其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Periplocymarin CAS Registry Number: 32476-67-8 杠柳麻甙

CAS Name: (2,6-Dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl)oxy-5,14-dihydroxy-card-20(22)-enolide
Percent Composition: C 67.39%, H 8.67%, O 23.94%
Literature References: By extracting bark and wood of Periploca graeca L., Asclepiadaceae with 70% alcohol and treating with the enzyme strophanthobiase from seeds of Strophanthus courmonti Sacleux, Apocynaceae: Jacobs, Hoffmann, J. Biol. Chem. 79, 519 (1928); Katz, Reichstein, Pharm. Acta Helv. 19, 231 (1944); from S. hypoleucus Stapf: von Euw, Reichstein, Helv. Chim. Acta 33, 544 (1950); from S. ledienii Stein: Lichti et al., ibid. 39, 1914 (1956); from S. eminii Asch. et Pax.: Zelnik, Schindler, ibid. 40, 2110 (1957). Structure: von Euw, Reichstein, ibid. 31, 883 (1948). Acid hydrolysis yields one mol periplogenin and one mol cymarose, q.q.v.. The cymarose is attached to the hydroxyl group at C-3 of the aglycon.

Phenindione CAS Registry Number: 83-12-5 苯茚二酮

CAS Name: 2-Phenyl-1H-indene-1,3(2H)-dione
Additional Names: 2-phenyl-1,3-indandione; 2-phenyl-1,3-diketohydrindene; PID
Trademarks: Pindione (Lipha); Bindan; Dindevan (Duncan Flockhart); Di...
Literature References: By heating phthalide with benzaldehyde and sodium ethylate soln: Dieckmann, Ber. 47, 1439 (1914).

Coumarin-3-carboxylic Acid CAS Registry Number: 531-81-7 香豆素-3-羧酸

CAS Name: 2-Oxo-2H-1-benzopyran-3-carboxylic acid
Percent Composition: C 63.16%, H 3.18%, O 33.66%
Literature References: By heating salicylaldehyde with malonic acid in glacial acetic acid. Review: Sethna, Shah, Chem. Rev. 36, 1 (1945).

Cymarose CAS Registry Number: 579-04-4

CAS Name: 2,6-Dideoxy-3-O-methyl-ribo-hexose
Additional Names: 3-methyldigitoxose
Percent Composition: C 51.84%, H 8.70%, O 39.46%
Literature References: By hydrolysis of a number of cardiac glycosides from the Apocynaceae family. From Apocynum cannabinum L., A. androsaemifolium L., A. venetum L.: Windaus, Hermanns, Ber. 48, 979 (1915); Trabert, Arzneim.-Forsch. 10, 197 (1960); from Strophanthus kombé Oliv., Periploca graeca L.: Jacobs, Hoffmann, J. Biol. Chem. 67, 609 (1926); 79, 519 (1928); from S. emini Aschers Pax: Lamb, Smith, J. Chem. Soc. 1936 442; also from Castilla elastica Cerv., Moraceae: Adams, Wilkinson, J. Pharm. Pharmacol. 13, 279 (1961). Structure: S. F. Dyke, The Carbohydrates (Interscience, New York, 1960) p 104. Synthesis: Bollinger, Ulrich, Helv. Chim. Acta 35, 93 (1952). Review: R. C. Elderfield, "The Carbohydrate Components of Cardiac Glycosides" in W. W. Pigman, M. L. Wolfrom, Advances in Carbohydrate Chemistry vol. I (Academic Press, New York, 1945) pp 147-173.

Scutellarein CAS Registry Number: 529-53-3 野黄芩素

CAS Name: 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Additional Names: 4',5,6,7-tetrahydroxyflavone; 6-hydroxypelargidenon 1465
Percent Composition: C 62.94%, H 3.52%, O 33.5...
Literature References: By hydrolysis of scutellarin: Molisck, Goldschmidt, Monatsh. Chem. 22, 679 (1901); Marsh, Biochem. J. 59, 58 (1955). From Digitalis lanata Ehrh., Scrophulariaceae: Rangaswami, Rao, Proc. Indian Acad. Sci. 54A, 51 (1961), C.A. 56, 10076f (1962). Structure: Wessely, Moser, Monatsh. Chem. 56, 97 (1930). Synthesis: Sastri, Seshadri, Proc. Indian Acad. Sci. 23A, 262 (1946), C.A. 41, 449a (1947); Zemplén et al., Acta Chim. Acad. Sci. Hung. 16, 445 (1958); Jouanne, Mentzer, C.R. Seances Acad. Sci. Ser. C 263, 1022 (1966).

Hydrastinine CAS Registry Number: 6592-85-4 北美黄连次碱

CAS Name: 5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol
Additional Names: 1-hydroxy-6,7-methylenedioxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
Percent Composition: C 63.75%,...
Literature References: By oxidation of hydrastine: Freund, Will, Ber. 20, 88 (1887). From berberine: Freund, DE 241136 (1910), C.A. 6, 2145 (1912). From cotarnine: Pyman, Remfry, J. Chem. Soc. 101, 1595 (1912); Topchiev, J. Appl. Chem. USSR 6, 529 (1933). From formylhomopiperonylamine: Decker et al., Ann. 395, 299, 321, 328 (1913); Rosenmund, Ber. Dtsch. Pharm. Ges. 29, 200 (1919). From safrole: Kindler, Peschke, Arch. Pharm. 270, 353 (1932). Structure study: Schneider, Müller, Ann. 615, 34 (1958).

Carzenide CAS Registry Number: 138-41-0 卡西尼特

CAS Name: 4-(Aminosulfonyl)benzoic acid
Additional Names: p-sulfamoylbenzoic acid; 4-carboxybenzenesulfonamide; p-sulfonamidobenzoic acid; benzoic acid 4-sulfamide
Percent Composition: C 41....
Literature References: Byproduct in the production of saccharin. Prepn from toluene p-sulfonamide: W. A. Noyes, Am. Chem. J. 7, 145 (1885); A. A. Goldberg, A. H. Wragg, J. Chem. Soc. 1960, 1408. Metabolism: L. M. Ball et al., Xenobiotica 8, 183 (1978). HPLC determn in saccharin samples: A. E. Mooser, J. Chromatogr. 287, 113 (1984). Toxicity data: D. Appenroth, H. Bräunlich, Pharmazie 38, 102 (1983).

Calcium Magnesium Acetate CAS Registry Number: 76123-46-1

CAS Name: Acetic acid, calcium magnesium salt
Additional Names: CMA
Trademarks: Ice-B-Gon (Chevron)
Literature References: C2H4O2.xCa.xMg. Prepn and use as deicer: S. A. Dunn, R. U. Schenk, Transport. Res. Rec. 776, 12 (1980); eidem, U.S. Federal Highway Administration Report FHWA-RD-79-109 (1980) pp 17. Prepn by fermentation: C. W. Marynowski et al., Ind. Eng. Chem. Prod. Res. Dev. 24, 457 (1985); via extraction and sorption: H. Reisinger, C. J. King, Ind. Eng. Chem. Res. 34, 845 (1995). Acute toxicity: G. A. Rausina et al., Acute Toxic. Data 1, 87 (1990). Environmental and toxicological evaluation: B. L. McFarland, K. T. O'Reilly, Chemical Deicers and the Environment, F. M. D'Itri, Ed. (Lewis Publishers, Chelsea, MI, 1992) pp 193-227. Anti-icing effect: E. E. Adams et al., ibid., pp. 481-493. Degradation in soil: D. W. Ostendorf et al., J. Environ. Qual. 22, 299 (1993). Effects on cement mortar: O. Peterson, Cem. Concr. Res. 25, 617 (1995). Book: Calcium Magnesium Acetate, D. L. Wise et al., Eds. (Elsevier Science Publishers, Amsterdam, 1991) pp 511.

BINOL CAS Registry Number: 602-09-5 1,1'-联-2-萘酚

CAS Name: [1,1'-Binaphthalene]-2,2'-diol
Additional Names: b-binaphthol; 2,2'-dihydroxy-1,1'-binaphthyl
Percent Composition: C 83.90%, H 4.93%, O 11.18%
Literature References: C2-symmetric ligand for metal-mediated stereoselective catalysis. Prepn: H. Walder, Ber. 15, 2166 (1882). Resolution of enantiomers: E. P. Kyba et al., J. Org. Chem. 42, 4173 (1977). Elucidation of catalyst structure: H. Sasai et al., J. Am. Chem. Soc. 115, 10372 (1993). Effect of substituents on enantioselectivity: C. Qian et al., J. Chem. Soc. Perkin Trans. 1 1998, 2097. Photochromism: M. Cavazza et al., J. Am. Chem. Soc. 118, 9990 (1996). Review of role in catalysis: R. Zimmer, J. Suhrbier, J. Prakt. Chem. 339, 758-762 (1997); with titanium: K. Mikami, Pure Appl. Chem. 68, 639-644 (1996); with rare-earth metals: H. Sasai et al., Chemtracts: Org. Chem. 11, 264-267 (1998); of synthesis and use as a chiral reagent and ligand: J. M. Brunel, Chem. Rev. 105, 857-897 (2005).

Ustilagic Acid CAS Registry Number: 8002-36-6

Additional Names: Ustizeain B
Literature References: C37H62-66O17; mol wt about 780. A mixture of partially acylated derivatives of a di-D-glucosyldihydroxyhexadecanoic acid. Antibiotic substance produced by the corn smut fungus Ustilago zeae: Haskins, Can. J. Res. 28C, 213 (1950); Lemieux et al., Can. J. Chem. 29, 409, 415 (1951); Reed, Holder, Can. J. Med. Sci. 31, 505 (1953); Haskins, US 2698843 (1955 to National Research Council, Canada). Biosynthesis: Boothroyd et al., Can. J. Biochem. Physiol. 33, 289 (1955). Production by submerged culture: Lemieux, CA 600121 (1960 to National Research Council, Canada).