其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Nogalamycin CAS Registry Number: 1404-15-5 诺拉霉素

CAS Name: [2R-(2a,3b,4a,5b,6a,11b,13a,14a)]-11-[(6-Deoxy-3-C-methyl-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-di...
Literature References: Antitumor antibiotic isolated from Streptomyces nogalater var. nogalater: B. K. Bhuyan, A. Dietz, Antimicrob. Agents Chemother. 1965, 836; B. K. Bhuyan et al., US 3183157 (1965 to Upjohn). Characterization: P. F. Wiley et al., Tetrahedron Lett. 1968, 663. Structure: eidem, J. Am. Chem. Soc. 99, 542 (1977). Stereochemistry: eidem, J. Org. Chem. 44, 4030 (1979). Biosynthesis: eidem, ibid. 43, 3457 (1978). Synthesis of L-nogalose, sugar component: L. Valente et al., Tetrahedron Lett. 1979, 1153; J. Yoshimura et al., Chem. Lett. 1979, 687. Partial stereospecific synthesis: R. P. Joyce et al., Tetrahedron Lett. 27, 4885 (1986). Molecular structure, absolute stereochemistry and interactions with DNA: S. K. Arora, J. Am. Chem. Soc. 105, 1328 (1983). Toxicity data: Z. Hadidian, PB Report 173334 (1966). Review of pharmacology: B. K. Bhuyan, C. G. Smith, Handb. Exp. Pharmacol. 38 (pt. 2), 623-632 (1975).

Hadacidin CAS Registry Number: 689-13-4 N-羟基-N-甲酰甘氨酸

CAS Name: N-Formyl-N-hydroxyglycine
Additional Names: N-formyl-N-hydroxyaminoacetic acid; N-hydroxyformamidoacetic acid
Percent Composition: C 30.26%, H 4.23%, N 11.76%, O 53.74%
Literature References: Antitumor antibiotic originally isolated from cultures of Penicillium frequentans Westling. Synthesis: Kaczka et al., Biochemistry 1, 340 (1962); Kinnel, Schoenewaldt, US 3154578 (1964 to Merck Co.). Biosynthesis: Stevens, Emery, Biochemistry 5, 74 (1966). Review: Shigeura, "Hadacidin" in Antibiotics I, D. Gottlieb, P. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 451-456.

Fredericamycin A CAS Registry Number: 80455-68-1 (S)-6'',7''-二氢-4,9,9''-三羟基-6-甲氧基-3''-[1(E),3(E)-戊二烯基]spiro[2H-苯[f]茚-2,8''-[8H]环戊鼉[g]异喹啉-1,1'',3,5,8(2H)-戊酮

CAS Name: (2S)-6',7'-Dihydro-4,9,9'-trihydroxy-6-methoxy-3'-[(1E,3E)-1,3-pentadienyl]spiro[2H-benz[f]indene-2,8'-[8H]cyclopent[g]isoquinoline]-1,1',3,5,8(2'H)-pentonePercent Composition: C 66.79%,...
Literature References: Antitumor antibiotic produced by Streptomyces griseus (FCRC-48); represents new structural class of antibiotics containing a spiro[4,4]nonane ring system. Isoln together with two biologically inactive components, fredericamycins B and C: R. C. Pandey et al., J. Antibiot. 34, 1389 (1981). Antimicrobial and cytotoxic activity in vitro and antitumor activity in vivo: D. J. Warnick-Pickle et al., ibid. 1402. Prepn and biological activity of water soluble salts: R. Misra, ibid. 51, 976 (1988). Structure determn by x-ray crystallography: R. Misra et al., J. Am. Chem. Soc. 104, 4478 (1982). Spectroscopic and mass spectral characterization: eidem, J. Antibiot. 40, 786 (1987). Synthetic studies: A. V. R. Rao et al., Chem. Commun. 1984, 1119; K. A. Parker et al., Tetrahedron Lett. 26, 2181 (1985). Synthesis of (±)-form: T. R. Kelly et al., J. Am. Chem. Soc. 108, 7100 (1986). Biosynthetic study: K. M. Byrne et al., Biochemistry 24, 478 (1985). Mechanism of action study: B. D. Hilton et al., ibid. 25, 5533 (1986).

Pactamycin CAS Registry Number: 23668-11-3 密旋霉素

CAS Name: 2-Hydroxy-6-methylbenzoic acid [(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methyl est...
Literature References: Antitumor antibiotic produced by Streptomyces pactum var pactum. Discovery and biological properties: Bhuyan et al., Antimicrob. Agents Chemother. 1961, 184. Isoln and characterization: Argoudelis et al., ibid. 191. Manuf: GB 980346 (1965 to Upjohn), C.A. 62, 11115f (1965). Structure: Wiley et al., J. Org. Chem. 35, 1420 (1970). Revised structure: D. J. Duchamp, Am. Crystallogr. Assn. (Winter Mtg., Albuquerque, 1972) p 23. Mechanism of action: T. A. Beerman et al., Adv. Enzyme Regul. 14, 207 (1976). 13C-NMR study: D. D. Weller et al., J. Antibiot. 30, 997 (1978). Biosynthesis: D. D. Weller, K. L. Rinehart, J. Am. Chem. Soc. 100, 6757 (1978). Review: Goldberg in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 498-515.

Anthramycin CAS Registry Number: 4803-27-4 安曲霉素

CAS Name: [11R-[2(E),11a,11ab]]-3-(5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-2-yl)-2-propenamide
Additional Names: 5,10,11,11a-tetrahydro-9,11-dih...
Literature References: Antitumor antibiotic produced by Streptomyces refuineus var thermotolerans, NRRL 3143: Leimgruber et al., J. Am. Chem. Soc. 87, 5791 (1965); Berger et al., US 3361742 (1968 to Hoffmann-La Roche). Also from Streptomyces spadicogriseus: N. Komatsu et al., J. Antibiot. 33, 54 (1980). Structure: Leimgruber et al., J. Am. Chem. Soc. 87, 5793 (1965). Synthesis: eidem, ibid. 90, 5641 (1968); Batcho, Leimgruber, US 3524849 (1970 to Hoffmann-La Roche). Activity studies: Horwitz, Grollman, Antimicrob. Agents Chemother. 1968, 21. Biosynthesis: L. H. Hurley et al., J. Am. Chem. Soc. 97, 4372 (1975). Review: Kohn in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 3-11.

Azaserine CAS Registry Number: 115-02-6 偶氮丝氨酸

CAS Name: L-Serine diazoacetate (ester)
Additional Names: O-diazoacetyl-L-serinePercent Composition: C 34.69%, H 4.08%, N 24.27%, O 36.97%
Literature References: Antitumor antibiotic produced by Streptomyces sp. Isoln, characterization, and antitumor activity: C. C. Stock et al., Nature 173, 71 (1954); J. Ehrlich et al., ibid. 72; Q. R. Bartz et al., ibid. 72; S. A. Fusari et al., J. Am. Chem. Soc. 76, 2878 (1954). Structural studies: idem et al., ibid. 2881. Synthetic studies: J. A. Moore et al., ibid., 2884; E. D. Nicolaides et al., ibid., 2887; T. J. Curphey, D. S. Daniel, J. Org. Chem. 43, 4666 (1978). Pathology and pharmacology studies: S. S. Sternberg, F. S. Philips, Cancer 10, 889 (1957). Crystal and molecular structure: A. Fitzgerald, L. H. Jensen, Acta Crystallogr. B34, 828 (1978). Review of carcinogenicity studies: IARC Monographs 10, 73-77 (1976). Review: Pettillo, Hunt, Antibiotics vol. 1, D. Gottlieb, P. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 481-493. Use in study of the progression of pancreatic adenocarcinoma in rat models: K. Nagy et al., Histochem. Cell Biol. 119, 405 (2003).

Carzinophilin A CAS Registry Number: 106486-76-4 连氮霉素B

CAS Name: 3-Methoxy-5-methyl-1-naphthalenecarboxylic acid (1S)-2-[[(1E)-1-[(3R, 4R,5S)-3-(acetyloxy)-4-hydroxy-1-azabicyclo[3.1.0]hex-2-ylidene]-2-[[(1Z)-1-(hydroxymethylene)-2-oxopropyl]amino]-2-...
Literature References: Antitumor antibiotic; alkylates DNA by interstrand crosslinking of the major groove. Isoln from Streptomyces sahachiroi: T. Hata et al., J. Antibiot. 7A, 107 (1954). Purification: H. Kamada et al., ibid. 8A, 187 (1955). Mechanism of action: J. W. Lown, K. C. Majumdar, Can. J. Biochem. 55, 630 (1977); T. Fujiwara, I. Saito, Tetrahedron Lett. 40, 315 (1999). Proposed structure: J. W. Lown, C. C. Hanstock, J. Am. Chem. Soc. 104, 3213 (1982). Identity with azinomycin B: E. J. Moran, R. W. Armstrong, Tetrahedron Lett. 32, 3807 (1991). Purification: K. Nagaoka et al., J. Antibiot. 39, 1527 (1986). Total structure as azinomycin B: K. Yokoi et al., Chem. Pharm. Bull. 34, 4554 (1986).

Noformicin CAS Registry Number: 155-38-4 5-氨基-N-(3-氨基-3-亚氨基丙基)-3,4-二氢-2H-吡咯-2-甲酰胺

CAS Name: 5-Amino-N-(3-amino-3-iminopropyl)-3,4-dihydro-2H-pyrrole-2-carboxamide
Additional Names: N-(2-amidinoethyl)-5-imino-2-pyrrolidinecarboxamide; 2-[N-(2-amidinoethyl)carbamoyl]-5-iminopy...
Literature References: Antiviral agent produced by Nocardia formica, culture no. N.R.R.L. 2470: Peck et al., US 2804463 (1957 to Merck Co.); Gray, Phytopathology 45, 281 (1955). Activity studies: Furusawa et al., Proc. Soc. Exp. Biol. Med. 116, 938 (1964); eidem, Med. Pharmacol. Exp. 12, 259 (1965). Synthesis of (+)- and (±)-forms: Diana, J. Med. Chem. 16, 857 (1973).

Abikoviromycin CAS Registry Number: 31774-33-1 阿孙病毒素

CAS Name: 7-Ethylidene-1a,2,3,7-tetrahydrocyclopent[b]oxireno[c]pyridine
Additional Names: 4,4a-epoxy-5-ethylidene-2,3,4,4a-tetrahydro-5H-1-pyridine; abicoviromycin; latumcidin
Percent Compo...
Literature References: Antiviral antibiotic produced by Streptomyces abikoensis and Streptomyces rubescens. Chromatographic isoln from broth cultures: Umezawa et al., Jpn. Med. J. 4, 331 (1951); C.A. 46, 7167 (1952); Umezawa, JP 54 6200 (1954 to Nippon). Identity with latumcidin: Sakagami et al., J. Antibiot. 11A, 231 (1958). Structure: Gurevich et al., Tetrahedron Lett. 1968, 2209. Stereochemistry: Kono et al., J. Antibiot. 23, 572 (1970); Gurevich et al., Khim. Prir. Soedin. 7, 104 (1971), C.A. 75, 5752e (1971). Crystal and molecular structure of the selenate: Y. Kono et al., Acta Crystallogr. B27, 2341 (1971). In vitro antiviral activity: V. M. Roikhel, N. A. Zeitlenok, Antibiotiki 14, 969 (1969), C.A. 72, 19394q (1969).