Gas Assoc. Proc. 28, 492 (1946). Synthesis by heating phenoxyacetaldehyde with zinc chloride and acetic acid: Stoermer, Ber. 30, 1703 (1897); Ann. 312, 261 (1900). Review of toxicology and human exposure: Toxicological Profile for 2,3-Benzofuran (PB93-110666, 1992) 95 pp.

Benzo[e]pyrene CAS Registry Number: 192-97-2 苯并[e]芘

Additional Names: 1,2-Benzpyrene; 4,5-benzpyrene
Percent Composition: C 95.21%, H 4.79%
Literature References: Constituent of coal tar, q.v. Isoln: Cook et al., J. Chem. Soc. 1933, 396. Synthesis: Cook, Hewett, ibid. 398; Clar, Ber. 76, 609 (1943); Buchta, Kröger, Ann. 705, 190 (1967). NMR spectra: Cobb, Memory, J. Chem. Phys. 47, 2020 (1967). Review: Clar, Polycyclic Hydrocarbons Vol. 2, (Academic Press, New York, 1964) p 127. Review of toxicology and human exposure: Toxicological Profile for Polycyclic Aromatic Hydrocarbons (PB95-264370, 1995) 487 pp.

Skatole CAS Registry Number: 83-34-1 3-甲基吲哚

CAS Name: 3-Methyl-1H-indole
Percent Composition: C 82.41%, H 6.92%, N 10.68%
Literature References: Constituent of feces, beetroot, nectandra wood, and coal tar. Obtained by fusing egg albumin with KOH. Toxicity data: Bin-Ichi, Tohoku J. Exp. Med. 25, 407 (1935).

Alliin CAS Registry Number: 556-27-4 蒜氨酸; 蒜碱

CAS Name: 3-[(S)-2-Propenylsulfinyl]-L-alanine
Additional Names: 3-((S)-allylsulfinyl)-L-alanine; S-allyl-L-cysteine sulfoxide
Percent Composition: C 40.66%, H 6.26%, N 7.90%, O 27.08%, S 18...
Literature References: Constituent of garlic, Allium sativum L., Liliaceae; also found in other Allium spp. Degraded by alliinase to produce the garlic flavor component, allicin, q.v. Isoln: Stoll, Seebeck, Helv. Chim. Acta 31, 189 (1948). Synthesis: eidem, Experientia 6, 330 (1950); Helv. Chim. Acta 34, 481 (1951). Extraction from Allium plants and LC determn: E. Mochizuki et al., J. AOAC Int. 80, 1052 (1997). In vitro immunomodulatory effects on peripheral blood cells: H. Salman et al., Int. J. Immunopharmacol. 21, 589 (1999). Biosynthesis in garlic tissue cultures: J. Hughes et al., Phytochemistry 66, 187 (2005).

Porphyrillic Acid CAS Registry Number: 129-65-7 1,3-二氢-4,10-二羟基-8-甲基-3-氧杂-苯并[4,5]呋喃[3,2-e]异苯丙呋喃-7-羧酸

CAS Name: 1,3-Dihydro-4,10-dihydroxy-8-methyl-3-oxoisobenzofuro[5,4-b]benzofuran-7-carboxylic acid
Additional Names: 1,7-dihydroxy-9-hydroxymethyl-3-methyl-4,8-dibenzofurandicarboxylic acid (8,...
Literature References: Constituent of lichens. Isoln from Haematomma coccineum Dicks., Lecanoreae, and structure studies: Wachtmeister, Acta Chem. Scand. 8, 1433 (1954); 10, 1404 (1956).

Urothion CAS Registry Number: 19295-31-9 2-氨基-7-[(1R)-1,2-二羟基乙基]-6-(甲硫基)-噻吩并[3,2-g]蝶啶-4(1H)-酮

CAS Name: 2-Amino-7-(1,2-dihydroxyethyl)-6-(methylthio)thieno[3,2-g]pteridin-4(3H)-one
Percent Composition: C 40.61%, H 3.41%, N 21.52%, O 14.75%, S 19.71%
Literature References: Constituent of normal human urine: Koschara, Z. Physiol. Chem. 277, 284 (1943). Structure: Tschesche et al., Ber. 88, 1251 (1955). Revised structure: Goto et al., Tetrahedron Lett. 1967, 4507; eidem, J. Biochem. (Tokyo) 65, 611 (1969). Synthesis: Sakurai, Goto, Tetrahedron Lett. 1968, 2941; eidem, J. Biochem. (Tokyo) 65, 755 (1969).

Cytidine CAS Registry Number: 65-46-3 胞嘧啶核苷

Additional Names: 4-Amino-1-b-D-ribofuranosyl-2-(1H)-pyrimidinone; cytosine riboside; 1-b-D-ribofuranosylcytosine
Percent Composition: C 44.44%, H 5.39%, N 17.28%, O 32.89%
Literature References: Constituent of nucleic acids. Isoln from yeast nucleic acid: Levene, Jacobs, Ber. 43, 3154 (1910); Levene, La Forge, ibid. 45, 608 (1912). Sepn from other nucleosides by ion-exchange chromatography: Cohn in Chargaff-Davidson, The Nucleic Acids vol. I (New York, 1955) p 211. Synthesis: Howard et al., J. Chem. Soc. 1947, 1052. Crystal structure: Furberg et al., Acta Crystallogr. 18, 313 (1965). Review: Basic Principles in Nucleic Acid Chemistry vol. 1, P. O. P. Ts'o, Ed. (Academic Press, New York, 1974) passim.

Sesamolin CAS Registry Number: 526-07-8 芝麻林素

CAS Name: 5-[4-(1,3-Benzodioxolol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole
Additional Names: tetrahydro-1-[3,4-(methylenedioxy)phenoxy]-4-[3,4-(methylenedioxy)phenyl]-1H...
Literature References: Constituent of sesame seeds, the seeds of Sesamum indicum L., Pedaliaceae. Isoln: Canzoneri, Perciabosco, Gazz. Chim. Ital. 33, II, 253 (1907). Structure and synthesis: J. Boseken, W. D. Cohen, Rec. Trav. Chim. 55, 815 (1936); E. Haslam, R. D. Haworth, J. Chem. Soc. 1955, 827. Stereochemistry: E. Haslam, ibid. 1970, 2332.

Albizziin CAS Registry Number: 1483-07-4 L-脲基丙氨酸

CAS Name: 3-[(Aminocarbonyl)amino]-L-alanine
Additional Names: 2-amino-3-ureidopropionic acid
Percent Composition: C 32.65%, H 6.17%, N 28.56%, O 32.62%
Literature References: Constituent of several plants belonging to the family Mimosaceae. First obtained from the seeds of Albizzia julibrissin Durazz., Mimosaceae: Gmelin et al., Z. Naturforsch. 13b, 252 (1958); Z. Physiol. Chem. 314, 28 (1959). Structure: Kjaer et al., Experientia 15, 253 (1959). Synthesis: Kjaer, Larsen, Acta Chem. Scand. 13, 1565 (1959); Rudinger et al., Collect. Czech. Chem. Commun. 25, 2022 (1960).

Benzyl Cinnamate CAS Registry Number: 103-41-3 肉桂酸苄酯

CAS Name: 3-Phenyl-2-propenoic acid phenylmethyl ester
Additional Names: trans-cinnamic acid benzyl ester; cinnamein
Percent Composition: C 80.65%, H 5.92%, O 13.43%
Literature References: Constituent of storax, Peru and Tolu balsams: Tschirch, Trog, Arch. Pharm. 232, 70 (1894); Tschirch, Oberländer, ibid. 559. Prepn: Volwiler, Vliet, J. Am. Chem. Soc. 43, 1672 (1921); Eliel, Anderson, ibid. 74, 547 (1952); Bender, Zerner, ibid. 84, 2550 (1962). Toxicity study: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).